The study, published in the journal Science, suggests that the harsh climate during the Pleistocene era resulted in the fragmentation of wild ecotypes, which paved the way for the domestication of grapevine about 11,000 years ago in the Near East (Israel) and the Caucasus.
Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable.
Differences in genes involved in inflammation, immunity response and neural transmissions begin in childhood and evolve across the lifespan in brains of people with autism, a UC Davis MIND Institute has found.
Research led by Washington University School of Medicine in St. Louis has identified a possible treatment strategy for a rare bone marrow failure syndrome that is named poikiloderma with neutropenia. The work also may have implications for treating other bone marrow failure syndromes with similar underlying dysfunctions.
Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response.
عادة ما يوجد تكاثر لنوع معين من الميكروبات في الجهاز التناسلي للنساء المصابات يسرطان المبيض، وفقًا لدراسة جديدة من مركز مايو كلينك لنهج الطب الشخصي. إن هذا الاكتشاف المنشور في مجلة التقارير العلمية يقوي الأدلة التي تشير إلى أن المكون البكتيري للحَيُّوم الدقيق - وهو مجتمع من الكائنات الحية الدقيقة يتكون أيضًا من فيروسات وخمائر وفطريات - من المؤشرات الهامة للكشف المبكر عن سرطان المبيض وتشخيصه والتنبؤ بسير المرض.
CHLA researchers launched a liquid biopsy blood test to detect and differentiate between various pediatric cancers less invasively than a tissue biopsy.
Researchers have discovered how a gene that increases the risk of developing genetic heart disease functions, paving the way for new treatments.
Epigenetic changes in the regulation of a key gene in the body’s stress response system were detected in babies and young children with abusive injuries, as opposed to accidental, according to a pilot study published in the journal Pediatric Research.
New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) is the first study to show that childhood obesity is associated with an increased risk of four of the five recently proposed subtypes of adult-onset diabetes.
By inspecting the body’s immune response at a molecular level, a research team has developed a new way to test patients for COVID-19.
Dario Marchetti, PhD, and his team at the UNM Comprehensive Cancer Center found the same common genomic signature in the circulating tumor cells taken from the mice and from the people with melanoma brain metastases. And they found this signature in the circulating tumor cells that were injected in the mice, as well as in cells isolated from a person with melanoma brain metastasis who was undergoing treatment.
National Organization for Rare Disorders (NORD®) Founder and past President Abbey S. Meyers, PhD, former U.S. Rep. Jaime Herrera Beutler of Washington State, New York Yankees centerfielder Bernie Williams, and pioneer clinical geneticist, Dr.Ada Hamosh, headline a group of rare disease champions who will be honored for their outstanding contributions to the rare disease community at NORD's 2023 Rare Impact Awards (RIA).
According to a new study from Rutgers Institute for Health, researchers may be able to predict cardiovascular disease in patients by using artificial intelligence to examine the genes in their DNA.
Scientists know that TDP-43, which helps regulate processing of RNA, may be responsible for the death of nerve cells in ALS and frontotemporal dementia. And a study suggests that a common modification to RNA, a methylation event known as m6A, plays a pivotal role in TDP-43-related neurodegeneration in ALS. Through sequencing analysis, investigators showed that methylation strongly influences the binding of TDP-43 to its RNA targets. They also observed highly abundant RNA methylation in the end-stage tissues of patients with ALS.
New research has uncovered a novel link between the Duchenne muscular dystrophy (DMD) gene and cancer.
Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after age 50, even if they have not been previously diagnosed with cancer.
Let's say you needed to move an individual cell from one place to another. How would you do it? Maybe some special tweezers? A really tiny shovel?
Vascular malformations (VMs), a group of rare genetic disorders that causes an abnormal formation of veins, arteries, capillaries, or lymphatic vessels at birth, can interfere with the duties of our circulatory system by causing blockages, poor drainage, and the formation of cysts and tangles.
Her husband and their five children call Rosa Wernher "the Energizer bunny" because she is always on the go. For decades, not even her genetically inherited Marfan syndrome could keep her off her feet to prevent her from oil painting or from gliding down a ski slope--until it did.
Humans and animals detect different stimuli such as light, sound, and odor through nerve cells, which then transmit the information to the brain.
Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumour called a glioma.
Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after age 50, even if they have not been previously diagnosed with cancer.
Life began on earth more than 3.5 billion years ago, but the history of humans and other vertebrates accounts for only a fraction of this timescale.
The PKD Foundation recently recognized the University of Maryland School of Medicine’s (UMSOM) clinical center that treats polycystic kidney disease (PKD)with a highly prestigious “Center of Excellence” designation. The designation recognizes the center as a leader in providing multidisciplinary, comprehensive clinical services for families affected by autosomal dominant polycystic kidney disease (ADPKD), a hereditary condition. It is one of just 28 clinical centers in the U.S. to receive this recognition.
RNAs are having a moment. The foundation of COVID-19 vaccines, they’ve made their way from biochemistry textbooks into popular magazines and everyday discussions.
While COVID-19 may be transitioning from a “pandemic” to an “endemic” phase, it remains critically important to continue tracking the virus in real-time.
February 28th marks Rare Disease Day – a day designated to driving awareness and change for the more than 25 million Americans and 300 million people worldwide living and struggling with a rare disease. Subject matter experts from the National Organization of Rare Disorders (NORD), America's longest-standing rare disease patient advocacy organization are available to weigh-in on this important public health matter.
Researchers from the Organoid group (former Clevers group, Hubrecht Institute) together with researchers from the Princess Máxima Center for pediatric oncology established novel human organoid models of fatty liver disease.
A decade-long international study into kidney cancer has shown that doctors can predict the likelihood of a patient’s disease returning by looking at DNA mutations in their tumours.
UC San Francisco researchers have uncovered a surprising role for fibroblasts in the lungs in activating T cell inflammation that drives lung destruction in COPD exacerbation triggered by viral infection. They also identified a T cell subset that can be targeted to treat COPD exacerbations.
University of Illinois scientists have found gene variants in deer associated with the animals’ susceptibility to Epizootic Hemorrhagic Disease.
In a new study using mice, University of Maryland School of Medicine researchers were able to tease apart the molecular components involved in abdominal aneurysms to better understand how and why they form.
When scientists disabled a single regulatory gene in a species of sea anemone, a stinging cell that shoots a venomous miniature harpoon for hunting and self-defense shifted to shoot a sticky thread that entangles prey instead, according to a new study.
Archaeologists know that people have practiced cranial trephination, a medical procedure that involves cutting a hole in the skull, for thousands of years.
A new study published in Genes, Brain and Behavior has identified several genetic variants that may be linked with mathematical abilities in children.
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A compound found in cigarette and industrial smoke, benzo(a)pyrene (BaP), is known to damage DNA. Now, researchers reporting in ACS Central Science have mapped these effects for the first time in human lung cells after BaP exposure, which could help predict exposures that lead to cancers.
SHRO Founder Antonio Giordano contributes to a new publication on the use of liquid biopsy to assess the treatment response and find mutations that confer resistance to cancer therapies.
Takeaki Ozawa and his team from the University of Tokyo reveal the metabolic reactions upon activating an enzyme called Akt2. In doing so, they reveal the inner workings of insulin-regulated metabolism.
Of all the known genetic risk factors for late-onset Alzheimer’s disease, the strongest is a gene for the protein called ApoE4.
Researchers from Oregon Health & Science University and institutions across the country have identified a pill used to treat a common skin disease as an “incredibly promising” treatment for alcohol use disorder.
Reporting in the PNAS, UNC School of Medicine researchers made the stunning discovery that telomeres contain genetic information to produce two small proteins, one of which they found is elevated in some human cancer cells, as well as cells from patients suffering from telomere-related defects.
Researchers at UC Santa Cruz working to develop novel RNA-based medicines are teaming up with a new group of collaborators—players of the online game Eterna. The
Regional differences in the spread of Japan’s two main ancestral groups have been revealed, thanks to new research at the University of Tokyo. Japanese people are generally thought to descend from two main groups: Jomon hunter-gatherers and immigrant farmers from continental East Asia.
Every biologist knows that small structures can sometimes have a big impact: Millions of signaling molecules, hormones, and other biomolecules are bustling around in our cells and tissues, playing a leading role in many of the key processes occurring in our bodies.
Iowa State University researchers may have solved a long-standing challenge associated with accelerated development of pure genetic lines.
A team at UNC Charlotte and Tuple, a Charlotte-based genomics consulting firm, has used artificial intelligence to rapidly assess the public health implications of the newly emergent SARS-CoV-2 XBB.1.5 variant. Results from simulations run by the team indicate the antibodies currently in our arsenal are effective to neutralize SARS-CoV-2 XBB.1.5.
In 2017, Vanderbilt University Medical Center was selected to be one of four U.S. medical centers in a Strategically Focused Research Network (SFRN) on Obesity funded by a four-year, $15 million award from the American Heart Association to study obesity and train future obesity-focused investigators.
Betalains are a class of plant pigments that are responsible for the characteristic red-violet (betacyanin) or yellow (betaxanthin) color of certain fruits and vegetables.
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