Researchers have identified a key mechanism linking the master molecular clock in the brain to changes in the external firing activity of those circadian clock neurons. It involves the GSK3 kinase enzyme, which is also the target of mood-stabilizing drugs used to treat bipolar disorder.
Antibody VRC01 proves safe for individuals infected with HIV-1 but only modestly controls the virus in participants who stop receiving antiretroviral therapy.
UAB launches study to see if family caregivers for dementia patients can benefit and improve quality of life from learning strategies to alter care-resistant behavior, such as refusal to take a bath, take medicine, accept routine mouth care, abstain from alcohol or go to a medical appointment.
UAB researchers hope to establish Cialis as a therapeutic agent for pregnant women exposed to chlorine and bromine during industrial accidents or acts of terrorism.
Asthma caused by adult exposure to cockroach detritus is blocked in mice that were vaccinated as newborns with a particular bacteria, Enterobacter that expresses alpha-1,3-glucan molecules on its surface.
UAB doctors say stroke prevention treatments are not one-size-fits-all, and treatment options can be individualized using this hierarchical ranking.
According to the CDC, sports-related dental injuries account for more than 600,000 emergency room visits each year.
The contentious presidential campaign is causing stress among friends who hold different opinions on the candidates. UAB's Josh Klapow sheds light on how to cope if your friend is voting for the other side.
An Alabama woman asked her primary care physician one question that may have saved her life — is it time for me to have a mammogram?
Those living in more advantaged neighborhoods are less likely to have a stroke than are their counterparts who live in less advantaged neighborhoods, according to a UAB study.
UAB researchers will use pressures greater than those found at the center of the Earth to potentially create as yet unknown new materials. In the natural world, such immense forces deep underground can turn carbon into diamonds, or volcanic ash into slate.
UAB has received a BRAIN Initiative grant of $7.3 million from NIH to study new technology that could improve outcomes from deep brain stimulation. UAB investigators will assess next-generation DBS technology which can direct current in specific directions in the brain, allowing for a more tailored approach to DBS.
New research says calcium supplements may not be heart-healthy, but UAB cardiologists are saying there is no reason to panic.
Parents’ driving distracted is a significant danger, and a UAB study suggests suburban and rural parents use cellphones with children in the car.
Moon Nahm’s groundbreaking research is on the threshold of aiding researchers in producing vaccines at prices that will propel their widespread use and help protect the estimated 1.6 million children, most of them under the age of 5, who die yearly from S. pneumoniae infections.
A fight with breast cancer has brought Odenville Elementary teachers Meg Lowry and Michelle Simmons closer as they learn the disease is “not your grandmother’s story anymore.”
Jianguo Gu has unraveled how sensory information that is processed in the Merkel discs in fingertips is conveyed to the ending of a sensory nerve, the start of its journey to the brain. Such molecular understanding may help to treat the pain called tactile allodynia
Almost 100 people have signed up for the annual Komen Race for the Cure in honor of Physical Medicine and Rehabilitation’s Yvonne Akins, a mentor and friend to many at UAB for 42 years.
UAB researchers want to introduce Alabama cancer survivors to a new kind of therapy — gardening.
A new study suggests many patients at risk for suicide would voluntarily place their name on a Do Not Sell list, prohibiting gun shops from immediately selling them a firearm.
Patients using Botox A for urinary incontinence show higher satisfaction with treatment due to greater reduction in bothersome symptoms.
Researchers at UAB have launched the first drug study aimed at preventing or delaying the onset of epilepsy in children with a genetic condition known as tuberous sclerosis complex.
A study by scientists at UMass Medical School and UAB provides insight into the mechanism of action of the drug ataluren, which is showing promise in treating Duchenne muscular dystrophy and cystic fibrosis.
The National Eye Institute has awarded UAB’s Jason Nichols and colleagues a $1.9 million grant for dry eye research that could lead to a targeted therapy.
The evidence found suggests the earliest ancestors of modern sea turtles may have come from the Deep South.
Older adults can develop cardiovascular risk factors later in life, according to a study from UAB.
The change of practice in C-section delivery improves the health of mom and baby.
To prevent heart failure and restore heart function, researchers will work to create a bioengineered, human heart-tissue patch that is large, standardized and highly functional. This preclinical work will be supported by a seven-year grant just awarded by the NHLBI.
A UAB-crowdfunded study to provide naloxone kits to family and friends of at-risk opioid users has distributed more than 100 kits and has seen nine overdose reversals since it began in November 2015.
Cells use specific proteins that help the cell remember what collection of genes needs to be turned on again after cell division. Removing these transcriptional bookmarks may be a key to better reprogramming of human fibroblasts to create induced pluripotent stem cells, or iPSCs.
Complications of diabetes can lead to blindness, yet only 29.9 percent of diabetic patients studied adhered to recommendations to have an eye examination.
The BrightFocus Foundation has awarded a glaucoma research grant of more than $149,000 to J. Crawford Downs, Ph.D., of the University of Alabama at Birmingham, for his work on a new wireless system to measure and control fluid pressure around the optic nerve.
Exercise is a key to better health, and UAB is teaming up with local partners to encourage people to get outside and be active in their local parks.
Amounts of a microRNA are significantly elevated in the brains of experimental rats with induced depression, in the post-death brains of humans diagnosed with major depressive disorder and in peripheral blood serum from living patients with MDD.
Clinical and epidemiological data are combined with sociology and anthropology to better understand preterm birth in the United States compared to Canada, the United Kingdom and other Western European countries.
In preclinical work begun this year, stealth insulin-producers — pancreatic islets from pigs or mice coated with thin bilayers of biomimetic material — are being tested in vivo in a mouse model of diabetes.
UAB clinical psychologist Josh Klapow, Ph.D., discusses the importance of evaluating activities and setting ground rules to keep from getting overbooked.
UAB pediatric neurosurgeons are working with their Vietnamese counterparts to improve epilepsy care in Vietnam as part of the Global Surgery Program at UAB and Children's of Alabama.
In a study of children with brain shunts at Children’s of Alabama, a University of Alabama at Birmingham investigational biomarker outperformed the current “gold standard” test for detecting bacterial infections in the shunts.
UAB doctors say new research is showing that patients who suffer from isolated mitral valve regurgitation may need surgery before symptoms appear.
Researchers show that the well-known mechanism of gene expression control — dynamic changes in DNA methylation — is also involved in changes to the excitability of neural cells. The sites of such methylation changes may offer a potential therapeutic target in neuropsychiatric disorders.
Investigators at UAB have identified an intriguing potential treatment target for the most common form of Guillain-Barré syndrome. In a new study, the authors offer evidence of a crucial pathogenic role for a molecule that is associated with AIDP, the most common variant of Guillain-Barré syndrome.
A study has found that people who remained sedentary after mentally demanding tasks consumed more calories than those who exercised.
Articles published today by UAB and its Geroscience Network collaborators explore new interventions in aging processes as part of an effort to increase the healthy, independent years of life for the elderly.
Sedentary behavior — even among physically active people — may be associated with an increased risk of heart disease, diabetes and more.
UAB presents New Frontiers of Pain Research in the 21st Century, Oct. 14-15.
A UAB urologist has led the development of extensive guidelines of surgical management of kidney stones.
A wearable cloud make the design of mobile and wearable devices simple, inexpensive and lightweight by having mobile device users tap into the resources of the wearable cloud, instead of relying solely on the capabilities of their mobile hardware.
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