Mutation in Tumor Suppressor Gene Causes Pancreatic Islet Cells to Reproduce
Perelman School of Medicine at the University of PennsylvaniaResearchers have found that the acute loss of a protein called menin can cause the proliferation of pancreatic islet cells. The menin gene (Men1) mutation in humans causes an inherited disease called Multiple Endocrine Neoplasia type 1 (MEN1). Not only could this discovery inform basic cancer biology, it also has implications for treating Type 1 diabetes.