A subset of healthcare workers vaccinated against COVID-19 had unexpectedly low responses to the immunizations, according to Cedars-Sinai investigators. The findings of the new study are published in iScience, a Cell Press journal.
Researchers at UC San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs. The discovery opens the possibility of new therapies, including for multiple forms of cancer.
Using a simple set of magnets, MIT researchers have come up with a sophisticated way to monitor muscle movements, which they hope will make it easier for people with amputations to control their prosthetic limbs.
Researchers have found a small molecule enzyme inhibitor capable of manipulating an immune process that plays an important role in cancers and autoimmune diseases.
A new approach to cancer immunotherapy that uses one type of immune cell to kill another—rather than directly attacking the cancer—provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York. The findings were published October 11, 2022 in the journal Cancer Immunology Research [https://doi.org/10.1158/2326-6066.CIR-21-1075]. The study involved a twist on a type of therapy that uses immune cells known as CAR T cells. CAR T cells in current clinical use are engineered to recognize cancer cells directly and have successfully treated several blood cancers. But there have been challenges that prevent their effective use in many solid tumors.
A study of nearly 2,000 children found that those who reported playing video games for three hours per day or more performed better on cognitive skills tests involving impulse control and working memory compared to children who had never played video games.
Dysregulation of macrophages during SARS-CoV-2 infection and the over-exuberant production of pro-inflammatory cytokines by these macrophages has been hypothesized to contribute to severity of COVID-19 disease.
Researchers at Vanderbilt University Medical Center have found that the change in a single letter of the genetic code promotes, in a mouse model, the development of inflammation, high blood pressure and resulting kidney damage.
Today, patients utilizing their Medicare Hospice Benefits with end-stage kidney disease (ESKD) are forced to make the traumatic choice between continuing dialysis or enrolling in hospice.
A new study may prompt medical experts to rethink when to start mammograms for women who have a mother, sister or daughter diagnosed with breast cancer.
A mouse study by Kristin Stanford, a physiology and cell biology researcher with The Ohio State University College of Medicine at the Wexner Medical Center, provides new ways to determine how maternal and paternal exercise improve metabolic health of offspring.
The GW School of Medicine and Health Sciences is recruiting participants for the final stage of a clinical trial to evaluate two Omicron-specific vaccines. The study, known as the COVID-19 Variant Immunologic Landscape (COVAIL) trial, is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). The George Washington University School of Medicine and Health Sciences has received funding support as an agreement under NIH contract number 75N91019D00024 to Leidos Biomedical Research in Frederick, Maryland.
The National Institutes of Health (NIH) has awarded a $1.1 million grant to the University of Maryland Schools of Pharmacy (UMSOP) and Medicine (UMSOM) to create a training program to enhance diversity in the biomedical workforce. The five-year Initiative for Maximizing Student Development (IMSD) program strives to increase the number of students from underrepresented groups in the doctoral programs in the UMSOP’s Department of Pharmaceutical Sciences (PSC) and UMSOM’s Graduate Program In Life Sciences (GPILS).
Investigators from the departments of Neurology, Neurosurgery, Psychiatry, Medicine, and Biomedical Sciences at Cedars-Sinai have shown that an immune-suppressing drug similar to one used to treat severe COVID-19 reversed symptoms of delirium in mice whose lungs were injured during mechanical breathing assistance.
A team led by researchers at Beth Israel Deaconess Medical Center are joining the NIH to develop a framework for mapping the human body cell by cell.
UTSW study suggests combination therapy might help prostate cancer patients overcome resistance to current treatments
NIH’s National Institute of Allergy and Infectious Diseases awarded Texas Biomedical Research Institute and The Access to Advanced Health Institute in Seattle, Washington, a $3.5 million, five-year Innovation for Tuberculosis Vaccine Discovery grant.
The Icahn School of Medicine at Mount Sinai has been awarded a five-year, $55.5 million grant from the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) Program that will benefit the diverse patient population Mount Sinai serves by accelerating the development of new treatments for leading health conditions, including cardiorespiratory and psychiatric disorders, diabetes, malignancies, and infectious diseases.
In a set of identical twins, investigators have discovered a disease that affects the mitochondria, or the specialized compartments within cells that produce energy
Researchers worldwide will need further assistance to help comply with an increasing number of open data mandates, according to the authors of a new report.
A combination of brain imaging data and machine learning can accurately diagnose obstructive sleep apnea (OSA) significantly faster than the standard methods now in use that are complex, costly, time-consuming, and can delay crucial treatment.
In a research paper published in PLOS ONE, The Wistar Institute's Dario C. Altieri, M.D., alongside national and international collaborators, distinguish a specific gene signature indicative of mitochondrial reprogramming in tumors that correlates with poor patient outcome.
The environment could be playing a critical role in the expression of polycystic ovary syndrome (PCOS) in women living in Alabama, as compared to women in California, according to a new study published in the Journal of Clinical Endocrinology & Metabolism.
Women with polycystic ovary syndrome (PCOS) in Alabama may be more likely to have excessive hair growth and insulin resistance, whereas women with PCOS in California may be more likely to have higher testosterone levels, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. The study published in Nature Communications.
National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. The study published in Nature Communications.
Researchers from Johns Hopkins Medicine have discovered that the organization of different types of immune cells within pancreatic tumors is associated with how well patients with pancreatic cancer respond to treatment and how long they survive.
UC San Diego researchers discover that quality and mix of protein in a type of pancreatic cancer is the determinant of whether the prognosis is poor or very poor.
A $500,000 grant from the National Institutes of Health will enable researchers to tackle chronic health disparities through the use of electronic health records (EHR), artificial intelligence, machine learning (AI/ML) and the Internet of Things (IoT).
Researchers at Washington University School of Medicine in St. Louis have identified a pathway in the brains of mice that is activated when the animals see other mice scratching, but that pathway does not run through the visual cortex.
The National Institutes of Health has awarded Amelia Escolano, Ph.D., assistant professor in The Wistar Institute’s Vaccine & Immunotherapy Center, the 2022 NIH Director’s New Innovator Award.
UC San Diego study finds enhanced PKCγ activity drives spinocerebellar ataxia type 14; suggests inhibiting the enzyme may have therapeutic potential
Scientists at La Jolla Institute for Immunology have uncovered an immune cell defect tied to the risk of developing MAC disease (a relative of tuberculosis).
The National Institutes of Health (NIH) has awarded a $15.75 million contract to researchers led by Case Western Reserve and Duke universities to accelerate development of therapeutic devices that improve chronic medical conditions.
Researchers from the Brain Injury Research Center of Mount Sinai have been awarded $8.3 million from the National Institutes of Health (NIH) to investigate the clinical and biological features that distinguish chronic, static effects of traumatic brain injury from those associated with progressive, post-traumatic neurodegeneration.
Researchers at The University of Texas MD Anderson Cancer Center have identified a specific gut bacterium involved in the progression of graft-versus-host disease (GVHD) after antibiotic treatment of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and discovered that nutritional supplementation can prevent antibiotic-induced GVHD in preclinical models, according to a study published today in Cell.
The National Institutes of Health (NIH) awarded a $10.7 million five-year renewal grant to Cleveland Clinic to expand a national research consortium focused on improving the diagnosis and treatments for Dementia with Lewy Bodies. The Dementia with Lewy Bodies Consortium, established in 2017, centralized research efforts and created a national, coordinated registry for clinical data.
A new study focused on the immune system’s Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such as multiple sclerosis.
A new model to predict the life expectancy of older people relies less on their specific disease diagnoses and more on factors such as the ability to grocery shop, the amount of certain small cholesterol particles circulating in their blood, and whether they never or only occasionally smoked.
Sylvester Comprehensive Cancer Center researchers Lluis Morey, Ph.D., and Ramiro Verdun, Ph.D., have received a $1.8 million NIH R01 grant to study the epigenetic mechanisms that drive head and neck cancers.
The National Institutes of Health, through its Blueprint MedTech program, has established two incubator hubs and launched a funding solicitation in support of commercially viable, clinically focused neurotechnology solutions to diagnose and treat disorders of the nervous system.
Fat cells, or adipocytes, that grow in close proximity to breast cancers can shift into other cell types that promote tumor growth, a new study by UT Southwestern researchers suggests. The findings, published in Cell Reports, could lead to new ways to fight breast cancer, a disease that is diagnosed in more than 300,000 U.S. women each year and kills nearly 45,000 annually.
St. Jude scientists have created a tool that can find safe places to put corrected genes into the genome, called safe harbor sites, using genomic and epigenetic information from specific tissue, such as blood cells.
Researchers from Northern Arizona University and the University of Washington School of Medicine in collaboration with the Washington National Primate Research Center received a five-year, $7.5 million grant from the National Institutes of Health to fund a groundbreaking project that they hope will result in a safe and effective vaccine for Valley Fever.
Cleveland Clinic received a $7.9 million five-year grant from the National Cancer Institute at the National Institutes of Health to form one of three national centers as part of the newly established Radiation Oncology-Biology Integration Network (ROBIN).
Irvine, Calif., Sept. 22, 2022 – The University of California, Irvine will participate in a five-year, multi-institutional, $126 million grant from the National Institutes of Health supporting the BRAIN Initiative Cell Atlas Network. The project aims to describe the cells that make up the human brain in unprecedented molecular detail, classifying them into more precise subtypes and pinpointing their location.
Researchers at Albert Einstein College of Medicine have now received a five-year, $3.4 million grant from the National Institutes of Health (NIH) to assess the tradeoffs between soccer’s aerobic brain benefits and the adverse effects from heading in a study employing neuroimaging, exercise testing, and cognitive testing.
A five-year, nearly $5 million grant, which will help create a coordinating unit for biostatistics, informatics, and engagement (CUBIE) for a Cell Atlas Network program to advance knowledge about the interacting neurons of the human brain, has been awarded to researchers at UTHealth Houston by the National Institutes of Health (NIH) Brain Research Through Advancing Neurotechnologies (BRAIN) Initiative.
The research projects, part of the NIH's BRAIN Initiative, aim to shed light on the developing brain’s cellular infrastructure to better understand brain disorders.
With a $126 million grant from the National Institutes of Health, a multi-institution team of researchers at UC San Diego, Salk Institute and elsewhere has launched a new Center for Multiomic Human Brain Cell Atlas to describe human brain cells in unprecedented detail over a lifetime.
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