Scientists at the National Institutes of Health, and their colleagues, have discovered that a gene called BACH2 may play a central role in the development of diverse allergic and autoimmune diseases, such as multiple sclerosis, asthma, Crohn's disease, celiac disease, and type-1 diabetes.
A multi-national team of researchers has identified genetic markers that predict educational attainment by pooling data from more than 125,000 individuals in the United States, Australia, and 13 western European countries.
Researchers have developed a new gene therapy to thwart a potential influenza pandemic. They demonstrated that a single dose of an adeno-associated virus expressing a broadly neutralizing flu antibody into the noses of animal models gives them complete protection and substantial reductions in flu replication when exposed to lethal strains of H5N1 and H1N1 flu virus. These were isolated from samples associated from historic human pandemics – the infamous 1918 flu pandemic and another from 2009.
In one of the first successful attempts at genetically engineering mosquitoes, HHMI researchers have altered the way the insects respond to odors, including the smell of humans and the insect repellant DEET. The research not only demonstrates that mosquitoes can be genetically altered using the latest research techniques, but paves the way to understanding why the insect is so attracted to humans, and how to block that attraction.
Experimental genetic techniques may one day provide plastic and reconstructive surgeons with an invaluable tool—the ability to promote growth of the patient's own tissues for reconstructive surgery. A review of recent progress toward developing effective gene therapies for use in "regenerative surgery" appears in the June issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Using a novel method of analyzing genetic variations in families, researchers at Johns Hopkins have found that individually harmless genetic variations affecting related biochemical processes may team up to increase the risk of schizophrenia. They say their findings, reported May 28 in Translational Psychiatry, bring some clarity to the murky relationship between genetics and schizophrenia, and may lead to a genetic test that can predict which medications will be effective for individual patients.
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers from the Icahn School of Medicine at Mount Sinai.
Mayo Clinic researchers have used next generation genomic analysis to determine that some of the more aggressive prostate cancer tumors have similar genetic origins, which may help in predicting cancer progression. The findings appear online today in the journal Cancer Research.
Q&A with Dr. Andrea Farkas Patenaude.
A pioneering genomics technique developed at Cornell University to improve corn can now be used to improve the quality of milk and meat, according to research published May 17 in the online journal PLOS ONE.
Johns Hopkins researchers say they have discovered specific chemical alterations in two genes that, when present during pregnancy, reliably predict whether a woman will develop postpartum depression.
A new measure of the heterogeneity – the variety of genetic mutations – of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer.
A University of Iowa researcher and his colleague have conducted a study that reveals important and useful insights into how and why developmental genes often take inputs from two independent “morphogen concentration gradients.”
Scientists at the Texas Biomedical Research Institute in San Antonio have identified four genes in baboons that influence levels of “bad” cholesterol. This discovery could lead to the development of new drugs to reduce the risk of heart disease.
Vanderbilt phylogeneticists examined the reasons why large-scale tree-of-life studies are producing contradictory results and have proposed a suite of novel techniques to resolve the conflicts.
The tiniest bones in the human body – the bones of the middle ear – could provide huge clues about our evolution and the development of modern-day humans, according to a study by a team of researchers that include a Texas A&M University anthropologist.
A new study in Nature Genetics looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today.
The newly sequenced genome of the carnivorous bladderwort contradicts the notion that vast quantities of noncoding 'junk' DNA are crucial for complex life.
While the genes provided by the father arrive at fertilization pre-programmed to the state needed by the embryo, the genes provided by the mother are in a different state and must be reprogrammed to match.
A team led by scientists at The Scripps Research Institute has found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells’ activities. The discovery could lead to a powerful new class of drugs against viral infections, cancers and other diseases.
A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human development.
Scientists have long known that control mechanisms known collectively as “epigenetics” play a critical role in human development, but they did not know precisely how alterations in this extra layer of biochemical instructions in DNA contribute to development.
Wake Forest Baptist research looks at gene expression profiling in breast cancer.
In a groundbreaking move that provides new insight into avian evolution, biology and conservation, researchers at Texas A&M University have successfully sequenced the complete genome of a Scarlet macaw for the first time.
Kennedy Krieger researchers pinpoint genetic cause of rare disease and common birthmark.
Mutations in genes that regulate cellular metabolism found in families with ataxia, dementia and reproductive failure.
A new genomic test for prostate cancer can help predict whether men are more likely to harbor an aggressive form of the disease, according to a new UC San Francisco study. The test, which improves risk assessment when patients are first diagnosed, can also aid in determining which men are suitable for active surveillance – a way of managing the disease without direct treatment.
Two genome-wide association studies and a subsequent meta-analysis have found that certain genetic variations are associated with susceptibility to Helicobacter pylori, a bacteria that is a major cause of gastritis and stomach ulcers and is linked to stomach cancer, findings that may help explain some of the observed variation in individual risk for H pylori infection.
Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.
An international group of investigators, led by researchers at Thomas Jefferson University’s Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells contain abnormally high levels of the pro-growth protein Stat5.
Scientists’ picture of how a gene strongly linked to Alzheimer’s disease harms the brain may have to be revised, researchers at Washington University School of Medicine in St. Louis have found.
University of Washington engineers and NanoFacture, a Bellevue, Wash., company, have created a device that can extract human DNA from fluid samples in a simpler, more efficient and environmentally friendly way than conventional methods.
The tick-borne Lone Star virus has been conclusively identified as part of a family of other tick-borne viruses called bunyaviruses, which often cause fever, respiratory problems and bleeding, according to new research led by scientists at UC San Francisco (UCSF).
Whitehead Institute Founding Member Rudolf Jaenisch has efficiently created mouse models with multiple gene mutations in a matter of weeks. Because the method does not require embryonic stem cells, the approach also could allow any animal to become a model organism.
A new study led by UNC School of Medicine researchers is the first to identify a genetic risk factor for persistent pain after traumatic events such as motor vehicle collision and sexual assault. The study also contributes further evidence that persistent pain after stressful events has a specific biological basis.
A research team led by a Howard Hughes Medical Institute investigator at the University of California, San Francisco has identified a genetic mutation that is strongly associated with a typical form of migraine.
An analysis of endometrial cancers reveals genetic information that should improve diagnosis and guide treatments for women with an aggressive form of the disease.
Scientists at the Oklahoma Medical Research Foundation studying neurons in Caenorhabditis elegans have found a gene, unc-16, that serves as a gatekeeper, restricting the flow of specific membrane-enclosed organelles from the cell body to the axon. Organelles clogging the axon could potentially interfere with neuronal signaling or cause the axon to degenerate, leading to neurodegenerative disorders.
Kansas State University researcher Bikram Gill is part of an international team of researchers that developed a physical map of wheat’s wild ancestor, Aegilops tauschii, commonly called goatgrass. It's the first huge step toward sequencing the wheat genome – a complete look at wheat’s genetic matter. The work, which has been published in the April 22 edition of the Proceedings of the National Academy of Sciences (PNAS), showed among other things, that most resistance genes seem to lie at the ends of chromosomes and can be easily accessed. The findings can lead to breeding of more productive and sustainable wheat varieties.
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
Researchers propose a new investigative roadmap for the field of evolutionary developmental biology to better understand how innovation at the genetic level can lead to ecological adaptations over time. It should help to close a major gap in understanding what drives evolutionary change.
In a pair of papers published in PLOS Genetics, two diverse teams of scientists, both headed by researchers at the University of California, San Diego School of Medicine, describe novel statistical models that more broadly and deeply identify associations between bits of sequenced DNA called single nucleotide polymorphisms or SNPs and say lead to a more complete and accurate understanding of the genetic underpinnings of many diseases and how best to treat them.
Your genetic makeup can help determine how well your body will respond to weight loss efforts aimed at controlling high blood pressure, a new study confirms. The multi-institutional study, led by researchers at The Cardiovascular Institute, part of the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, may help clarify how hypertension develops and progresses in certain individuals and also identify people for whom weight loss programs are most likely to help reduce blood pressure.
Biologists at UC San Diego have identified eight genes never before suspected to play a role in wound healing that are called into action near the areas where wounds occur.
Research Identifies Potential Therapeutic Targets for Late Onset Alzheimer’s Disease (LOAD) By Revealing a Network of Genes Involved in the Inflammatory Response.
Ancient DNA recovered from a series of skeletons in central Germany up to 7500 years old has been used to reconstruct the first detailed genetic history of modern Europe.
Researchers at UT Southwestern Medical Center have identified a specific gene that regulates the heart’s ability to regenerate after injuries.
International researchers led by Chris Amemiya, PhD, Benaroya Research Institute at Virginia Mason, has published “The African coelacanth genome provides insights into tetrapod evolution” as the cover article in the April 18 issue of Nature.
A new UCSF study has found a clear association between certain genes and the development of lymphedema, a painful and chronic condition that often occurs after breast cancer surgery and some other cancer treatments.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right