Overdose mortality among people age 65 and older quadrupled over 20 years, suggesting the need for greater mental health and substance use disorder policies addressed at curbing the trend.
The American Society of Anesthesiologists (ASA) urges the public to help fight the opioid epidemic by learning to recognize and respond to an overdose. This includes understanding how to use naloxone, a life-saving medication approved today for sale over the counter by the U.S. Food and Drug Administration.
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Recordings of media briefings will be posted by 10 a.m. Eastern Time on each day. Watch recorded media briefings at: www.acs.org/ACSSpring2023briefings.
The fruit of the cocklebur plant, which grows worldwide and is often considered a noxious weed, has antioxidant and anti-inflammatory components that could make it useful as a skin protectant, according to new research.
New research has revealed important information about how aspirin works. The new findings could pave the way to safer aspirin alternatives and might also have implications for improving cancer immunotherapies.
Kristin Rojas, M.D., assistant professor of surgical oncology at Sylvester Comprehensive Cancer Center, has been awarded a three-year, $375,000 grant to investigate the role opioids may play in breast cancer.
From septic shock to sticker shock. Keep up with this ever-growing, changing sector. Below are some of the latest stories on healthcare on Newswise.
A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.
In APL Bioengineering, researchers develop a 3D cell culture system to test how inhibiting fibroblast activities can help treat lung cancer. To simulate the tumor microenvironment and mimic real tissues, the team co-cultured lung cancer cells and fibroblasts in a 3D matrix. The researchers then tested the anti-cancer drug cisplatin with and without two anti-fibrotic drugs, nintedanib and pirfenidone. They found that combining the anti-fibrotic drug nintedanib with the anti-cancer drug cisplatin increased the efficacy of the latter.
Naloxone can reverse potentially fatal overdoses, but it’s less effective against powerful fentanyl. To develop alternatives, researchers are looking to a component of marijuana, CBD. They will present their results at ACS Spring 2023.
The American Society of Anesthesiologists (ASA) is extremely pleased that the decision in the lawsuit filed against ASA, the editor-in-chief of Anesthesiology – the official peer-reviewed scientific journal of ASA – and 11 contributing authors by Pacira Biosciences Inc., which was originally dismissed by the United States District Court for the District of New Jersey in 2022, has been affirmed by the United States Court of Appeals for the Third Circuit.
Researchers at Argonne’s Advanced Photon Source have used serial crystallography, a way to make molecular movies, to see in real time the mechanisms involved in an enzyme that confers antibiotic resistance to a certain bacterium.
Needles are an uncomfortable but necessary aspect of vaccination. But today, scientists report steps toward an alternative, relatively painless method that can deliver biological materials to cells by “shooting” them in with air. They will present their results at ACS Spring 2023.
A new study identified a compound that prevents C. diff infection. Researchers are now using this compound to develop new drug candidates that might eventually offer a way to prevent serious C. diff infections.
Corneal transplants can be the last step to returning clear vision to many patients suffering from eye disease. Each year, approximately 80,000 corneal transplantations take place in the U.S. Worldwide, more than 184,000 corneal transplantation surgeries are performed annually.
Receiving medication for opioid use disorders, such as buprenorphine after an overdose, leads to lower mortality risk, according to a Rutgers study.
MitoQ, a mitochondrial antioxidant that is available to the public as a diet supplement, was found in a mouse study to reverse the detrimental effects that HIV and antiretroviral therapy (ART) have on mitochondria in the brain, heart, aorta, lungs, kidney and liver.
Avinash Sahu, PhD, and his team leveraged artificial intelligence, machine learning, and big data to create a novel way to discover multi-function drugs. The approach used cancer research data, biological data, and transfer learning to not only find drugs with specific properties but also to predict patient responses to them.
A new study has found that people with epilepsy have an increased risk of early death and the increased risk varies depending on where they live, the number of medications they take and what other diseases they may have. The study is published in the March 22, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
New research makes the case for why curcumin could help enhance treatment for ovarian cancer.
As an international study involving University of Gothenburg researchers has shown, a decision tool for health professionals has proved capable of halving the use of antibiotics against urinary tract infections while maintaining patient safety.
University of Wyoming researchers’ study of how microscopic creatures called tardigrades survive extreme conditions has led to a major breakthrough that could eventually make life-saving treatments available to people where refrigeration isn’t possible.
In a study at Imperial College London, detailed brain imaging data from 20 healthy volunteers revealed how the potent psychedelic compound, DMT (dimethyltryptamine), alters brain function.
Staphylococcus aureus, Clostridioides difficile, Candida auris, Drug-resistant Shigella. These bacteria not only have difficult names to pronounce, but they are also difficult to fight off. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria. Antimicrobial resistance is an urgent global public health threat.
In early March, Eli Lilly made headlines after announcing a new $35 price cap on insulin for individuals with private insurance. Novo Nordisk and Sanofi made their own price reduction announcements shortly after Eli Lilly’s move.
The combination of two oral medications has shown positive results in people with prostate cancer, whose disease has spread to other parts of the body. Compared with XTANDI plus placebo, the investigatory combination of TALZENNA and XTANDI demonstrated a statistically significant and clinically meaningful improvement in radiographic progression-free survival.
UC San Diego researchers use a DNA designer drug to restore key protein levels in motor neurons, delaying paralysis in a mouse model of ALS.
Ochsner Health is leading the way for precision medicine nationwide by becoming one of the first hospital systems to standardize genomic testing, significantly advancing ways in which care teams can treat cancer patients. This change helps providers determine individualized treatment by understanding how patients will react to certain drugs, thereby lowering risk of adverse side effects, improving patient experience, and bettering patient outcomes.
A large study of women with rheumatoid arthritis has found that those taking oral contraceptives or hormone replacement therapy (HRT) had a greater chance of achieving remission.
UCB, a global biopharmaceutical company, and Aitia, the leader in the application of Causal AI and "Digital Twins" to discover and develop new drugs, today announced an early drug discovery collaboration focused on the discovery and validation of novel drug targets and drug candidates for Huntington's disease.
For some people receiving methadone for treatment of opioid use disorder (OUD), the co-use of opioids and stimulants such as cocaine is an issue. Now, a new study led by Johns Hopkins Medicine researchers found that bupropion, an antidepressant medication also used for smoking cessation, may help people stop using cocaine while in treatment for OUD.
Researchers from The University of Texas MD Anderson Cancer Center showed that inhibiting menin with revumenib, previously known as SNDX-5613, yielded encouraging responses for advanced acute leukemias with KMT2A rearrangements or mutant NPM1. Findings from the Phase I AUGMENT-101 trial were published today in Nature.
A new study by Tufts University researchers found a molecule that could be a target for treatment in patients who have become resistant to traditional anti-seizure drugs
A new computational study in a mouse model finds biological sex and time of day makes a difference in the effectiveness of diuretics—medications commonly prescribed to manage high blood pressure. The study is published ahead of print in the American Journal of Physiology-Renal Physiology.
Up to 50 percent of cancer-signaling proteins once believed to be immune to drug treatments due to a lack of targetable protein regions may actually be treatable, according to a new study from the Perelman School of Medicine at the University of Pennsylvania. The findings, published this month in Nature Communications, suggest there may be new opportunities to treat cancer with new or existing drugs.
Hackensack Meridian Mountainside Medical Center has been recognized as a Silver Level Antimicrobial Stewardship Recognition Program award recipient by the NJDOH.
The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains. In their newly published study, the team found a novel mechanism through which the gene that expresses angiotensin converting enzyme-2 (ACE-2)—the cellular receptor to which SARS-CoV-2 binds so that it can enter and infect the cell—is turned on.
Prenatal exposure to an anti-nausea drug commonly used in the 1960s and 1970s has been shown to increase risk of colorectal cancer in adult offspring, according to a study by researchers at UTHealth Houston.
Opioids are commonly prescribed to patients that are discharged after a total knee and hip arthroplasty. Patients are typically given larger prescriptions of opioids that can result in an excess of the medication in their home after recovery is over.
Stuart Therapeutics, Inc., a clinical-stage ophthalmic biopharmaceutical company focused on developing therapies for the treatment of anterior segment, refractive and posterior segment eye disorders, today announced that it is sponsoring two research poster presentations by researchers at Vanderbilt University and the University of Rochester at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, which will take place from April 23-27, 2023, in New Orleans, Louisiana.
A new class of oral drugs can inhibit a wide range of SARS-CoV-2 variants, researchers report, potentially identifying new antiviral agents providing broad activity against the constantly emerging new strains of the COVID-19 virus
At this year’s American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting, held March 7 to 11 in Las Vegas, Hospital for Special Surgery (HSS) presented new research on a variety of topics in orthopedic surgery, including studies related to minimally invasive surgery, racial disparities, and opioid alternatives for pain management in spine care.
Juvenile dermatomyositis, a rare but often severe and chronic systemic autoimmune disease, includes a large number of patients who are treatment resistant, requiring long term immunosuppressive therapy. A small open-label study published in Arthritis and Rheumatology shows promise using a targeted biologic therapy called abatacept to treat such patients.
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