A $2.5 million federal grant will allow a multidisciplinary team at McGovern Medical School at UTHealth in Houston to provide prevention and treatment information about HIV, AIDS and sexually transmitted diseases to underserved individuals with substance abuse or mental disorders.
Researchers have solved the last unknown protein structure of HIV-1, the retrovirus that can cause AIDS. This will further explain how the virus infects human cells and how progeny viruses are assembled and released from infected cells.
Following studies showing that cocaine influences the transcription and replication of HIV, Mudit Tyagi, PhD, at GW School of Medicine and Health Sciences, will lead a team researching the underlying mechanisms of that influence.
Scientists have developed an agent to “wake up” HIV lying dormant in cells, which causes it to begin replicating so that either the immune system or the virus itself would kill the cell harboring HIV. They call the technique “kick and kill.”
The National Institute on Drug Abuse has awarded $5 million to researchers at UCLA to develop a resource and data center for millions of pieces of research, lab samples, statistics and other data aimed at boosting research into the effects of substance abuse on HIV/AIDS.
Researchers at Thomas Jefferson University studying combinations of drugs against HIV have discovered why certain drugs sometimes act synergistically but sometimes do not.
Southern Illinois University School of Medicine and the University of Chicago Medicine will use a $1.13 million federal grant to study the opioid epidemic affecting the state’s 16 southernmost counties.
Scientists are closer to discovering what makes some individuals better able to clear viral infections than others can, thanks to a new study by researchers at Rutgers Robert Wood Johnson Medical School's Child Health Institute of New Jersey and the University of Chicago.
The health effects of where people live, work, and interact are well documented, as are the value of neighborhood-level structural interventions designed to improve health. But place-based characteristics that contribute to disparities in HIV transmission and disease burden are poorly understood, possibly resulting in less-effective HIV risk reduction interventions and programming.
The University of Illinois at Chicago College of Nursing has received a four-year federal grant to assist HIV-positive prisoners in Indonesia — a southeast Asian country where the number of new infections is increasing rapidly.
An international team of researchers has developed a simple way for healthcare providers to quickly identify and prioritize patients at the greatest risk of death.
The University of Chicago’s Center for Interdisciplinary Inquiry and Innovation (Ci3) in Sexual and Reproductive Health was awarded a grant to increase access to PrEP in drugstore pharmacies in communities with high rates of STI and HIV infection.
For years, medical investigators have tried and failed to develop vaccines for a type of staph bacteria associated with the deadly superbug MRSA. But a new study by Cedars-Sinai investigators shows how staph cells evade the body’s immune system, offering a clearer picture of how a successful vaccine would work.
African-American men who have sex with men (MSM) remain at heightened risk for HIV infection and account for the largest number of African-Americans living with HIV/AIDS. It has long been understood that there is a clear and persistent association between poverty, transactional sex behavior, and HIV risk. A new University of Pennsylvania School of Nursing (Penn Nursing) study has investigated how educational status relates to HIV risk in this population.
Scientists may have found a clue to why people living with HIV have double the likelihood of developing heart disease. The findings, made by researchers at the University of Pittsburgh Center for Vaccine Research and National Institutes of Health, also show that an experimental drug may hold promise as a potential treatment.
GW researcher received a $2 million grant to study the body's natural defenses against HIV in order to drive development of better vaccines and therapies.
The August tip sheet from Fred Hutch includes stories on breast cancer, skin cells as a cancer repair mechanism, an HIV prevention study, air pollution risk and more -- Here are quick summaries for journalists that offer sources and story ideas from Fred Hutch.
When communities face epidemics of drug abuse, a wave of infectious diseases often follows, including hepatitis and HIV. A new federally-funded program in southern West Virginia, led by West Virginia University, will seek to interrupt that cycle.
• Birmingham committed to the “90:90:90” principle, whereby 90 percent of people living with HIV will know their HIV status, 90 percent of those who know their status will be engaged with clinical care and on anti-HIV therapy, and 90 percent of those on treatment will achieve full viral suppression
• Paris Declaration confirms 13th city to commit to being a Fast-Track City in the effort to end the spread of HIV/AIDS
• HIV/AIDS research powerhouse, UAB stands behind commitment of city to end the spread of the disease
The National Institutes of Health (NIH) has awarded researchers at Albert Einstein College of Medicine and Montefiore Health System a five-year, $3.8 million grant for the first long-term study to test whether medical marijuana reduces opioid use among adults with chronic pain, including those with HIV.
According to a new paper published in the scientific journal mBio, an increase in some types of bacteria living under the foreskin can increase a man’s risk of HIV infection by up to 63 percent.
For the first time researchers at the University of North Carolina at Chapel Hill have developed an assay that can measure antigen production and clearance caused by a latency-reversing agent.
"Good morning, doctor, I am here for my gene editing appointment.” In the future, could this be a greeting heard in physician offices around the world? With the introduction of CRISPR technology, genetic material can now be more easily and precisely edited, even creating changes that can subsequently be inherited by offspring.
The reservoirs of long-term HIV infection mean patients must keep taking daily medication for life. But a new discovery could aid the search for new drugs to clear it entirely
Offering HIV testing to people at health checks when they register at a new GP surgery in high-prevalence areas is cost-effective and will save lives, according to a study involving over 86,000 people from 40 GP surgeries
The National Institutes of Health has awarded the University of North Carolina more than $5.6 million to test a therapeutic vaccine for HIV. The study's principal investigator says the goals are to redirect and strengthen the immune response to the virus.
Cancer drug Vorinostat given every 72 hours can awaken sleeping HIV in the body, says researchers at the University of North Carolina at Chapel Hill. However, it does not clear or deplete infection, meaning additional advances will be needed to achieve a cure.
Researchers from the University of Colorado School of Medicine have discovered that a process that protects the body from autoimmune disease also prevents the immune system from generating antibodies that can neutralize the HIV-1 virus. The findings, which will be published July 11 in The Journal of Experimental Medicine, might be considered by scientists trying to develop a vaccine that can stimulate the production of these neutralizing antibodies.
Advancements in antiretroviral therapy (ART) have allowed people living with HIV/AIDS to maintain a quality of life similar to those without HIV infection. Medication adherence is key, however, as non-adherence to ART can lead to poorer HIV suppression, decreased CD4 cell count, and an increased risk for antiretroviral drug resistance. Prior research has shown that alcohol use is common among persons living with HIV/AIDS, and that the rate of current heavy drinking may be almost double that of the general population. This study examined whether “at-risk” alcohol use – defined as more than three drinks per day for women and more than four drinks per day for men – was associated with ART non-adherence among persons living with HIV/AIDS.
St. Jude Children’s Research Hospital discovery of the mechanism of T cell exhaustion will lead to treatments to enhance immunotherapies against cancers and such viruses as HIV
A streamlined and integrated method of tracking medical records called a laboratory health information exchange narrowed the gap in anti-retroviral therapy and viral suppression between HIV-positive blacks and whites.
HIV-positive women with CMV in their urine at the time of labor and delivery are more than five times likelier than HIV-positive women without CMV to transmit HIV to their infants. The research also found that they are nearly 30 times likelier to transmit CMV to their infants.
For decades, HIV has successfully evaded all efforts to create an effective vaccine but researchers at The Scripps Research Institute (TSRI) and the La Jolla Institute for Allergy and Immunology (LJI) are steadily inching closer. Their latest study, published in the current issue of Immunity, demonstrates that optimizing the mode and timing of vaccine delivery is crucial to inducing a protective immune response in a preclinical model.
Understanding and responding to behavioral trends in groups that are at high risk for HIV infection is critical to the development of effective strategies that decrease HIV incidence and improve access to care. New research based on data from the Centers for Disease Control and Prevention’s National HIV Behavioral Surveillance (NHBS) system are presented in a special supplement to JAIDS: Journal of Acquired Immune Deficiency Syndromes. The journal is published by Wolters Kluwer.
A plant found throughout Southeast Asia traditionally used to treat arthritis and rheumatism contains a potent anti-HIV compound more powerful than the drug AZT, according to a new paper published in the Journal of Natural Compounds.
The National Institutes of Health has awarded researchers at Albert Einstein College of Medicine, The Rockefeller University, The City University of New York Graduate School of Public Health and Health Policy (CUNY), a $7.5 million grant for the Center for AIDS Research focused on preventing HIV transmission and ending the AIDS epidemic.
Researchers from Penn Medicine have developed a new urine test, called UrSure, to monitor adherence to pre-exposure prophylaxis (PrEP) in order to help curb the HIV epidemic and prevent high-risk populations from being infected with HIV.
Building on insights from an HIV vaccine regimen in humans that had partial success during a phase 3 clinical trial in Thailand, a Duke-led research team used a more-is-better approach in monkeys that appeared to improve vaccine protection from an HIV-like virus.