New Columbia research suggests a genomic test may provide detailed information on how well a transplanted heart is performing. The gene expression profiling test is currently used to detect the absence of heart transplant rejection instead of routine invasive heart muscle biopsies, but has now been shown to have greater promise in measuring heart function.
A new study from Columbia University Medical Center shows that among men treated for breast cancer, African-American men are more likely to die of the disease compared with white men. The results of the study are being published online March 16 in the Journal of Clinical Oncology (JCO).
Research has shown that people who exercise do better on memory tests. Now a new Columbia study explains specifically what exercise does within the brain. Exercise, the researchers found, targets a region of the brain within the hippocampus, known as the dentate gyrus, which underlies normal age-related memory decline that begins around age 30 for most adults.
Aerobic exercise is widely recognized to reduce the risk of coronary heart disease, but until now, researchers have not fully understood the biological mechanisms behind the effect of exercise on cardiovascular health. Findings of a new Columbia study show how exercise decreases inflammation, which reduces the risk of atherosclerosis "“ fatty build-ups in the arteries "“ that cause most cases of heart disease.
A prostate cancer clinician who helped discover a gene responsible for up to 70% of prostate cancer cases, and a scientist credited with improving the predictive diagnostic and prognostic accuracy of prostate and bladder cancers, have joined the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital.
Researchers at Columbia University Medical Center have uncovered the complex structure of a protein that serves as a central energy gauge for cells, providing crucial details about the molecule necessary for developing useful new therapies for diabetes and possibly obesity. A paper published online today in the journal Science details this structure, helping to explain one of the cell's most basic and critical processes.
Women with breast cancer who receive compounds that stimulate white blood cell production to help their bodies better tolerate chemotherapy are at an increased risk of developing a type of leukemia or a condition called myelodysplastic syndrome, according to a new study in the February 7 Journal of the National Cancer Institute.
An international team of researchers, led by Columbia University Medical Center, Boston University School of Medicine and the University of Toronto, has uncovered a major new gene "“ SORL1 "“ implicated in late-onset Alzheimer's disease. Replicated in four distinct ethnic groups, SORL1 is only the second genetic variant for late-onset Alzheimer's.
CRF brings experts to New York City from around the world for the Third Annual International Conference on Cell Therapy for Cardiovascular Diseases, January 17 "“ 19. Dedicated to new advances in this emerging field, the three-day session will feature an in-depth view of cell-based therapies for myocardial repair and regeneration, and cutting-edge research findings.
A simple blood test that analyzes a heart transplant patient's genes has been evaluated by leading transplant centers and shows that it can accurately detect the absence of heart transplant rejection, according to data reported in an invited editorial authored by a consensus team of international heart transplant experts, including a physician-scientist at NewYork-Presbyterian Hospital and Columbia University Medical Center.
Columbia University announces today that it recently executed an exclusive license agreement for a next generation DNA sequencing technology to Intelligent Bio-Systems (IBS), Inc. This innovative DNA-sequencing technology was invented by Dr. Jingyue Ju, professor of Chemical Engineering and head of DNA Sequencing and Chemical Biology at the Judith P. Sulzberger, M.D. Columbia Genome Center at Columbia University.
The Cardiovascular Research Foundation (CRF) brings experts to New York City from around the world for the Third Annual International Conference on Cell Therapy for Cardiovascular Diseases. Dedicated to new advances in this emerging field, the three-day session will feature an in-depth view of cell-based therapies for myocardial repair and regeneration, and cutting-edge research findings.
A study published in the New England Journal of Medicine led by Columbia University Medical Center and NewYork-Presbyterian Hospital researchers showed that an anti-clotting agent called bivalirudin, when used by itself to treat acute coronary syndromes, reduced the risk of major bleeding, a key risk for mortality, by 47 percent compared with the standard combination drugs.
Columbia University Medical Center researchers are investigating whether these most common symptoms of attention deficit hyperactivity disorders (ADHD) could be causing people to smoke. If that is the case, will treatment for ADHD combined with the standard treatment to help people quit smoking "“ the patch with counseling "“ increase the quit rates for smokers trying to quit?
CUMC research at AHA this year includes presentations on the molecular roots of atrial fibrillation, genetic influence on heart transplant rejection, the cost of end-stage heart failure, and repairing heart failure damage with stem cells.
Having diabetes should not automatically disqualify you from being considered for a heart transplant, according to a study published in Circulation: Journal of the American Heart Association.
Genetic research over the past decade has linked Ashkenazi Jewish ethnicity to an increased risk for hereditary breast cancer, so much so that certain gene mutations have become known as "Jewish ancestral mutations." But a new study released in the November 2006 issue of The American Journal of Public Health challenges this population-based approach, warning that disparities in access to care and other unintended consequences for specific ethic groups can result, and may have already occurred.
People who have just suffered their first ischemic stroke, a blood clot in the brain, often have elevated inflammatory biomarkers in their blood that indicate their likelihood of having another stroke or an increased risk of dying, according to Columbia University Medical Center researchers at NewYork-Presbyterian Hospital.
Columbia University Medical Center & New York State Psychiatric Institute faculty, Jeffrey Lieberman, M.D., chair of psychiatry; David Shaffer, M.D., chief of the child and adolescent psychiatry division; &, Lorna Role, Ph.D., professor of anatomy and cell biology, have been honored by NARSAD for significant contributions to psychiatric research.
Columbia University will award the 2006 Louisa Gross Horwitz Prize to structural biologist Roger D. Kornberg, Ph.D., of Stanford. He will be honored for his work revolutionizing our understanding of gene transcription, the first step in transforming the genomic code in the cell into proteins, which run the cell. It was also announced today that Dr. Kornberg has won the 2006 Nobel Prize in Chemistry.
The NIH announced today that Columbia University Medical Center is a recipient of its new Clinical and Translational Science Award (CTSA), an initiative that will transform how clinical and translational research is conducted nationally. The CTSA centers will form a national consortium focused on innovation, streamlining and expediting clinical research and the delivery of new treatments to patients.
Sixteen-year-olds who weighed less than 2,000 grams (about 4.5 pounds) at birth and are not disabled are still more likely than the average teenager to have physical and mental difficulties, according to a report in the October issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
Cardiologists know treating depression likely will benefit patients complaining of cardiovascular problems, but lack the guidance to properly diagnose or recommend treatment for depression, according to a report out today from an NHLBI Working Group.
Columbia University Medical Center researchers have identified an emotional control circuit in the human brain which keeps emotionally intense stimuli from interfering with mental functioning. These results significantly enhance our understanding of the neurobiology underlying psychiatric disorders involving emotional control, such as post traumatic stress disorder (PTSD) or depression.
CUMC researchers have successfully restored normal memory and synaptic function in mice suffering from Alzheimer's disease. They identified an enzyme that is required for normal cognition but that is impaired in a mouse model of Alzheimer's. Mice regained the ability to form new memories when the enzyme's function was elevated.
Researchers from Columbia University Medical Center have discovered a protein in nerve cells that acts as a switch for chronic pain, and have applied for a patent to develop a new class of drugs that will block chronic pain by turning this switch off. The discovery is published on the website of Neuroscience, and will appear in the publication's Aug. issue.
Cancer researchers at Columbia University Medical Center have found that a protein known for driving the growth of cancer also plays a surprising role in restoring the ability of neurons to regenerate, making it an important target for addressing spinal cord damage or neurological diseases like Alzheimer's.
"Diabetes is the only major disease with a death rate that continues to be on the upswing," proclaimed a front-page New York Times story this week. Now, for the first time, researchers at Columbia University Medical Center have identified a reliable, non-invasive imaging method that may eventually enable more precise care of people with diabetes by measuring their quantity of insulin-producing pancreatic beta cells.
A study by a Columbia University Medical Center researcher shows that 99 percent of participants experienced either a return to menstruation or became pregnant within 90 days after stopping an investigational, low-dose oral contraceptive taken every day without placebo. Findings from the first large clinical examination were presented this week at the American College of Obstetricians and Gynecologists Annual Clinical Meeting.
New research from Columbia University Medical Center has found that as many as 30 percent of patients with stage III colon cancer who were prescribed six months of chemotherapy stopped their treatment prematurely. Stopping chemotherapy for colon cancer prematurely was shown to be equivalent to receiving no treatment at all.
A new study from Columbia University Medical Center researchers at NewYork-Presbyterian Hospital/Columbia, who are members of the Southwest Oncology Group (SWOG), suggests that certain changes in prostate-specific antigen (PSA) levels may serve as surrogate endpoints for prostate cancer survival.
If you're middle age and sleep five or less hours a night, you may be increasing your risk of developing high blood pressure, according to a study released by Columbia University's Mailman School of Public Health and the College of Physicians and Surgeons.
After the rise in safety concerns surrounding Cox-2 inhibitors, people suffering from chronic shoulder pain had just two therapy options - take Advil, or have surgery. But a new study shows that sodium hyaluronate is effective for shoulder pain.
Results from the largest-ever multi-center U.S. registry on the efficacy of carotid stenting shows that the procedure is safe in patients who are at high risk for standard surgical therapy. The registry, an FDA-required post-approval study, known as CAPTURE will be presented March 14 at the ACC Scientific Sessions.
A multi-center clinical study is the first to show that drug-eluting stents outperform the current "gold standard" radiation treatment in managing coronary restenosis and in preventing further clogging of coronary arteries.
A new study pinpoints the role that two genes "“ Factor H and Factor B "“ play in the development of nearly three out of four cases of age-related macular degeneration (AMD), a devastating eye disease that affects more than 10 million people in the United States.
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