Anyone newly diagnosed with Crohn’s disease probably has some anxiety about having a chronic ailment for which there’s no cure. A Penn State Health doctor talks about how treatments and medication offer reason for hope.
One of the biggest goals of immunotherapy is to reverse T cell exhaustion to boost the immune system’s ability to destroy cancerous cells. Researchers at Sanford Burnham Prebys studying melanoma have found a new way to make this happen.
The American Society for Investigative Pathology awards Stephen J. Galli, MD, the 2024 ASIP Gold-Headed Cane Award.
Digestive Disease Week (DDW) is the largest international gathering of physicians, researchers, and academics in the fields of gastroenterology, hepatology, endoscopy, and gastrointestinal surgery. DDW2023 will take place May 6-9 in Chicago and showcase 3,100 abstracts and hundreds of lectures on the latest advances in GI research, clinical practice and technology.
Prostate cancer frequently metastasizes to the bone and is incurable. Moffitt Cancer Center researchers are working to identify new treatment options for this subset of patients. In a new article published today in Science Advances, a team of Moffitt scientists demonstrates that chimeric antigen receptor T-cell (CAR T) therapy is an effective antitumor approach in mouse models of bone metastatic prostate cancer.
Immunotherapy has redefined cancer treatment, but not all patients experience the same benefit when treated.
For millions of Americans that suffer from seasonal allergies (pollen and mold), climate change is exacerbating an earlier, longer, and overall worse allergy season.
AAI announces its 2023 Fellowship for Career Reentry
AAI announces 2023 Intersect Fellowships
Researchers have used Argonne’s Advanced Photon Source to characterize a set of broadly neutralizing antibodies effective against a wide range of coronaviruses.
While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection — a discovery that will help better understand the COVID-19 disease and could lead to the development of new antiviral drugs in the future.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.
A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach could also power the development of advanced cell therapies for cancers and other diseases, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
AAI announces its annual Career Awards recipients.
Researchers from Japan have reported the use of an advanced DNA sequencing technique, whole-exome sequencing (WES), to determine why a young child died after a relatively mild infection.
Scientists studying the stubborn and dangerous rare yeast pathogen behind two outbreaks in a neonatal intensive care unit in Delhi, India, have found that while infected patients can be treated with antifungal medications, the yeast is remarkably resistant to the strong disinfectant bleach commonly used to sanitize hospital rooms.
Rutgers issues recommendations for detection of neurologic Lyme disease by rheumatologists
University of Maryland School of Medicine researchers believe they have determined that the immune system whittles away neurons to properly shape the brain and accounts for differences in sizes of regions in male and female rats. These changes later affect behavior of the rats in their personal preferences.
In a new investigation, scientists from La Jolla Institute for Immunology (LJI) have shown how antibodies, collected from a clinical study volunteer, bind to the SARS-CoV-2 Spike protein to neutralize the virus.
Viruses like influenza A and Ebola invade human cells in a number of steps. In an interdisciplinary approach, research teams from Heidelberg University and Heidelberg University Hospital investigated the final stages of viral penetration using electron tomography and computer simulations.
Little is known about how radiation therapy to kill cancer cells affects immune cells and other components of patient tumors. But a study out of Roswell Park Comprehensive Cancer Center is shedding light on that process, providing information that could be key for planning treatment regimens that combine immunotherapy and radiation therapy. The authors outline their findings in a new study in the Journal for ImmunoTherapy of Cancer.
UC San Diego researchers describe a key player in the defense mechanism that safeguards against excessive insulin in the body, which can be as harmful as too little.
Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.
According to a new Finnish study, greenness around the home in early childhood does not seem to protect children from atopic eczema. Instead, the proximity of coniferous, mixed forests and agricultural areas was associated with elevated risk of eczema. The effect was seen especially in children who were born in the spring.
The risk of developing lymphoma is slightly elevated in inflammatory bowel disease (IBD) and has increased in recent years in patients with Crohn’s disease, report researchers from Karolinska Institutet in a study published in Clinical Gastroenterology and Hepatology.
Researchers at the Icahn School of Medicine at Mount Sinai have demonstrated in a preclinical study a potential new therapeutic approach to treating the most common form of lung cancer. The strategy involves inhibiting the immune-system molecule TREM2 while enhancing natural killer cells (the so-called protectors of the immune system). It was described in the April 20 online issue of Nature Immunology.
UC Davis Health researchers have dosed the second participant in their clinical trial looking to identify a potential cure for HIV utilizing CART-cell therapy.
The Johns Hopkins Malaria Research Institute at the Johns Hopkins Bloomberg School of Public Health will host its annual World Malaria Day Symposium Tuesday, April 25, from 8:30 a.m. to 5:45 p.m. EDT. The theme is the blood stage of malaria, which is the most devastating phase of the disease. The event will take place in person in Baltimore with thirteen panelists. A remote option is available to journalists.
A recent Houston Methodist study may offer some guidance on when certain populations should get their next booster. A research team of computational medicine and data scientists from the Houston Methodist Research Institute predicted the immune response to COVID-19 vaccines with a math model they developed, and also found that current CDC dosing intervals may require customization to protect all individuals alike.
A new study from Huntsman Cancer Institute shows HPV-related cancers are more common in young adults who previously had cancer. This data shows the importance of educating patients about the HPV vaccine – a safe and effective way to prevent cancer.
The immuno-oncology (IO) clinical trial landscape is shifting in new directions. While the number of total clinical trials is down, there are healthy signs of innovation.
The dreaded tick-borne encephalitis (TBE) virus infects different types of brain cells in different parts of the brain, depending on whether the affected person's immune system is activated or not. This is shown in a new study at Umeå University, Sweden.
Indiana University Melvin and Bren Simon Comprehensive Cancer Center served as the lead site for a promising first-in-human clinical trial for patients with relapsed multiple myeloma. Patients treated with higher doses of the immunotherapy called REGN5459 resulted in a 90.5 percent overall response rate.
La Jolla Institute for Immunology (LJI) Instructor Estefania Quesada Masachs, M.D., Ph.D., has won the 2023 Young Investigator of the Year Award from the Network for Pancreatic Organ donors with Diabetes (nPOD). This prestigious award recognizes Quesada Masachs' groundbreaking research in type 1 diabetes.
A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to Phase III trial results presented today by researchers from The University of Texas MD Anderson Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2023.
In November 2022, the National Institute of Allergy and Infectious Diseases (NIAID) co-hosted a virtual workshop on the importance and challenges of developing mucosal vaccines for SARS-COV-2. The highlights of this workshop have now been published as a report in npj Vaccines.
New research led by the UNC Gillings School of Global Public Health shows that bivalent COVID-19 boosters are still providing effective protection from hospitalization and death, even against the most recent omicron subvariants.
Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research. Their new study presents several crucial themes in the biology of pancreatic cancer that can serve as hallmarks for pancreatic cancer therapy.
Houston Methodist nanomedicine researchers have found a way to tame pancreatic cancer - one of the most aggressive and difficult to treat cancers - by delivering immunotherapy directly into the tumor with a device that is smaller than a grain of rice.
The key to understanding allergies may lie in genetic and environmental triggers as well as a person’s lifestyle. A Penn State Health physician discusses what causes seasonal allergies and how to alleviate the symptoms.
Below are some of the latest headlines in the new Avian Flu channel on Newswise.
New smart-drug treatment options for pancreatic cancer, immuno-oncology treatments and real-time immune-monitoring strategies are among the research topics to be presented by investigators at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) at the American Association for Cancer Research (AACR) annual meeting held April 14-19 at the Orange County Convention Center in Orlando, Florida.
James P. Allison, PhD, is the recipient of the 25th Herbert and Maxine Block Memorial Lectureship Award for Distinguished Achievement in Cancer. A 2018 Nobel Prize co-recipient in physiology/medicine, Allison serves as the chair of immunology and executive director of the Immunotherapy Platform at The University of Texas MD Anderson Cancer Center.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the American Association for Cancer Research (AACR) Annual Meeting 2023.
Testing the efficacy of a vaccine candidate is typically a long process, with the immune response of an animal model taking around two months. A multi-institution team is developing a method that is more than an order of magnitude faster.
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Researchers reporting in ACS Central Science have developed a new testing platform that encapsulates B cells — some of the most important components of the immune system — into miniature “organoids” to make vaccine screening quicker and greatly reduce the number of animals needed for testing.
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