• Several factors not included in prior prediction models were important for atherosclerotic cardiovascular disease prediction among patients with chronic kidney disease. • Adding these factors could aid clinicians and patients with decisions related to heart disease prevention.
The Johns Hopkins Health System will no longer use a long-standing clinical standard that factors a patient’s race into kidney function tests.
While balancing the demands of the COVID-19 pandemic, the team at Baylor Scott & White Medical Center – Temple was able to successfully help nearly 200 patients receive a life-changing organ transplant last year. From January through December 2021, 191 abdominal transplant procedures were conducted, a new record for the hospital and a 25% increase from its previous record set in 2017.
• Interviews of adults with chronic kidney disease and their caregivers who had previously been involved in kidney disease–related research identified various factors that supported their involvement or created challenges to participation.
• Among veterans with acute kidney injury (AKI) at some point between 2008 to 2017, 6% died in-hospital and 28% died within 1 year. In contrast, in-hospital and one-year mortality was 0.8% and 14%, respectively, among non-AKI hospitalizations. • In veterans hospitalized with AKI, in-hospital and one-year mortality rates remained stable throughout the study period.
Do you suffer from urinary incontinence – lack of voluntary control over urination? Want to learn about options available to treat the condition? Konstantin Walmsley, M.D., urologist at Mountainside Medical Center, answers questions about good bladder health and the many effective treatment options.
Un estudio de Mayo Clinic recientemente publicado afirma que el mayor riesgo para los receptores de un trasplante renal no es el rechazo del órgano, sino el cáncer, las infecciones y las enfermedades cardíacas.
câncer, infecções e doença cardíaca representam os maiores riscos para as pessoas que recebem um transplante de rim, e não a rejeição do órgão, de acordo com um estudo da Mayo Clinic publicado recentemente.
مدينة روتشستر، ولاية مينيسوتا- يشكل السرطان والعَدوى وأمراض القلب الخطر الأكبر على متلقي زراعة الكلى- وليس رفض الأعضاء - وفقًا لدراسة مايو كلينك المنشورة مؤخرًا، حيث اكتشف الباحثون أن وفاة المتلقي إثر عوامل أخرى غير رفض العضو هي السبب الرئيسي لفقدان الكلى المزروعة. فواحدة فقط من كل 4 حالات لفقدان الكلى المزروعة تكون بسبب رفض العضو.
根据最近发表的一项妙佑医疗国际(Mayo Clinic)研究，对肾移植受者危害最大的是癌症、感染和心脏病，而不是器官排斥。研究人员发现，由于器官排斥以外的因素导致的受者死亡是移植肾丢失的主要原因。只有1/4的移植肾丢失是由器官排斥造成的。
A new study finds the hormone secretin improves both heart and kidney function. Researchers write that this make secretin “an interesting drug candidate for future studies in heart and kidney failure.” The study is published in the American Journal of Physiology-Endocrinology and Metabolism.
People with type 1 diabetes should be screened regularly for obesity and chronic kidney disease, according to a study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
A record-high 346 organ transplants were done at the University of Chicago Medicine in 2021 — up 42% from the previous year and part of a nationwide trend in transplant surgeries.
• At the start of a study of older adults with advanced kidney disease, women had lower average physical and mental health-related quality-of-life scores compared with men. • Over time, however, both physical and mental scores declined approximately twice as fast in men than in women.
Medicare's new merit-based incentive payment system (MIPS) may drive new changes in practice patterns across the specialty of urology, suggests a study in Urology Practice®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
• In an analysis of data from a recent clinical trial, researchers found that removing a race-based adjustment in the estimation of individuals’ kidney function had a small but potentially important impact on the inclusion of participants, with differing effects on Black and non-Black participants. • Removal of the race-based adjustment also influenced inclusion parameters such as participants’ severity of kidney function impairment at baseline as well as their risk of developing cardiovascular- and kidney-related outcomes.
With the pandemic, there has been a rise in the use of virtual appointments for patients seeking health care. A new study by Tufts researchers, however, suggests that for many older and chronically ill patients, telehealth appointments may be most effective when they augment in-person health-care visits rather than fully replace them.
Cancer, infections and heart disease pose the greatest risk to kidney transplant recipients ― not organ rejection ― according to a recently published Mayo Clinic study. Researchers discovered that recipient death due to factors other than organ rejection is the leading cause for transplanted kidney loss. Only 1 in 4 transplanted kidney losses were caused by organ rejection.
A new analysis of national kidney transplant and organ discard data concludes that too many deceased donor organs with acute kidney injury (AKI) may be needlessly going to waste because of a change in the way kidneys are evaluated.
Rising temperatures due to climate change will lead to an increase in cases of kidney stones over the next seven decades, even if measures are put in place to reduce greenhouse gas emissions, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). Based on data from South Carolina, the study found the increase will be steeper if no action is taken, but an uptick will occur even with mitigation actions, costing the state healthcare system approximately $57 million in the latter scenario and $99 million if nothing is done. The findings were published today in Scientific Reports.
With an $8 million grant from the National Institutes of Health (NIH), the next stage of the THINKER project — called THINKER-NEXT — will aim to provide a comprehensive view of the risks and benefits of transplanting HCV-infected kidneys into non-infected patients.
Survey results indicate that there’s a global shortage of dietitians to provide kidney nutrition care, and many patients with kidney disease who need nutritional interventions either do not receive them or receive suboptimal therapy with inadequate monitoring.
Kidney transplants from deceased donors function for a median of 10 to 15 years. New research indicates that when a kidney transplant fails, retransplantation may offer better survival patients compared with undergoing dialysis.
Penn Medicine has been awarded a prestigious seven-year, $14 million grant from the National Institutes of Health (NIH) to promote organ transplantation for patients with end-stage renal disease who are currently on the waitlist for a kidney transplant. The team will launch a clinical trial harnessing synthetic chimeric antigen receptor (CAR) T cells – a form of which was developed at Penn Medicine and became the first personalized cellular therapy for cancer – for use in patients for whom a compatible kidney cannot be found due to pre-existing antibodies against potential donors.
• New research indicates that many kidney transplant recipients may not be adequately protected against emerging SARS-CoV-2 variants with the standard COVID-19 vaccination regimens currently used in the healthy general population.
The anti-cancer effect of the drug may help those with rare, hereditary cancer syndromes avoid surgeries by shrinking tumors via a daily oral dose.
A new review explores the physiology behind and proposed management strategies for body-wide symptoms of the post-acute sequelae of SARS-CoV-2 (PASC), otherwise known as “long COVID.” The review is published ahead of print in the American Journal of Physiology-Cell Physiology.
• Survey results indicate that acute kidney injury (AKI) has significant impacts on individuals’ physical and emotional health, as well as on their work and family life. • Only about half of respondents rated medical team communication about AKI as very/extremely good.
• Video-based telemedicine is used to facilitate care across all stages of chronic kidney disease. • Video-based telemedicine has evolved in recent years to be less reliant on specialized equipment and has allowed patients to receive kidney care in a location of their choice. • Further work is needed on approaches to sustainable integration and minimizing barriers to access.
For most children with renal masses, the standard of care has long been to remove the entire affected kidney—which is the protocol for Wilms tumor, the most common kidney cancer in children. But is it possible for surgeons to perform partial nephrectomies in some patients with renal masses—safely removing the mass, but leaving the child’s kidney in place?Pediatric urologist Andy Chang, MD, Vice Chair of Operations for the Department of Surgery at Children’s Hospital Los Angeles, recently led a study to investigate this question, and he will present the results in December at The Societies for Pediatric Urology Fall Congress in Miami.
Using high-frequency waves, the new treatment pushes smaller stones from the bottom of the kidney toward the ureter. The procedure allows for an office visit instead of surgery.
Funded by a Specialized Program of Research Excellence (SPORE) award from the National Cancer Institute (NCI), the Kidney Cancer Program (KCP) at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center reports the largest and most diverse catalog of kidney cancer tumor models to date.
Results from a Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center showed that treatment with belzutifan, a small-molecule inhibitor of hypoxia-inducible factor (HIF)-2a, achieved strong clinical activity in patients with renal cell carcinomas (RCC) and non-renal cell carcinoma neoplasms associated with von Hippel-Lindau (VHL) disease. The study was published today in the New England Journal of Medicine.
Individuals with kidney failure who were on dialysis had an incomplete and delayed antibody response and a blunted cellular immune response following COVID-19 vaccination, compared with people with normal kidney function.
University of Maryland Medicine, comprised of the University of Maryland Medical System (UMMS) and the University of Maryland School of Medicine (UMSOM) has announced that it will end the use of a long-standing clinical standard that factors a patient’s race into the diagnosis of chronic kidney disease (CKD).
University of Maryland Medicine will end use of a long-standing clinical standard that factors a patient’s race into the diagnosis of chronic kidney disease. The change could increase access to specialty care including transplant for thousands of Black people living with advanced kidney disease.
A Chula research team has developed a screening strip kit to detect the early stage of chronic kidney disease (CKD) that’s easy to use, yields quick results, increasing the chance of being cured for patients, and helping to cut over 10 billion baht of the ever-increasing annual healthcare costs for CKD patients. The CKD screening strip kits are expected to be released early next year.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include discovering a new protein that regulates the DNA damage response, evaluating immunotherapy plus cryoablation to treat metastatic kidney cancer, identifying radiosensitizer targets to improve radiation therapy response, personalizing treatment intensity for acute myeloid leukemia, and identifying T cell features that play a role in response and resistance to cell therapy in leukemia.
A recent study found that advanced kidney disease is associated with death for cerebral palsy patients independent of related factors, such as cancer and cardiovascular conditions.
Two genetic risk variants that are carried by nearly 40 percent of Black individuals may exacerbate the severity of both sepsis and COVID-19, a team of researchers from the University of Pennsylvania’s Perelman School of Medicine have found.
A new, updated risk score can help predict possible contrast-associated acute kidney injury (CA-AKI) among patients undergoing percutaneous coronary intervention (PCI), Mount Sinai researchers report.
Six-month outcomes from the randomized RADIANCE-HTN TRIO Trial comparing endovascular ultrasound renal denervation (RDN) to a sham procedure for treatment-resistant hypertension (HTN) found that the addition of a pharmacologic intervention led to further blood pressure reductions after RDN with a smaller increase in additional medications prescribed and less use of diuretics.
• People who are on dialysis or who have undergone kidney transplantation have immune system–related differences compared with people with normal kidney function, and these differences are further amplified by SARS-CoV-2 infection. • The findings may help explain why these individuals face a higher risk of dying from COVID-19. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• Taking sodium-glucose cotransporter 2 inhibitors was linked with lower risks of developing cardiovascular disease and kidney failure among patients with type 1 diabetes when using prediction models called the Steno Type 1 Risk Engines. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
• Results from a recent clinical trial indicate that the diabetes drug dapagliflozin slows kidney function decline in patients with chronic kidney disease, regardless of whether they have diabetes. • Results from the study will be presented online at ASN Kidney Week 2021 November 4–November 7.
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