Feature Channels: Drug Resistance

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New methodology and tools his team developed by phage expert Graham Hatful provides the opportunity to watch in unprecedented detail as a phage attacks a bacterium.

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The word ‘evolution’ may bring to mind dusty dinosaur bones, but it impacts our health every day.

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Scientists at St. Jude Children’s Research Hospital showed an effective method to avoid activating a major cellular detoxification receptor to overcome drug resistance and toxicity.

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The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments include a new understanding of how HPV drives cancer development, a combination therapy to overcome treatment resistance in mantle cell lymphoma, novel insights into memory T cell formation and potential therapeutic strategies for brain cancers, improved survival outcomes for metastatic colorectal cancer, targeting myeloperoxidase to improve immunotherapy responses in melanoma, and preclinical results of a combination therapy that could effectively treat a subset of acute myeloid leukemia.

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A new study shows that a 2018 California bill banning routine antibiotic use in livestock is linked with reduction in some antibiotic-resistant infections

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SHRO Founder Antonio Giordano contributes to a new publication on the use of liquid biopsy to assess the treatment response and find mutations that confer resistance to cancer therapies.

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Below are some of the latest articles that have been added to the Chemistry news channel on Newswise.

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Scientists at the Paul Scherrer Institute PSI have used the Swiss X-ray free-electron laser SwissFEL and the Swiss Light Source SLS to make a film that could give a decisive boost to developing a new type of drug.

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Like the neurons firing in human brains, bacteria use electricity to communicate and respond to environmental cues.

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Antimicrobial resistance represents one of the top 10 global public health threats according to the World Health Organization, and scientists have been scrambling to find new tools to cure the most deadly drug-resistant infections.

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MD Anderson and Federation Bio announced a strategic collaboration to design and manufacture a synthetic microbial consortium with the goal of improving responses in immunotherapy-resistant cancers.

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Kevin Garey, professor of pharmacy practice and translational research at the University of Houston College of Pharmacy is reporting the first well-controlled study to demonstrate that a microbiome therapeutic, SER-109, is associated with significant quality of life improvement in patients with the debilitating recurrent infection and disease caused by Clostridium difficile (or C. diff).

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Malaria is a devastating disease, with 247 million cases and 619,000 deaths reported in 2021 alone.

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In an internationally conducted clinical trial lead by Dana-Farber involving patients with recurrent ovarian cancer that is resistant to platinum therapy, a novel conjugate therapy called mirvetuximab soravtansine resulted in substantially better responses than standard treatments. Mirvetuximab soravtansine was granted accelerated approval by the U.S. Food and Drug Administration (FDA) in November 2022.

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Johns Hopkins Medicine investigators say their research indicates a new combination of drugs is needed to find an effective treatment for TB meningitis due to multidrug-resistant (MDR) strains

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UC San Diego and its collaborating partners have been awarded $10 million from the Howard Hughes Medical Institute to leverage the biomedical promise of viruses known as bacteriophages as new therapeutic agents in the fight against the rising crisis of antibiotic-resistant bacterial infections.

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