Researchers have found an enzyme in the blood that could be a marker for heart failure. They previously showed that GRK2 is increased in failing human hearts and contributes to the heart losing contractile strength. Using tissue samples from heart failure patients, they found they could track heart levels of GRK2 in the blood.
Researchers have found a way to create a permanent chemical bond between antibiotics and titanium, which is used in implants. They showed that an antibiotic can be connected to the titanium surface in an active form, and can kill bacteria and prevent infection.
Researchers have identified a gene defect in mice resulting in a range of abnormalities, from hair loss and skin cancer to problems in skin development. The work may lead to improved treatments for skin injuries, including burns, and might have implications for diseases such as eczema and psoriasis, as well as certain cancers.
Richard G. Pestell, M.D., Ph.D., an internationally renowned expert in oncology and endocrinology, has been named director of the Kimmel Cancer Center at Jefferson in Philadelphia. With this appointment, the cancer programs at Jefferson are being restructured and the role of the cancer center director expanded.
Using transparent zebrafish embryos, researchers have shown that a microscopic nanoparticle can help fend off damage to normal tissue from radiation. The nanoparticle, a soccer ball-shaped, hollow, carbon-based structure known as a fullerene, acts like an "oxygen sink," binding to dangerous oxygen radicals produced by radiation.
Researchers have found that mice with low levels of the protein hormone adiponectin may also have high levels of a protein called albumin which, in humans, may be a sign of kidney disease. This study provides further support for the theory that kidney disease may be a more important risk factor for heart disease than is cholesterol.
By coating the surfaces of tiny carbon nanotubes with monoclonal antibodies, biochemists and engineers at Jefferson Medical College and the University of Delaware have teamed up to detect cancer cells in a tiny drop of water.
Glucosamine, the over-the counter natural product that has been touted to help with joint and cartilage problems associated with arthritis, may also provide some relief to individuals with multiple sclerosis (MS).
If heart disease and diabetes aren't bad enough, now comes another reason to watch your weight. A team has shown that being extremely overweight or obese increases the likelihood of developing Alzheimer's.
Age doesn't necessarily have to be the deciding factor for pancreatic cancer surgery. Jefferson Medical College surgeons and colleagues studied records of pancreatic surgery during the last 35 years at a major academic medical center and found that contrary to what many both in and out of medicine may believe, major pancreatic cancer surgery can successfully be performed on patients in their 80s, 90s and even older.
By demonstrating that a protein called proepithelin plays a crucial role in the spread of bladder cancer, scientists may have identified a potential drug target. They have shown that proepithelin promotes migration and invasion "“ two crucial steps leading to metastasis "“ suggesting that it could be critical for a cancer to become an invasive disease.
Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart. Researchers have shown in studies in both mice and in heart cells in culture that Gleevec can cause heart failure. Not only that, scientists say, other similarly based drugs "“ called tyrosine kinase inhibitors "“ could lead to heart problems as well.
Scientists have staved off heart failure in animals by using gene therapy to shut down the adrenal gland's excessive output of fight or flight hormones such as epinephrine and norepinephrine, which forces the heart to pump too hard. The approach "“ targeting the adrenal gland "“ provides a potential strategy against heart failure, and could lead to new drugs.
The number of spinal cord injuries among senior citizens (age 70 and above) has increased five times in the past 30 years, as compared with younger spinal cord injury patients, researchers at Thomas Jefferson University Hospital and Jefferson's Regional Spinal Cord Injury Center of the Delaware Valley recently reported.
Movement researchers at Thomas Jefferson University Hospital, Philadelphia, are spearheading a new clinical trial to test a new anti-Parkinson's drug in an attempt to decrease off-time experiences and extend L-dopa's effectiveness.
Researchers of the heart and headaches at Thomas Jefferson University Hospital are combining efforts to determine if a common heart defect may be the cause of some forms of migraine headaches.
Former U.S. Secretary of the Treasury Paul O'Neill will address the graduating classes at the annual commencement exercises for Jefferson Medical College and Jefferson College of Graduate Studies.
Performing less invasive laparoscopic surgery using robotic technology may improve survival rates for prostate cancer patients, according to a study by urologic oncologists at Thomas Jefferson University Hospital's multidisciplinary Genitourinary (GU) cancer center.
Researchers at Jefferson Medical College have shown that capsule endoscopy is effective in diagnosing gastrointestinal bleeding and small bowel Crohn's disease in children.
Obesity may contribute to a greater likelihood of post-operative complications for patients having pancreatic surgery, a surgeon at Thomas Jefferson University Hospital has found. A study of 202 pancreatic surgeries from 2000 to 2005 indicates obese patients had an increased time on the operating table, blood loss, length of hospital stay and rate of serious complications compared to normal weight individuals.
The national Acoustic Neuroma Association (ANA), will mark its 25th anniversary at its 18th annual symposium in Philadelphia. The three-day event is scheduled for July 13-15, 2007 at the Doubletree Hotel. The ANA's mission is to inform, educate and provide support for those who have developed these benign tumors, which can cause hearing loss and migraines among other medical problems.
The Advanced Heart Failure and Cardiac Transplant Center at Thomas Jefferson University Hospital has become one of only 96 adult and six pediatric heart transplant centers in the nation approved by Medicare.
An implanted stimulator being studied at Thomas Jefferson University Hospital may be able to predict and prevent seizures before they start in people with uncontrolled epilepsy.
Jefferson Hospital for Neuroscience is one of first medical centers in the U.S. to develop and begin using translational, interactive 3-D technology to map the human brain and help guide neurological surgeons during epilepsy surgery and procedures to remove malignant brain tumors.
Thomas Jefferson University Hospital will host a webcast featuring a mini-Whipple procedure (pylorus preserving pancreaticoduodenectomy) used to treat pancreatic cancer. The webcast, which will feature an actual procedure and panel discussion by the Jefferson Pancreatic Cancer and Related Diseases Team, is scheduled for 4:30 p.m. ET on Tuesday, September 18, at www.JeffersonHospital.org/webcast.
Sleep disorder and ear, nose and throat specialists at Thomas Jefferson University are examining an innovative procedure to treat obstructive sleep apnea syndrome.
Urologists at Thomas Jefferson University Hospital are studying whether a tissue-engineered bladder grown from a patient's own cells can improve bladder control for adult spinal cord injury patients. Jefferson is only one of four sites in the U.S. enrolling participants in this clinical trial for the lab-grown neo-bladder that will involve a total of 10 patients nationwide.
Urologists at Thomas Jefferson University Hospital are studying whether a neo-bladder construct grown from a patient's own cells can improve bladder function for adult spinal cord injury patients. Jefferson is only one of six sites in the U.S. enrolling participants in this clinical trial for the lab-grown neo-bladder construct that will involve a total of 10 patients.
A new guide on pancreatic cancer, co-authored by the chair of Surgery at Thomas Jefferson University Hospital, offers a better understanding to patients and caregivers of the unique challenges associated with a diagnosis of pancreatic cancer
Women with breast cancer often seek immediate breast reconstruction after a mastectomy to help them regain a semblance of their body and for their psychological peace of mind. As part of Breast Cancer Awareness Month in October, Thomas Jefferson University Hospital is re-airing its webcast on one of the most often performed breast reconstruction surgical procedures, using muscle tissue from a patient's back.
Thomas Jefferson University will unveil its newly transformed urban campus to the community during a dedication ceremony on Friday, October 19, 2007, at 11 a.m., just two years after university officials broke ground on the new "heart of the campus."
The holidays can be one the best times of the year, with lights and decorations lifting the spirits and many occasions to be with friends and family. However, for many, it can also be a period of stress and even sadness. Rajnish Mago, M.D., Director, Mood Disorders Program, Jefferson Medical College of Thomas Jefferson University, Philadelphia, offers some tips for determining if you have the blues or something more serious, and how to cope during the holiday season.
If you're planning to hit the streets and sing Christmas carols around the neighborhood during the holiday season make sure to drink plenty"” of water, that is. During cold weather, the air is cold and dry, and in turn, can dry up your voice.
Tears in the aorta which affect thousands of people each year coast to coast, may soon be treated with a much less invasive technique that could dramatically improve patients' chances of survival. A national study being directed by a vascular surgeon at Thomas Jefferson University Hospital is exploring a new minimally invasive method that could spare patients the trauma and risk of open chest surgery.
Marinos C. Dalakas, M.D., a world-renowned expert in neuromuscular diseases, has been named director of the Division of Neuromuscular Diseases in the Department of Neurology and professor of Neurology at Jefferson Medical College of Thomas Jefferson University.
Scientists at Thomas Jefferson University Hospital and Jefferson's Kimmel Cancer Center have received approval for a first-of-its kind study on the effect high dose vitamin C has on non-Hodgkin lymphoma patients. Researchers from the Jefferson-Myrna Brind Center of Integrative Medicine and Kimmel Cancer Center in conjunction with the National Institutes of Health will study whether high doses of vitamin C can slow the progression of the deadly disease.
Thomas Jefferson University has announced the creation of the Jefferson Center for InterProfessional Education. This new center, one of only a few in the nation, is dedicated to improving patient care through coordination, implementation and evaluation of a team-based education curriculum.
Neurological surgeons at Jefferson Hospital for Neuroscience are among the first surgeons in the United States using an FDA-approved liquid system for treating wide-necked brain aneurysms, which could eventually replace current treatments.
A research study has found that a simple blood test may indicate whether post-menopausal hormone therapies present an elevated risk of a heart attack. The study, part of the Women's Health Initiative (WHI), sponsored by the National Institutes of Health, was conducted in 40 centers nationwide and included 271 cases of coronary heart disease in the first four years of the trials.
Scientists at Jefferson Medical College have received a five-year, $11.6 million grant from the National Heart, Lung and Blood Institute to study molecular mechanisms of cardiac injury that lead to heart failure and potential repair processes that occur in the adult failing heart. This project aims to find data that can be translated into novel therapeutic strategies to improve the failing heart.
The summer brings many thunderstorms to the U.S. and Javad Parvizi, M.D., Ph.D., one of the nation's leading joint specialists from the Rothman Institute at Thomas Jefferson University Hospital, says we should believe people who say they can forecast them with their aching joints. He explains the science behind wet weather's affects on the joints of millions and provides information for pain relief.
As beach season gets underway, many people bring their workout regiment with them to the shore. And that means running along the beach, in the sand. It is commonly thought that soft sand better cushions the joints, making running on the beach more beneficial. However, Michael Ciccotti, M.D., chief of Sports Medicine at the Rothman Institute at Thomas Jefferson University Hospital, and head team physician to the Philadelphia Phillies, warns why beach runners should beware.
A clinical study on patients who have suffered a heart attack found that a partially purified extract of Chinese red yeast rice, Xuezhikang (XZK), reduced the risk of repeat heart attacks by 45%, revascularization (bypass surgery/angioplasty), cardiovascular mortality and total mortality by one-third and cancer mortality by two-thirds.
Robert L. Barchi, M.D., Ph.D., President of Thomas Jefferson University announced today the establishment of the Jefferson School of Health Policy and Population Health (JSHPPH), which will begin enrolling students for September 2009.
A research team, led by investigators at the Department of Surgery at Jefferson Medical College of Thomas Jefferson University and the Kimmel Cancer Center at Jefferson, has achieved a substantial "kill" of pancreatic cancer cells by using nanoparticles to successfully deliver a deadly diphtheria toxin gene.
Researchers at the Farber Institute for Neurosciences at Thomas Jefferson University and the Department of Psychiatry and Human Behavior at Jefferson Medical College of Thomas Jefferson University were recently awarded a $3.7 million grant from The National Eye Institute to study depression in patients diagnosed with age-related macular degeneration (AMD).
The Delaware Valley Chapter of the American Liver Foundation Honors Cataldo Doria, M.D., Ph.D., for his Outstanding Service to the Medical Community and to Patients with Liver Disease.
Edith P. Mitchell, M.D., clinical professor, Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University and associate director of Diversity Programs for the Kimmel Cancer Center at Jefferson, was recently honored with a "˜Tree of Life' award from The Wellness of You, a nonprofit health education and resource organization.
Charles J. Yeo, M.D., Samuel D. Gross Professor and Chair, Department of Surgery at Jefferson Medical College of Thomas Jefferson University, announces the establishment of the new Jefferson Pancreas Tumor Registry (JPTR).
Stephen C. Peiper, M.D., appointed Chairman of Pathology, Anatomy and Cell Biology at Jefferson.
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