With only 13 genes, human mitochondria are massively overshadowed by the 20,000 genes in the human nucleus. Nevertheless, these diminutive organelles may have a strong influence on cellular metabolism and susceptibility to metabolic diseases like heart failure or obesity.
Scientists have found that a single-dose of the oral antibiotic zoliflodacin successfully treated uncomplicated genital infections caused by gonorrhea, according to research published in The New England Journal of Medicine.
According to the authors, genetic counselors represent a unique resource for the public, patients and other medical professionals and should be more fully incorporated into the health care setting.
In research to improve influenza therapies against H7N9 and other influenza strains, Chad Petit and colleagues have detailed the binding site and mechanism of inhibition for two small-molecule experimental inhibitors of influenza viruses. Their report is published in the Journal of Biochemistry,
Nearly 6 million Americans are living with Alzheimer’s disease and 16.1 million Americans provide unpaid care for people with Alzheimer’s or other dementias, accounting for an estimated 18.4 billion hours of care. As part of Alzheimer’s Awareness Month in November, UAB geriatricians provide tips, ideas and best practices to help family caregivers care for a loved one living with Alzheimer’s or dementia, while also keeping the patient and the caregiver safe and sane. The tips include ways to talk about major decisions, such as taking away the keys or moving someone to a new home, as well as ideas to allow the patient to stay safe while continuing to live with dignity and feel valued in their community.
A new study from UAB describes the impact of a peer coach intervention on hospitalizations and emergency room visits for individuals with diabetes and depression.
A research team led by UAB is launching a study to find a better model for glioblastoma, a particularly devastating type of brain tumor, to help determine the most appropriate treatment modality.
Rachael Lee, M.D.In a retrospective cohort study conducted at the University of Alabama at Birmingham Division of Infectious Diseases, patients with candidemia — a yeast infection in the bloodstream — had more positive outcomes as they relate to mortality when infectious disease consultation, or IDC, occurred during their hospital stay.
UAB transplant surgeon Jayme Locke recently shared six steps to building a dream career. To be a surgeon, you have to have confidence. “I tend to be grandiose in my thinking,” said Jayme Locke, M.D., MPH, director of the University of Alabama at Birmingham’s Incompatible Kidney Transplant Program and vice chair for Health Services Research in the Department of Surgery.
UAB experts can comment on the preparation, response and recovery related to Hurricane Michael and how it may impact schools, businesses, hospitals, communities and more.
Children and adolescents are at higher risk of developing mental health problems from abuse, but the severity of mental health problems greatly depends on the timing of abuse.
There is a missing link between genetic and environmental causes of Parkinson’s disease, speculate scientists at UAB, and armed with a $2.5 million grant from the U.S. Army Medical Research and Materiel Command, they intend to find it.
For 12 months, UAB physics graduate student Ashlyn Burch will work at Sandia National Laboratory, high in the semi-arid Western city of Albuquerque, New Mexico, supported by a U.S. Department of Energy Science Graduate Student Research award.
For many cancer patients, high-intensity treatments such as intubation and ICU admission are administered during their end-of-life care, but little is known about whether that care is in line with a patient’s wishes and treatment goals.
Modifying games, including all students and ensuring safety should be the focus for physical educators as they teach kids key motor, fitness and social development skills.
The last thing anyone wants to hear, as National Coffee Day approaches Sept. 29 and stores offer celebratory discounts, is something negative about America’s favorite brew.
In proof-of-concept experiments, researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. Researchers deliver a therapeutic enzyme via the cellular equivalent of a Trojan Horse, using platelets to protect the key enzyme hidden inside.
Attention has focused on how NSAIDs may cause dysfunction of the immune system. Researchers now have found that sub-acute pretreatment with the NSAID carprofen before experimental heart attack in mice impaired resolution of acute inflammation following cardiac injury.
Women with ovarian or endometrial cancer who followed the ketogenic diet for 12 weeks lost more body fat and had lower insulin levels compared to those who followed the low-fat diet. Researchers say ketogenic diets limit the ability of cancer to grow, which gives the patient’s immune system time to respond.
For people with the genetic disorder neurofibromatosis type 1, a three-base pair deletion in the NF1 gene has a mild phenotype, but the mutation causes complications that include non-optic brain tumors, mostly low-grade and asymptomatic, as well as cognitive impairment and/or learning disabilities.
In a paper published in the journal Science, researchers have detailed a mechanism that sets the stage for the fate decision that gives rise to two major subsets of effector cells: T follicular helper cells and non-T follicular helper cells, known as Tfh and non-Tfh cells.
In mouse experiments, scientists have shown a way to hit an immunological “reset button” that ends inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure.
Researchers have found a mechanism that links epigenetic changes to translational control during fear memory reconsolidation — several particular epigenetic changes in the hippocampus of the rat brain control downstream regulation of translation in brain neurons, acting through a gene called Pten.
Researchers have developed and tested 30 quantitative assays for pig infectious agents. The assays had sensitivities similar to lab assays for viral loads in human patients. After validation, they also used the assays on nine sows and 22 piglets delivered from the sows through caesarian section.
A study comparing two breathing tubes used by paramedics during out-of-hospital cardiac arrest shows that the King laryngeal tube was superior to the more commonly used endotracheal tube, according to findings of the Pragmatic Airway Resuscitation Trial.