• share
• favorite_border

Researchers at IRB Barcelona report mutation rate variation across the human genome. Regions with low mutation rates correlate with hypomethylation (low methylation levels), a way cells control which genes are turned on or off. Published in Nucleic Acids Research, the study sheds light on the accumulation of somatic mutations through cancer and ageing, providing valuable knowledge.

• share
• favorite_border

Researchers from IRB Barcelona describe a mechanism by which senescent cells generated by chemotherapy survive inside tumours.

• share
• favorite_border

The research, which was conducted on mice, demonstrates how these tiny nanomachines are propelled by urea present in urine and precisely target the tumour, attacking it with a radioisotope carried on their surface.

• share
• favorite_border

Identification of genes under recent selection provides insights into the molecular mechanisms of human-related adaptation in Candida pathogens.

• share
• favorite_border

Researchers at IRB Barcelona discover unexpected patterns in mutation risks across individuals, uncovering 13 distinct genomic patterns.

• share
• favorite_border

• Researchers at IRB Barcelona reveal the pivotal role of iron accumulation in the development of fibrotic diseases and propose that iron detection via MRI can serve to diagnose fibrosis. • Fibrotic diseases account for 45% of all mortality in developed countries. • Published in Nature Metabolism, the study points to new therapeutic opportunities that target iron.

• share
• favorite_border

Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.

• share
• favorite_border

A team of researchers describes in Nature Cell Biology the mechanism by which the MEC-2 protein condensates of the touch receptor neurons transition from fluid to solid-like states, switching their role in the transmission of mechanical forces. These findings pave the way for developing innovative therapies and treatments.

• share
• favorite_border

Spain is the first country in the world to have this technology • Results showing the clinical utility of the test were published in Lancet Oncology and the Journal of National Cancer Institute • The test is now available to oncologists and pathologists and will benefit an estimated 24,000 patients each year in Spain

• share
• favorite_border

Chromosomal instability is a phenomenon characterised by rapid changes in the number and structure of chromosomes during cell division. It is very common in solid tumours and it is linked to the aggressive spread of cancer, that is to say, metastasis.

• share
• favorite_border

A collaborative study undertaken by the Navarrabiomed Biomedical Research Center (Pamplona, Navarre), the Institute of Neurosciences CSIC-UMH (Sant Joan d’Alacant, Valencian Community) and IRB Barcelona (Barcelona, Catalonia) shows that the administration of ranolazine, a drug currently used to treat heart conditions, improves the efficacy of current therapies for melanoma, in mouse models of this disease.