A comparison of two of the most common combination therapies for locally advanced prostate cancer show the more aggressive option is linked with a higher rate of survival.
Separated entry and exit doors for calcium keep energy production smooth in the powerhouses of heart cells.
Older adults can help boost their memory and stay independent longer, with a little help and motivation.
A behavioral treatment that helps adults set goals toward a more active social, cognitive, and physical lifestyle can reduce memory decline, in a randomized controlled trial.
New research reveals patients with end-stage ankle arthritis can expect enhanced quality of life within six months of surgical reconstruction.
Blocking nuclear gateways that traffic cancer-promoting molecules to nucleus, could offer a new way to target aggressive cancer.
First Optimizer® Smart investigational device for heart disease implanted in the Philadelphia Area
The innate NK-cell response requires a rather carefully choreographed interaction of three cell types.
Understanding and addressing what patients need from an emergency room encounter could help improve patient care.
As cancers find ways to bypass a new therapy, researchers discover the tumor also develops an Achilles heel that can be hit with a different cancer therapy.
Lab tests demonstrate that a hydrogel could help repair damaged spinal nerves that control breathing, an advance that could eventually be developed into new patient treatment.
A novel digital health device could help clinicians remotely monitor side effects of lung cancer patients undergoing radiation therapy.
Scientists from the Sidney Kimmel Cancer Center (SKCC) at Jefferson Health will be presenting research and leading discussions on various topics, including metastatic uveal melanoma, genetic counseling in men, immunotherapy in early stage lung cancer and solid tumors, quality of life among patients receiving treatment for T cell lymphoma and updates on the Cancer Moonshot during the Biden Cancer Initiative Colloquium at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, being held June 1-5 in Chicago.
Visualizing the signals that make brain cells connect reveals new insights into the developing brain.
A CAR-T-based immunotherapy successfully kills tumors and prevents metastatic growth, in final preclinical tests before human trials.
To improve the impact of outreach efforts, researchers develop a better way to identify areas with high risk patients
Using advanced imaging technology, researchers observe new patterns of molecular organization as connections between neurons strengthen during learning.
To explore causes of hospital readmissions, researchers created a tool to identify and quantify a patient’s feelings of uncertainty during their initial emergency department visit.
Computer-aided surgery facilitates complete cancer removal for difficult pelvic tumors
Six regional health systems today announced the founding of a nonprofit clinical research consortium – Partners in Innovation, Education, and Research (PIER Consortium™) – a streamlined clinical trial system that will span New Jersey and Pennsylvania.
Non-small cell lung cancer Nanoparticles pass the next stage of development in preclinical tests.
Patients treated for heart attack were 48 percent less likely to have a sudden return to the hospital when educated using a multi-factored discharge and follow-up program
Optimizing the timing of targeted therapies for melanoma reverses tumor growth, and resistance can be mitigated.
The most common gene mutation associated with Parkinson’s alters cells circulating outside the brain, not within, offering a new understanding of what causes the disease.
Increasing the body’s ability to produce lipids in the lungs after damage prevents the progression of pulmonary fibrosis in preliminary studies.
Replenishing a naturally occurring heart protein could improve stem cell therapy after a heart attack
A novel antibody-based therapy that blocks the excessive formation of collagen clusters is safe and effective in multiple animal models of fibrotic disease
Bursting oxygen-filled microbubbles in breast cancer makes tumors three times more sensitive to radiation therapy in preliminary tests with animal models of the disease
Contrary to long-established dogma, the eye can host an active immune response that could both heal injury and contribute to loss of vision.
Next-generation Genomic Sequencing could help identify infecting organisms and guide treatment for patients with joint-replacement infection
An international panel of experts has created a roadmap to help identify which men and their families may benefit from genetic evaluation for inherited prostate cancer.
New research shows how losing a ubiquitous gene opens genetic floodgates that make prostate cancer deadly, a finding that could apply to many cancers.
An antibody therapy against a key inflammatory molecule involved in migraines reduces the number of headaches that chronic migraine patients experience per month in a phase III trial.
Researchers identify several lncRNAs that are linked to the ovarian cancer in a cohort of patients. These lncRNAs were reproducibly altered and are responsible for a shift in cellular function that contributes to the metastatic properties of the cancer cells.
Using a different marker to track a patient’s glycemic levels could help improve outcomes after surgery for diabetic and non-diabetic patients alike.
Patients showed a reduction in measures of frailty after surgery for left-ventricular-assist-device (LVAD)
A novel computational method allows researchers to parse how multiple organs contribute to a disease over time, giving a more holistic view of disease and potentially revealing new avenues for intervention.
The cerebellum is activated in patients using the neuro-emotional technique (NET) to alleviate stress from traumatic cancer-related memories.
Nursing students who spent their community rotation in a maximum security prison began to appreciate the complex life-experiences that impact the health of the individuals they serve.
A collaboration among research institutions, private industry, and the US Government will develop a tetravalent vaccine to protect against four viruses that can be fatal
A new meta-analysis shows that pregnant women with endometriosis are at greater risk for a host of complications during pregnancy and at delivery, including preterm birth and cesarean section.
Researchers at Jefferson’s Maternal Addiction Treatment Education & Research (MATER) program found significant improvement in the quality of parenting among mothers who participated in a trauma-informed, mindfulness-based parenting intervention while also in medication-assisted treatment for opioid use disorder. Results of the study, the first to scientifically test a mindfulness-based parenting intervention with this population, were published July 27 in the Journal of Addiction Medicine.
Discovery of a phosphorylation event outside of the cell offers new avenue for targeting chronic and pathologic pain, a new study reports
A new treatment rapidly removes the oral blood thinner dabigatran (PRADAXA®) from circulation within minutes, allowing life-saving clots to form normally
Many neurological diseases are malfunctions of synapses, or the points of contact between neurons that allow senses and other information to pass from finger to brain. In the brain, there is a careful balance between the excitatory synapses that allow messages to pass, and the inhibitory synapses that dampen the signal. When that balance is off, the brain becomes unable to process information normally, leading to conditions like epilepsy. Now researchers at Jefferson have discovered a molecule that may play a role in helping maintain the balance of excitatory and inhibitory neurons. The results were published in the journal eLife.
Most cases of Parkinson’s have no known cause, and researchers continue to debate and study possible factors that may contribute to the disease. Research reported in the journal npj Parkinson’s Disease suggests that a certain strain of influenza virus predisposes mice to developing pathologies that mimic those seen in Parkinson’s disease.
Blood thinners, such as aspirin, reduce the risk of thrombus formation but also interfere with the initial clot formation that is essential for preventing blood loss from the wounds. Now researchers have discovered that a molecule plays a role in thrombus development, but not the initial clot formation, suggesting a new avenue for developing more specific and protective blood thinners.
Sleep is important, but if there is something more important or interesting to do—for example, taking care of a baby, finishing a grant proposal before a deadline, or reading a fascinating book—we may stay up late. Sleep in fruit flies is a lot like human sleep, and like humans, flies can keep themselves awake if there is something important to do. In research published on May 16th in eLife, researchers report discovery of neurons that allow male fruit flies to suppress sleep so they can court female flies.
New research published May 4 in the New England Journal of Medicine demonstrated that a buprenorphine can safely cut the duration of therapy nearly in half for infants withdrawing from opioids.
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