Researchers at UC San Diego Health have launched a pair of clinical trials to study the immune response of COVID-19 vaccinated transplant recipients of bone marrow and solid organs, such as the heart, lung, liver and kidney.
• In a study of patients waiting for a kidney transplant, those who experienced various symptoms had a higher risk of dying while on the waitlist. • Symptoms tended to increase or remain unchanged between transplant evaluation and transplantation; however, at 3 months after transplantation, 9 of 11 symptoms lessened.
• Among U.S. adults with kidney failure, many of those who have the longest expected post-transplant survival are not being placed on the kidney transplant waiting list. • African Americans, patients lacking commercial health insurance, and those residing in lower income communities are less likely to be waitlisted.
In a study published today in the Annals of Internal Medicine, Johns Hopkins Medicine researchers say they believe that, for the first time, there is evidence to show that three doses of vaccine increase antibody levels against SARS-CoV-2 — the virus that causes COVID 19 — more than the standard two-dose regimen for people who have received solid organ transplants.
Faculty from the McKelvey School of Engineering and the School of Medicine teamed up to design better grafts for dialysis patients.
Treating transplant patients with mild to moderate cases of COVID-19 with monoclonal antibodies is safe and helps prevent serious illness, according to a Mayo Clinic study recently published in Open Forum Infectious Diseases. These results are especially important because transplant patients who are infected with COVID-19 have a higher risk of severe illness and death.
• A large majority of patients with kidney failure on dialysis—but not kidney transplant recipients—developed antibody responses to SARS-CoV-2 after COVID-19 vaccination. • Vaccination also led to strong T cell responses against the virus that causes COVID-19 in all patients on dialysis, and in nearly 58% of kidney transplant recipients.
Irvine, Calif., June 3, 2021 — A multidisciplinary research team led by Jonathan Lakey, Ph.D., professor of surgery and biomedical engineering at the University of California, Irvine, has developed a biomaterial for pancreatic islet transplants that doesn’t trigger the body’s immune response. Based on stem cell technology, hybrid alginate offers a possible long-term treatment for Type 1 diabetes, an autoimmune reaction that destroys pancreatic islets’ beta cells, which regulate blood glucose levels.
• Among patients receiving dialysis in the Southeastern United States, those at for-profit dialysis facilities were less likely to be referred for kidney transplantation than those at non-profit facilities. • Rates of starting medical evaluations soon after referral and placing patients on a waitlist after evaluations were similar between the groups.
In a new study, supported by a five-year, $6.4 million grant from the National Eye Institute of the National Institutes of Health, researchers from Case Western Reserve University, University Hospitals and the Jaeb Center for Health Research, aim to finally determine which diabetic individuals can successfully donate their corneas for keratoplasty (and which should not).
Last month, Lara Holmes celebrated two birthdays—her normal birthday, and the first birthday since she received the gift of a lifetime: a new pancreas and kidney.
Patients with idiopathic pulmonary fibrosis (IPF), a rare lung disease that causes shortness of breath and low oxygen levels because of lung scarring, have worse outcomes if they live in poor neighborhoods, according to research presented at the ATS 2021 International Conference.
A loving & doting daughter saves the live of her mother in desperate need of a kidney transplant as well as the life of a Minnesota woman.
In a study published today in the Journal of the American Medical Association (JAMA), Johns Hopkins Medicine researchers show that although two doses of a vaccine against SARS-CoV-2 — the virus that causes COVID 19 — confers some protection for people who have received solid organ transplants, it’s still not enough to enable them to dispense with masks, physical distancing and other safety measures.
Mother's Day, our annual reminder to honor amazing moms everywhere, is next Sunday, May 9. Cedars-Sinai invites you to learn more about two mothers who went to heroic lengths to deliver their children, and another mother who is inspired by her heroic daughter.
April 8, 2021 – The Division of Rheumatology, Department of Medicine, Faculty of Medicine (CU Medi), Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society (Chulalongkorn Hospital), in collaboration with the Departments of Hematology, Pulmonary and Critical Care Medicine, and Infectious diseases, held a press conference on “Thailand’s first successful treatment of systemic sclerosis patients with pulmonary fibrosis by stem cell transplantation“.
A new study, presented today at the AATS 101st Annual Meeting, found that heart transplantation using donation after cardiac death (DCD) with normothermic regional perfusion (NRP) is feasible in the United States.
New research being presented at the virtual 2021 Annual Meeting of The Association for Research in Vision and Ophthalmology (ARVO) demonstrates that adverse environments is possibly an avoidable risk factor for ocular graft-versus-host-disease (oGVHD), a rapidly progressing, sight-threatening condition of the eye following allogeneic hematopoetic stem cell transplantation (aSCT).
Clinically Viable Blood Test for Donor-Derived Cell-Free DNA Can Vastly Reduce the Need for Routine Surveillance Biopsies Following Heart Transplantation
• A pharmacist-led smartphone health app helped prevent medication errors, medication-related side effects, and hospitalizations in a study of kidney transplant recipients.
To anyone else, it’s just a walk around the block. But for Frank Coburn, 57, and his wife, it’s a miracle. A miracle that resulted from Coburn becoming the first Southern Californian—and possibly first in the U.S.—to receive a minimally invasive double lung transplant. The procedure was performed at the Smidt Heart Institute.
New insights into how fetal and adult liver cells differ could be used to help make liver cell transplants successful long term. Transplanting functioning liver cells into a patient’s liver can help replace liver function that is impaired due to disease.
Thousands of livers donated for transplantation are discarded or turned down every year due to concerns about organ quality and function. New insights into why these organs are considered unusable and how they function during external perfusion could help save lives by greatly increasing the number of livers that are transplantable.
A small study from Mayo Clinic researchers raises the concern that some transplant patients may have a limited immune response after being vaccinated for COVID-19 with an mRNA vaccine. Their findings are published as a letter to the editor in the American Journal of Transplantation.
David Goldberg, M.D., M.S.C.E., associate professor of medicine in the Division of Digestive Health and Liver Diseases at the University of Miami Miller School of Medicine, is one of three principal investigators of a five-year, $7.8 million National Institutes of Health-funded study using donor kidneys infected with hepatitis C (HCV) in patients awaiting kidney transplants who do not have HCV.
n many ways 19-year-old, Brenna Kahlen is a typical teenager. She is living at home in Newport Beach, working and going to college. But unlike most of her peers, Brenna is a now a medical first.
Reporters are invited to join a live Q&A discussion of exciting research announcements at the forefront of the life sciences during a virtual press conference for the Experimental Biology (EB) 2021 meeting. The press conference will be held online from 1–1:45 p.m. EDT on Monday, April 26, 2021 (RSVP by Friday, April 23).
Researchers from University Health Network have developed and validated an innovative deep learning model to predict a patient’s long-term outcome after receiving a liver transplant.
Case done at University Health Network is believed to be a first in Canada on a patient whose lungs were irreparably damaged by COVID-19
Historic case launches Mount Sinai’s Tracheal Transplant Program for treating patients worldwide, including those with severe intubation damage after COVID-19
In May 2020, a team led by thoracic surgeon Konrad Hoetzenecker of the Department of Surgery of MedUni Vienna and Vienna General Hospital performed a lung transplant on a 44-year-old patient who had been seriously ill with Covid-19, making her the first patient in Europe to receive a lung transplant for this indication.
Dominic Emerson, MD, and Pedro Catarino, MD, both transplant surgeons with the Smidt Heart Institute, know how to be spontaneous. At any given moment, they can get the call that a donor heart or lungs are available, requiring them to quickly board a private aircraft to procure the vital organs.
Patients with high levels of antibodies face major challenges getting a transplant. These highly sensitized patients have a higher risk of death while waiting for suitable organs. But there is new hope for highly sensitized patients in need of a combined heart and liver transplant, thanks to an innovative surgical approach at Mayo Clinic.
One year ago, then 65-year-old Miriam Clark developed a fever, lost her appetite and had no energy. She and her daughter, Tye Clark, the administrative services manager of the Johns Hopkins University School of Medicine Division of Hospital Medicine, never could have imagined what they would end up going through before Miriam was diagnosed with COVID-19. Looking back on the year, the mother and daughter duo are thankful and now even have reason to celebrate.
‘Tissue-resident memory T cells’, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection.
New York City's Memorial Sloan Kettering Cancer Center (MSK) announces the following awards and appointments for March 2021.
An RNA molecule, cataloged in scientific databases simply as Linc00402, helps activate immune defenders known as T cells in response to the presence of foreign human cells. Findings suggests inhibiting the RNA therapeutically might improve outcomes for transplant recipients.
قد لا يشعر الأشخاص المصابون بأمراض الكلى المزمنة بالمرض أو يلاحظون الأعراض. لكنها مصدر قلق صحي عالمي، مع عدد وفيات يُقدَّر بنحو 1.1 مليون في جميع أنحاء العالم.
• Patients with kidney failure associated with sickle cell disease benefit from kidney transplants, but they’re less likely than other patients to receive them.
Researchers have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene and prevent permanent damage, potentially using an existing medication.
• Racial disparities in access to kidney transplantation persist in the United States. New research indicates that registering Black patients on the kidney transplant waitlist at a slightly higher level of kidney function compared with white patients might lessen racial inequality in patients’ wait time prior to kidney failure onset, and ultimately improve racial equity in access to kidney transplantation.
Penn State Health Milton S. Hershey Medical Center became the second hospital in the nation to implant a newly-designed mechanical pump in a patient with severe heart failure.
Around 80% of the UK population is currently infected with human cytomegalovirus (HCMV) and in developing countries this can be as high as 95%.
• Veterans who receive all of their post–kidney transplant care within the Veterans Health Administration (VA) have a lower risk of death than those who receive care outside the VA through Medicare coverage, according to a recent study.
Two January 2021 reports show that survival rates for heart transplant and LVAD implant surgeries at Penn State Health Milton S. Hershey Medical Center rank among the nation’s best.
• Despite wide recognition, policy reforms, and extensive research to address barriers in patients’ access to kidney transplantation, investigators found no improvement in rates of wait list placement and transplantation over 2 decades. • Moreover, rates among vulnerable populations are especially low.
In the age of COVID-19, decisions that affect our day-to-day lives are influenced by analyzing numbers and data. For example, the COVID-19 positivity rate (the percentage of people who test positive for the virus out of the total number tested) influence whether or not businesses may open to the public, or, if schools should offer virtual, hybrid or in-class learning. Data are critical for strategizing, planning and implementing the policies and procedures needed to respond to the crisis and keep people safe.
— The American Society of Nephrology (ASN) re- affirms its support for the Organ Procurement Organizations (OPOs) Conditions for Coverage final rule issued on November 20, 2020. The society calls for the Biden-Harris administration to implement this final policy as expediently as possible. By bringing objective and verifiable standards to assess the performance of OPOs, this final rule will increase the number of organs available for transplant and reduce racial inequity in the U.S. transplant system.
• Race and social determinants of health were associated with the likelihood of undergoing kidney transplantation among US adults with kidney failure. • Interventions that target social determinants of health may improve access to kidney transplantation.
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