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A team of neuroscientists has uncovered a neural network that can restore diaphragm function after spinal cord injury. The network allows the diaphragm to contract without input from the brain, which could help paralyzed spinal cord injury patients breathe without a respirator.
Investigators at Case Western Reserve University School of Medicine and University Hospitals Health System have identified a new molecular pathway that controls lifespan and healthspan in worms and mammals. In a Nature Communications study published today, researchers showed that worms with excess levels of certain proteins lived longer and healthier than normal worms. In addition, mice with excess levels of these proteins demonstrated a delay in blood vessel dysfunction associated with aging. The study has major implications for our understanding of aging and age-associated disorders.
The Case Center for Synchrotron Biosciences has been awarded second prize in the 2017 Sharing Research Resources Award by the American Association of Medical Colleges. According to the AAMC, “award winners demonstrate successful sharing of research resources between institutions and campuses, including medical schools, teaching hospitals, and other academic institutions.”
Streamlining investigations and prosecutions of opiate dealers is goal of three-year U.S. Department of Justice-funded research
Scientists have determined that fungus may play a key role in chronic intestinal inflammation disorders. They found that patients with Crohn’s disease tend to have much higher levels of the fungus Candida tropicalis compared to their healthy family members. A new review published in Digestive and Liver Disease looks at these findings and provides insights into potential new therapeutic approaches using antifungals and probiotics in the treatment of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD).
With a DOE grant, two professors will create a new investment tool to manage risk and catalyze funding at critical stages for energy companies
A Case Western Reserve University researcher has turned the origami she enjoyed as a child into a patent-pending soft robot that may one day be used on an assembly line, in surgery or even outer space.
Like its Egyptian namesake, The Walmart Book of the Dead contains spells and illustrations (albeit as descriptive passages), using them to craft a loose narrative in short chapters centered around a different character; there's a shoplifter, circuit court judge, hustler and, of course, a greeter.
A new magnetic resonance imaging (MRI) contrast agent being tested by researchers at Case Western Reserve University not only pinpoints breast cancers at early stages but differentiates between aggressive and slow-growing types.
With a new $5.5 million, five-year federal grant, a Case Western Reserve University researcher is leading an international team to develop functional materials inspired by some of the most desirable substances found in nature. The bioinspired materials produced in the project will be tested in soft-sided robots, but are expected to have a wide range of practical uses.
With geographic barriers limiting treatment options for many people with multiple sclerosis (MS) , a Case Western Reserve University researcher will use a new $4.9 million award to test online- and teleconference-based adaptations of methods that reduce fatigue and improve quality of life when delivered in person.
Kurt Lu, MD, assistant professor of dermatology at Case Western Reserve University School of Medicine, has received a five year, $3.9 million grant from the National Institutes of Health to expand countermeasures against chemical threats, including mustard gas and mustard-related compounds. The molecular action of mustard on DNA leads to strand breaks and eventual cell death. The goal of the grant is to augment the body’s immune system after exposure, reducing skin swelling and pain as well as enhancing tissue repair.
With $1.8 million in new funding, Case Western Reserve Professor Mark Joseph, and his colleagues are leading an effort to learn how mixed-income development might more effectively promote social equity and inclusion—as initially intended.
Martha Sajatovic, MD, Professor of Psychiatry and of Neurology at Case Western Reserve University School of Medicine, Willard Brown Chair in Neurological Outcomes Research and Director of the Neurological and Behavioral Outcomes Research Center at University Hospitals Cleveland Medical Center, is the recent recipient of two major research grants.
Biomedical engineering researchers at Case Western Reserve University are refining more than 15 years of work on an electrical nerve-block implant, focusing their next step on new applications related to treating asthma and heart failure.
After Hurricane Katrina devastated New Orleans a dozen years ago, there was a sharp and immediate drop in personal debt among residents living in city’s most flooded blocks, according to a new analysis.
Nicole Steinmetz, PhD, Associate Professor of Biomedical Engineering, Radiology, member of the Case Comprehensive Cancer Center and the Center for RNA Science and Therapeutics in the Division of General Medical Sciences at Case Western Reserve University School of Medicine and the holder of the George J. Picha Designated Professor in Biomaterials, has received a major grant from the National Institutes of Health to help understand how a virus-like particle from plants stimulates potent anti-tumor responses. Under the grant, Steinmetz and colleagues will further test a tiny nanoparticle-based therapeutic that her team developed which targets the body’s own cancer immunity cycle.
Scientists have found distinctive portions of genetic material—known as lncRNAs—that help sperm develop. Male mice lacking a particular lncRNA have low sperm count, suggesting lncRNAs could represent novel infertility drug targets.
The first new national guidelines since 2004 on identifying and treating high blood pressure in children and adolescents (aged 3-18 years old) have been published by the American Academy of Pediatrics (AAP), which convened a panel of experts to produce the new recommendations. The AAP report, Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents, offers a series of evidence-based recommendations for pediatricians derived from a comprehensive review of nearly 15,000 medical studies published since 2004.
The notion that young females limit their own progress based on what they believe about their intelligence—called the “bright girl effect”—does not persist into adulthood, according to new research from Case Western Reserve University.
Researchers at Case Western Reserve University School of Medicine have developed a method that could make magnetic resonance imaging—MRI—multicolor. Current MRI techniques rely on a single contrast agent injected into a patient’s veins to vivify images. The new method uses two at once, which could allow doctors to map multiple characteristics of a patient’s internal organs in a single MRI. The strategy could serve as a research tool and even aid disease diagnosis.
Rodeo Therapeutics, a new drug development company created by two highly regarded Case Western Reserve University School of Medicine researchers, has raised $5.9 million to develop small-molecule drugs that promote the body’s repair of diseased or damaged tissues.
The International Society for Magnetic Resonance in Medicine (ISMRM) has provided new guidance in the use of contrast agents during MRI scans. Emerging research suggests gadolinium-based contrast agents, injected in a patient’s veins to brighten tissues in MRI images, accumulate in the brain. More than 300 million doses of such drugs have been administered since their introduction in 1987.
Cytokines might be the key to repairing diabetic nerve damage. Diabetes devastates nerve cells, which can lead to poor circulation, muscle weakness, blindness, and other side effects. The study showed diabetic mice can’t repair nerve cells after damage due to low levels of specific cytokines.
Even among people who had just joined a gym and expected to visit regularly, getting paid to exercise did little to make their commitment stick, according to a new study from Case Western Reserve University.
Alex Huang has been awarded a $150,000 St. Baldrick’s Foundation Innovation Award.
Scientists have found a single protein—Ptbp2—controls a network of over 200 genes central to how developing sperm move and communicate. The protein works by regulating how RNA is processed during each stage of sperm development.
High doses of vitamin D taken one hour after sunburn significantly reduce skin redness, swelling, and inflammation, according to double-blinded, placebo-controlled clinical trial out of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center.
Researchers from Case Western Reserve University School of Medicine and The Cleveland Clinic designed a way to screen brain tumor cells and identify potential drug targets missed by other methods.
Nicole F. Steinmetz, PhD, director of the Center for Bio-Nanotechnology at Case Western Reserve School of Medicine, has received two major grants from the National Institutes of Health to develop microscopic drug-delivery systems for patients living with breast cancer, and patients at risk for serious blood clots.
The researchers discovered injecting potato virus particles into melanoma tumor sites activates an anti-tumor immune system response. And simultaneously injecting the nanoscale plant virus particles and a chemotherapy drug—doxorubicin—into tumor sites further helps halt tumor progression in mice.
Researchers at Case Western Reserve University School of Medicine have shown a high fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation.
A microscopic fungus called Candida tropicalis triggered gut inflammation and exacerbated symptoms of Crohn’s disease, in a recent study conducted at Case Western Reserve University School of Medicine.
Results from four recent randomized clinical trials suggest that using medications that offer glucose control while reducing the risk for cardiovascular disease could improve patient outcomes.
The majority of college-aged male aggressors of physical, sexual and emotional violence also reported being victims of violence themselves, both in childhood and as young adults
The National Cancer Institute recently awarded a $6 million grant to the Case Comprehensive Cancer Center and Case Western Reserve University School of Medicine to continue research on Barrett’s Esophagus, a potentially fatal condition caused by long-term acid reflux.
It may be possible to disrupt harmful blood clots in people at risk for heart attack or stroke without increasing their risk of bleeding, according to a new study published in Nature Communications.
A diagnostic MRI followed by one of three MRI-guided biopsy strategies is a cost-effective method to detect prostate cancer, according to a new study out of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center.
Lung cancer tumors were prevented in mice by a novel small molecule that directly activates a tumor suppressor protein.
In a new study, a team of researchers from Case Western Reserve University and Gebze Technical University (GTU) in Turkey used data science to determine and predict the effects of exposure to weather and other conditions on materials in solar panels.
A research volunteer with multiple sclerosis and another who had suffered stroke walked significantly better and faster with the aid of neural stimulation systems, potentially laying the foundation for implanted systems that restore some independence to people in these populations.
Mothers smoking crack cocaine during pregnancy—and its lingering effects on their children—are the focus of 20-plus years of ongoing research by Case Western Reserve University
17 business innovations to be honored for contributions to the 17 U.N. Sustainable Development Goals.
An early-stage researcher at Case Western Reserve University School of Medicine is receiving a major grant to help address the problem in an innovative way.
Researchers discovered three novel genetic mutations associated with Fuchs endothelial corneal dystrophy, the most common corneal disorder requiring transplantation.
More than a third of HIV patients develop oral conditions from immune systems compromised by the virus and its treatment, according to the National Institutes of Health (NIH)
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