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Jefferson researchers used gene signatures and energy metabolism to predict clinical outcome, rather than gene mutations.

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Intense-modulated radiotherapy proves advantageous: a higher dose and less toxicity could lead to better outcomes.

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The latest advances in both breast cancer treatment and research – including innovations in diagnostic, surgical, chemotherapy and radiation approaches – will be discussed Friday, April 8, 2011, at a breast cancer symposium at the Kimmel Cancer Center at Jefferson in Philadelphia.

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Giving girls with Turner syndrome low doses of estrogen, as well as growth hormone, years before the onset of puberty, increases their height and offers a wealth of other benefits, say a team of researchers led by Thomas Jefferson University. Their report is published in the March 31st issue of The New England Journal of Medicine (NEJM).

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Volumetric Modulated Arc Therapy (VMAT) technology is based on the most accurate dose calculation algorithm that dramatically shortens treatment delivery time. “With the combination of VMAT and Monte Carlo, our patients receive fast daily treatments that maximize dose to cancer and minimize exposure to surrounding healthy tissues,” said Adam Dicker, MD, PhD.

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Thomas Jefferson University is part of a pivotal, nationwide clinical trial to evaluate rosuvastatin as a treatment to reduce the risk of colon cancer.

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It has been thought that the quality of the physician-patient relationship is integral to positive outcomes but until now, data to confirm such beliefs has been hard to find. Through a landmark study, a research team from Jefferson Medical College (JMC) of Thomas Jefferson University has been able to quantify a relationship between physicians’ empathy and their patients’ positive clinical outcomes, suggesting that a physician’s empathy is an important factor associated with clinical competence. The study is available in the March 2011 issue of Academic Medicine.

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Reporting in Nature, scientists from Thomas Jefferson University have determined that a single protein called FADD controls multiple cell death pathways, a discovery that could lead to better, more targeted autoimmune disease and cancer drugs.

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Recently, a research team from the Department of Emergency Medicine at Jefferson Medical College of Thomas Jefferson University discovered an alarming amount of lead contamination in ceramic cooking and eating utensils sold in Philadelphia’s Chinatown.

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Thomas Jefferson University welcomes two new, seasoned clinicians and researchers to its Department of Radiation Oncology: Nicole Simone, M.D., from the National Institutes of Health’s National Cancer Institute and Bo Lu, M.D., Ph.D, from Vanderbilt University.

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Cataldo Doria, M.D., Ph.D., Nicoletti Family Professor of Transplant Surgery at Jefferson Medical College of Thomas Jefferson University; director of the Division of Transplantation; and co-director of the liver tumor program at Thomas Jefferson University Hospital is the first surgeon at Jefferson to perform a robotically-assisted liver resection.

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Researchers from Jefferson’s Kimmel Cancer Center have genetic evidence suggesting the antioxidant drugs currently used to treat lung disease, malaria and even the common cold can also help prevent and treat cancers because they fight against mitochondrial oxidative stress—a culprit in driving tumor growth.

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A molecular analysis of lymph nodes in patients deemed colorectal cancer-free was found to be an effective predictor of recurrence.

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Hospital takes creative spin on getting more employees to wash hands.

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Real-time, 4D approach demonstrated at Thomas Jefferson University predicts tumor motion during treatment.

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Anthony J. DiMarino, M.D., William Rorer Professor of Medicine; and Chief of the Division of Gastroenterology and Hepatology in the Department of Medicine at Thomas Jefferson University Hospital, announces the appointment of Daniel M. Quirk, M.D., M.P.H., as an associate professor.

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For first time, animal study suggests that Sirt1 gene inhibits prostatic intraepithelial neoplasia.

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Animal study suggests the control of cholesterol may be useful in the reduction of breast cancer development and aggressiveness

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It took 12 years and a creation of a highly sophisticated transgenic mouse, but researchers at Kimmel Cancer Center at Jefferson have finally proven a long suspected theory: Inflammation in the breast is key to the development and progression of breast cancer.

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Study in mice suggests maintaining a healthy diet is “prudent” for men.

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Underwood-Memorial Hospital of Woodbury, New Jersey has joined the Jefferson Neuroscience Network (JNN) as one of the first New Jersey participants. Through this collaboration, Jefferson and Underwood will provide some of the most sophisticated care and expertise available to patients with time-sensitive neurovascular diseases.

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A recent listing* of Philadelphia adult kidney transplant programs by The Scientific Registry of Transplant Recipients (SRTR) has listed the transplant program at Thomas Jefferson University Hospital as having the shortest wait times for patients seeking a transplant among programs that have a three-year survival rate of greater than 90 percent.

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A research team from the National Cancer Institute (NCI) designated Kimmel Cancer Center (KCC) at Jefferson has concluded – for the first time – that a multidisciplinary clinic approach to aggressive prostate cancer can improve survival in patients. The results from the 15-year study of the multidisciplinary clinic can be found in the November issue of Journal of Oncology Practice.

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Researchers in the Departments of Psychiatry and Neurology at Jefferson Medical College of Thomas Jefferson University were recently awarded a $2.6 million grant from The National Institute of Health to study whether increasing participation in cognitive, physical and/or social activities prevents cognitive decline in older African Americans with Mild Cognitive Impairment (MCI).

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Thomas Jefferson University researchers have been awarded a W.W. Smith Charitable Trust medical research grant. This one-year grant awards $100,000 to their group to help support their innovative cancer research, and one of the questions they will address is why African-Americans respond poorly to common chemotherapeutic agents used to treat pancreatic cancer.

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The Department of Otolaryngology – Head and Neck Surgery at Thomas Jefferson University Hospital (TJUH) and Jefferson Medical College of Thomas Jefferson University recently welcomed three new physicians to its ranks.

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Edith P. Mitchell, M.D., clinical professor, Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University, and associate director of Diversity Programs for the Kimmel Cancer Center at Jefferson, was recently named ‘Physician of the Year’ by CancerCare, a national nonprofit organization that provides free, professional support services to anyone affected by cancer: people with cancer, caregivers, children, loved ones, and the bereaved.

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For his work in defining how a type of head and neck cancer should be studied in clinical trials and ultimately be treated, Robert Den, M.D., a radiation oncologist at the Kimmel Cancer Center at Jefferson, has been selected as the clinical winner of the Poster Discussion Recognition Award at the American Society of Radiation Oncology (ASTRO) annual meeting in San Diego.

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During “chart rounds” radiation oncologists in the U.S. and Canada spend limited time reviewing patient cases for potential errors, say researchers at the Kimmel Cancer Center at Jefferson. At the ASTRO annual meeting, Jefferson researchers reveal how variable and potentially haphazard the process is.

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Kimmel Cancer Center at Jefferson radiation oncology researchers say patients have a right to know the true picture of risks and benefits in these trials

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Demetrius H. Bagley, M.D., the Nathan Lewis Hatfield Professor of Urology in the Department of Urology at Jefferson Medical College (JMC) of Thomas Jefferson University was recently honored as the 2010 recipient of the Karl Storz Lifetime Achievement Award in Endourology at the World Congress of Endourology.

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The disorder primarily affects patients with renal insufficiency who are exposed to gadolinium-based magnetic resonance imaging contrast agents

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A research team from the Jefferson Sleep Disorders Center at Thomas Jefferson University Hospital has utilized a simple, eight-item pre-operative questionnaire about obstructive sleep apnea syndrome that could help identify patients at risk for complications following surgery, according to a report in the October issue of Archives of Otolaryngology–Head & Neck Surgery, one of the JAMA/Archives journals.

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In the October 17 issue of Nature Methods, researchers at Thomas Jefferson University describe how they can transfer genes into brain neurons intravenously, using a viral gene delivery vehicle (vector) that causes no side effects.

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Researchers say the robot – the first worldwide to be tested in patients - is designed to be consistently accurate in placement of radioactive seeds during prostate brachytherapy.

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The odds of developing some type of cancer increase with age; sixty percent of cancer in the United States occurs in persons aged 65 and older. At the same time, senior patients may have acute or chronic diseases that make treating their cancer challenging. That’s why the Kimmel Cancer Center at Jefferson has established a new, multidisciplinary Senior Adult Oncology Center to provide a comprehensive consultation for senior patients in order to meet those special challenges.

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A team of researchers at Thomas Jefferson University has tested a semi-synthetic opioid they say has the potential to improve the treatment of these newborns, which could save hundreds of millions in healthcare costs annually if future tests continue to show benefit.

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The Department of Surgery at Thomas Jefferson University Hospital (TJUH) and Jefferson Medical College of Thomas Jefferson University recently welcomed five new surgeons to its ranks.

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According to a study from Thomas Jefferson University, the use of computer-aided detection (CAD) is increasing, in both screening and diagnostic mammography. The findings will be published in the October issue of the Journal of the American College of Radiology.

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The Division of Transplantation in the Department of Surgery at Thomas Jefferson University Hospital (TJUH) has started a live donor liver transplant program. Live donor liver transplantation (LDLT) is a procedure in which a living person donates a portion of his or her liver to another person.

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Doylestown Hospital is joining the Jefferson Neuroscience Network (JNN). Through this collaboration, Jefferson and Doylestown Hospital will provide the most sophisticated care and expertise available to patients with time-sensitive neurovascular diseases.

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Leonard Gomella, M.D., F.A.C.S., the Bernard W. Godwin, Jr. Professor of Prostate Cancer, associate director for Clinical Affairs at the Kimmel Cancer Center (KCC) at Jefferson, and Chair of the Department of Urology at Jefferson Medical College of Thomas Jefferson University, has been appointed to the editorial council at Urology Times. He will represent the area of urologic cancer on the editorial council.

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A molecule known to be involved in progressive heart failure has now been shown to also lead to permanent damage after a heart attack, according to researchers at Thomas Jefferson University.

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An abrupt, fatal heart attack in a young athlete on the playing field is a tragedy destined to repeat itself over and over until more is understood about hypertrophic cardiomyopathy (HCM), a genetic disorder that is the most common cause of sudden death in young people but which affects people of all ages.

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Jefferson Hospital for Neuroscience (JHN) is launching the Jefferson Neuroscience Network (JNN) to promote collaboration among area hospitals to advance neuroscience care throughout the region. Chestnut Hill Hospital is the first hospital to join JNN.

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Four key studies now propose a new theory about how cancer cells grow and survive, allowing researchers to design better diagnostics and therapies to target high-risk cancer patients. These studies were conducted by a large team of researchers at Thomas Jefferson University’s Kimmel Cancer Center.

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Scientists at Jefferson Medical College have received a four-year, $3 million National Institutes of Health grant funded by the National Heart, Lung and Blood Institute to study variations of platelet function, specifically, the genetics of platelet gene expression. The study aims to find data that can be translated into novel therapeutic strategies and develop better predictors of cardiovascular disease.

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Robert H. Rosenwasser, M.D., F.A.C.S., F.A.H.A., professor and chair, Department of Neurological Surgery at Jefferson Medical College of Thomas Jefferson University; and co-director of the Stroke Program at Thomas Jefferson University Hospital has been named to the first endowed chair in the department’s history. This endowment honors the former chair, Jewell L. Osterholm, M.D., who led the department for two decades.

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Pancreas surgery specialist Charles J. Yeo, M.D., Samuel D. Gross Professor and Chair, Department of Surgery at Jefferson Medical College of Thomas Jefferson University, and Co-Director of the Pancreatic, Biliary Tract and Related Cancer Center at Thomas Jefferson University Hospital, recently performed his 1,000th Whipple procedure (pancreaticoduodenectomy).

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Reporting in the journal Urology, researchers at Thomas Jefferson University have found that a pre-emptive multimodal pain regimen that included pregabalin (Lyrica) decreased the use of opioid analgesics in patients undergoing robotic-assisted laparoscopic radical prostatectomy.