Researchers from University Health Network have developed and validated an innovative deep learning model to predict a patient’s long-term outcome after receiving a liver transplant.
Case done at University Health Network is believed to be a first in Canada on a patient whose lungs were irreparably damaged by COVID-19
For the first time, an app has been shown to reduce key symptoms of chronic pain. A UNH-led study evaluated the impact of Manage My Pain(MMP), a digital health solution on chronic pain patients.
An Ontario network of Spinal Cord Injury (SCI) rehabilitation sites and patient partners, committed to raising the standard of SCI rehabilitation care, is expanding across Canada, to ensure equitable, optimal care for all patients, regardless of where they live.
Results of a world-first Canadian pilot study on patients treated with gene therapy for Fabry disease show that the treatment is working and safe.
Creating “super soldiers” of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers.
Dr. Heather Ross launches a clinical study, with Apple to test if remote monitoring with Apple Watch can help with early identification of worsening heart failure. Data collected using an Apple Watch will be compared to data routinely collected from rigorous physical tests patients normally undergo.
Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML) – called NPM1 – that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation.
Stand Up to Cancer Canada Dream Team is combining strengths of Princess Margaret, SickKids, University of Toronto researchers, and other unique partnerships, to accelerate new cures for hard-to-treat cancers, such as glioblastoma.
A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year.
Unpacking biomedicine, traditional knowledges and healing practices though oral storytelling and visualizations to support First Nations, Inuit and Métis in making informed choices.
Results of a multi-centre, international, clinical trial co-led by Peter Munk Cardiac Centre (PMCC) cardiologist Dr. Dinesh Thavendiranathan point to the benefit of using a more sensitive test to detect heart function issues early, so cancer patients don’t have to fight heart failure too.
More than half the clinicians surveyed at the Peter Munk Cardiac Centre reported burnout and high levels of distress according to a series of studies published today in the Canadian Medical Association Journal Open (CMAJ-OPEN). In these studies carried out before the COVID-19 pandemic, 78% of nurses, 73% of allied health staff and 65% of physicians described experiencing burnout.
Princess Margaret Scientist Dr. Catherine O’Brien and team discovered that cancer cells hijack an evolutionary conserved program to survive chemotherapy. Furthermore, the researchers show that novel therapeutic strategies aimed at specifically targeting cancer cells in this slow-dividing state can prevent cancer regrowth.
Research led by Princess Margaret Radiation Oncologist Dr. Alejandro Berlin showed that virtual care can be implemented rapidly and safely across a highly-specialized and high-volume cancer centre. Eighty (80) per cent of patients reported they were either very satisfied or satisfied with it, citing convenience as a main factor, with 72 per cent of physicians reporting similar satisfaction with it.
New research from UHN’s Peter Munk Cardiac Centre (PMCC) shows statins, commonly prescribed to lower cholesterol and reduce the risk of heart disease and stroke, may also protect the heart from damaging side-effects of early breast cancer treatment.
Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19 patients requiring intensive care unit (ICU) support, full dose anticoagulation drugs did not improve outcomes. Enrollment continues for moderately ill hospitalized COVID-19 patients in the trials.
University Health Network (UHN) today gave the first COVID-19 vaccine in Canada. This landmark event signals a potential turning point in the pandemic and underlines the value of science and worldwide cooperation.
Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells.
In a study published today in Scientific Reports, a Nature Research Journal, a team of researchers led by Dr. Joseph Fisher presents a proof of concept of a simple method that could become a game-changer in rescue therapy for severe alcohol intoxication, as well as just “sobering up.”
Ancient embedded elements in our DNA from generations past can activate a powerful immune response to kill cancer cells like an infection.
In an article published in Nature on October 14, 2020, scientists at Princess Margaret Cancer Centre, University of Toronto, Stanford University, Johns Hopkins, Harvard School of Public Health, Massachusetts Institute of Technology, and others, challenge scientific journals to hold computational researchers to higher standards of transparency, and call for their colleagues to share their code, models and computational environments in publications.
One in five Canadian adults is currently living with arthritis, a disease causing inflammation of the joints, which can result in chronic, debilitating pain, reduced mobility and premature disability. Arthritis is the leading cause of disability globally. To address this growing crisis, the Schroeder Arthritis Institute, launched with a $25 million donation by philanthropists Walter and Maria Schroeder, will help UHN’s innovative arthritis program become a world-class hub for innovation in research, education and patient care.
The Ted Rogers Centre for Heart Research, at the Peter Munk Cardiac Centre (University Health Network) are collaborating with Apple, Inc., to give heart failure patients even more control over their health, and usher in a new era of remote monitoring possibilities.
An international, first-of-its-kind cardiology trial used personalized genetic testing to reduce by 34 per cent the number of serious adverse events following balloon angioplasty, a treatment for the most common form of heart disease.
Taking advantage of a cancer cell’s altered metabolism that drives its runaway growth, Princess Margaret researchers are zeroing in on these molecular changes to help them develop more precise drug targets for one of the most deadly breast cancers.
A test which detects changing levels of tumour fragments in the blood may be an easy, non-invasive and quick way to predict who will benefit from immunotherapy, a treatment option for advanced cancers.
Medical cannabis is finally being put under the microscope, in a first-of-its-kind real world evidence study led by Dr. Hance Clarke, Toronto General Hospital. In the Medical Cannabis Real-World Evidence trial patients using the online portal created by Medical Cannabis by Shoppers, will know exactly what is in their product and its effectiveness.
Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.
Dr. Eugene Chang was 25, recently engaged and halfway through a physical medicine and rehabilitation residency in Vancouver when he started feeling sick. Fatigue, dizziness and nausea took over his normally active lifestyle. Suddenly his bike to work was not so easy.
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