Thomas Jefferson University’s new web-based resource, HandsFree, makes the task of analyzing your next-generation sequencing data easy.
Research from Thomas Jefferson University is laying the foundation for a genetic test to accurately identify hip dysplasia in newborns so that early intervention can be initiated to promote normal development. Researchers studied four generations of a Utah family affected by developmental dysplasia of the hip (DDH) in most generations to determine the genetics of DDH. Their findings are currently available in the Journal of Bone and Mineralizing Research (JBMR) online.
Patients with cancer that has spread to their bones are often treated with radiation therapy to reduce pain. But if that treatment doesn’t work, or can’t be used again, a second, effective option now exists. Results of a clinical trial on the new therapy, presented by a researcher at Jefferson’s Kimmel Cancer Center, is being presented at the annual meeting of the American Society of Clinical Oncology (ASCO).
The HER2 growth-factor gene is known to be over-active in breast and gastro-esophageal cancers. But now, irregularities in the genes ‘s expression — among them mutations, amplifications, substitutions, and translocations — have been found in 14 different advanced solid tumors.
Experts from the Department of Pulmonary and Critical Care Medicine at Thomas Jefferson University Hospital are available to comment on issues related to lung cancer screening and diagnosis, and development of pulmonary fibrosis, specifically at the American Thoracic Society International Conference in Philadelphia, its home, May 17-22.
Third-year residents in the Department of Family and Community Medicine at Thomas Jefferson University Hospital have organized a symposium examining racial and ethnic health disparities, with a focus on cancer care. The program will feature a keynote speech from Otis Brawley, MD, Chief Medical Officer of the American Cancer Society.
Thomas Jefferson University Hospital was recently bestowed the title of “Quality Respiratory Care Institution” (QRCR) for 2013 by the American Association for Respiratory Care. This designation is given to those facilities that have shown a commitment to quality and provide a level of respiratory care consistent with national standards and guidelines.
An international group of investigators, led by researchers at Thomas Jefferson University’s Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells contain abnormally high levels of the pro-growth protein Stat5.
This study confirms that VEGF is not a path forward to tackling this disease.
The Kimmel Cancer Center (KCC) at Jefferson will host a survivorship conference, “Cancer Survivorship: The Future Is Now” on Friday, April 12th from 12 to 2 PM. The conference will feature a keynote speech from Mary S. McCabe, RN, MA, director of the Cancer Survivorship Program at Memorial Sloan-Kettering Cancer Center (MSKCC) as well as breakout sessions on “Nutritional Information to Support Your Survivorship,” “Women’s Sexuality: Reclaiming your Sexual Self” and “The Sex Factor: Men and Sex After Cancer” to address men’s and women’s sexuality after a cancer diagnosis.
A review of all 21 of the National Comprehensive Cancer Network (NCCN) member institutions found that only four provided nutritional guidelines, with seven linking to external sites. What’s more, many of the sites with recommendations contradicted each other.
Infections, as the news has shown time and again, can be deadly. Periprothesthetic joint infection (PJI) is the infection of grave concern to the orthopedic community, especially in its growingly common antibiotic-resistant form. Javad Parvizi, MD, and colleagues at the Rothman Institute at Jefferson have worked for years to find a solution to this sometimes deadly infection. Their most recent work has attempted to determine the optimal thresholds for two common biomarkers for systemic inflammation and infection.
Platelet rich plasma (PRP) therapy has been used to manage pain associated with torn tendons, muscles and ligaments, mostly in athletes, at all levels. Though it has anecdotally been successful, the evidence to support its efficaciousness is weak. Researchers at the Rothman Institute at Jefferson participated in a multi-center randomized prospective study to evaluate the clinical value of PRP versus an active control group to determine its effectiveness in managing the pain and tenderness associated with tennis elbow.
Physician-researchers at the Rothman Institute at Jefferson have developed a new, clinically meaningful scale of severity for diagnosing patients with cervical spinal stenosis. Their goal was to create a more accurate scale than the current “mild, moderate or severe” designations used for patients with this condition, a narrowing of the spinal canal in the neck. Researchers sought to create a reproducible, clinically validated classification of central cervical stenosis.
Takami Sato, M.D., named first K. Hasumi Professor in Medical Oncology.
Internationally renowned breast cancer researcher and clinician Massimo Cristofanilli, M.D., FACP, has been appointed Director of the Jefferson Breast Care Center at the Kimmel Cancer Center and Thomas Jefferson University and Hospitals.
Jefferson’s Kimmel Cancer Center opens first-of-its-kind trial to investigate calorie reduction in combo with radiation therapy.
Patients three times more likely to get screened for colon cancer with phone navigation and mailings, researchers at Jefferson’s Kimmel Cancer Center found.
Low screening rates and lack of treatment resulting in late-stage diagnoses, poor outcomes in prostate cancer patients in Ghana
Clever intervention designed by a pharmacologist, a general practitioner and a biostatistician substantially reduced the prescribing of potentially dangerous medications. Reporters' conference call on January 23 at 9:30 EST The study’s three co-authors, Vittorio Maio, PharmD, MS, MSPH (a Jefferson pharmacology expert); Scott Keith, PhD (a Jefferson biostatistician); and Stefano Del Canale, MD, PhD (a practicing physician in Parma) will discuss their work. The dial-in telephone number is: +1-866-818-8556 Access Code: 5430707
A groundbreaking study lead by William B. Young, MD, a neurologist at Thomas Jefferson University Hospital’s Headache Center, shows that patients with migraine (a combination of severe headache, nausea, light sensitivity, and other factors) suffer social stigma from their disease similar to the stigma experienced by patients with epilepsy.
Thomas Jefferson University researchers lead group that developed guidelines for early-stage development of radiosensitizers.
Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients.
Researchers at the Kimmel Cancer Center at Jefferson have developed potentially game-changing diagnostic and prognostic genetic tests shown to better predict prostate cancer survival outcomes and distinguish clinically-relevant cancers.
Mark Hurwitz, M.D., has been appointed Vice Chair for Quality, Safety, and Performance Excellence and Director of Thermal Oncology of the Department of Radiation Oncology at Thomas Jefferson University and Hospital.
Jefferson Medical Care – South Philadelphia, a primary care practice, has received accreditation from the National Committee for Quality Assurance (NCQA) as a Patient-Centered Medical Home, showing its commitment to evidence-based, patient-centered care that focuses on coordinated and long-term collaborative patient-physician partnerships.
GM1 ganglioside slowed progression of disease in patients over at least a two-year period.
Cancer and stress go hand-in-hand, and high stress levels can lead to poorer health outcomes in cancer patients. The Jefferson-Myrna Brind Center of Integrative Medicine combined creative art therapy with a Mindfulness-based Stress Reduction (MBSR) program for women with breast cancer and showed changes in brain activity associated with lower stress and anxiety after the eight-week program. Their new study appears in the December issue of the journal Stress and Health.
Two-day symposium Nov. 29 and 30 will focus on individualized medicine.
Thomas Jefferson University researchers have shown that a real-time tracking technique can better predict and track tumor motion and deliver higher levels of radiation to lung cancer patients and others with moving tumor targets, and also successfully be implemented into existing clinical equipment.
Take off those Thanksgiving pounds with a week at a spa retreat. A new study shows that not only are they relaxing and nourishing, but are they safe and a week-long spa stay can correspond with marked changes in our physical and emotional well-being.
Researchers at Thomas Jefferson University and the University of Sao Paulo in Brazil analyzed the cerebral blood flow (CBF) of Brazilian mediums during the practice of psychography, described as a form of writing whereby a deceased person or spirit is believed to write through the medium’s hand. The new research revealed intriguing findings of decreased brain activity during mediumistic dissociative state which generated complex written content. Their findings will appear in the November 16th edition of the online journal PLOS ONE.
Research from the Rothman Institute at Jefferson has shown aspirin to be just as effective as warfarin in preventing clots, specifically pulmonary emboli, life-threatening blood clots that can develop in the arteries of the lungs following joint replacement surgery. Their research was recognized as one of the best poster presentations at the recent American Association of Hip and Knee Surgeons (AAHKS) meeting in Dallas.
Implementing measures to ensure radiation therapy protocols are followed not only decreases deviations, but it can also improve overall survival in cancer patients, Thomas Jefferson University Hospital researchers suggest in a first-of-its kind study presented during a plenary session at the American Society for Radiation Oncology 54th Annual Meeting in Boston.
Researchers at the Jefferson Institute of Molecular Medicine were awarded almost $384,000 by the National Institutes of Health to investigate the mechanisms involved in the development of a serious and sometimes fatal disease, known as Nephrogenic Systemic Fibrosis, a rare skin disorder linked to Gadolinium-based contrast agents used in magnetic resonance (MRI and MRA) studies.
Scott Waldman, M.D., Ph.D., chairman of the Department of Pharmacology and Experimental Therapeutics at Thomas Jefferson University, has been awarded one of the prestigious “Provocative Questions” grants from the National Cancer Institute (NCI) , as part of the Institute’s ambitious program to tackle the “important but not obvious” questions in cancer to ensure no stone was left unturned after decades of promising research.
(PHILADELPHIA) – Researchers at Thomas Jefferson University Hospital have shown that combining distal protection devices with the prophylactic use of the drug nicardipine is more effective at preventing life-threatening complications following a percutaneous coronary intervention (PCI) (angioplasty, stenting) on patients who have undergone previous bypass surgery than distal protection devices alone.
Men who had high levels of the activated Stat5 protein in their prostate cancer after a radical prostatectomy were more likely to have a recurrence or die from the disease compared to men who had little to no presence of the growth protein, according to a recent study published in Human Pathology by Jefferson’s Kimmel Cancer Center researchers.
Researchers at Thomas Jefferson University Hospital have shown that age 45 is no longer a useful predictor of negative outcomes in the staging of papillary thyroid cancer patients. Their findings were among the most impactful abstracts recently presented at the American Thyroid Association annual meeting in Quebec City, Quebec, Canada.
Restoring diminished levels of a protein shown to prevent and reverse heart failure damage could also have therapeutic applications for patients with critical limb ischemia (CLI), suggests a new preclinical study published online October 9 in Circulation Research from researchers at the Center for Translational Medicine at Thomas Jefferson University.
Targeting dual roles of PARP-1 may slow cancer growth and progression, Jefferson’s Kimmel Cancer Center researchers say.
T regulatory cells in the pancreatic lymph nodes play important role in diabetes onset and recovery of the insulin production in diabetic patients, say Thomas Jefferson University researchers
Contrast-enhanced ultrasound was found to better detect high-grade prostate cancer than conventional methods, making it a more appropriate approach for screening clinically important cancers and monitoring low-risk ones with less biopsies, researchers from Thomas Jefferson University and Hospitals conclude in a phase III study in the November issue of the Journal of Urology.
Key national and international players on the front lines of diabetes research, care and prevention will descend on Philadelphia for the First Annual Diabetes Symposium: New Advances and Innovations, a one-day symposium on advancing patient care on Friday, September 28, from 7:30 am to 5:30 pm in the Dorrance H. Hamilton Building, Connelly Auditorium on the Thomas Jefferson University campus.
A preclinical study published in PLOS ONE September 19 by Thomas Jefferson University researchers found that decorin, a well-studied protein known to help halt tumor growth, induces a series of tumor suppressor genes in the surrounding tissue in triple negative breast cancer tumors to help stop metastasis.
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