The mutation and its functional effects that cause the genetic disorder Singleton-Merten Syndrome (SMS) has been described for the first time, by an international research team. SMS is now recognized as an autoimmune disorder.
St. Jude Children’s Research Hospital scientists have discovered that a protein widely known for suppressing tumor formation also helps prevent autoimmune diseases and other problems by putting the brakes on the immune response. The research was published recently online ahead of print in the scientific journal Nature Immunology.
Researchers have developed a way to measure upper extremity movement in patients with muscular dystrophy using interactive video game technology. Their hope is to expand inclusion criteria for clinical trials to incorporate patients using wheelchairs.
Learning how good bacteria in the gut feast on complex carbohydrates could end your break up with bread.
Enzymes linked to diabetes and obesity appear to play key roles in arthritis and leukemia, potentially opening up new avenues for treating these diverse diseases, according to researchers at Washington University School of Medicine in St. Louis.
Exercise may help people with Parkinson’s disease improve their balance, ability to move around and quality of life, even if it does not reduce their risk of falling, according to a new study published in the December 31, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers at UT Southwestern and Karolinska Institutet in Stockholm, Sweden, found that endogenous retroviruses (ERV) play a critical role in the body’s immune defense against common bacterial and viral pathogens.
A multi-disciplinary research team from the National University of Singapore (NUS) has made a breakthrough discovery of a new type of immune cells that may help in the development of a future treatment for multiple sclerosis (MS).
Fast facts: • In order to distinguish self from other, the immune system processes proteins from inside and outside the body in different ways. • A new study revises understanding of how the process works and sheds light on autoimmune disease.
The Early RA Support and Education program at Hospital for Special Surgery addresses the needs of people with rheumatoid arthritis. After participating in the free program, based on patient-identified outcomes, 90 percent of participants said they could make informed decisions about their RA.
An international team of researchers has identified a protein that turns a person’s immune system against itself in a form of kidney disease called membranous nephropathy (MN). The findings are published online in the New England Journal of Medicine.
Hospital for Special Surgery researchers found that body mass index (BMI) plays a role in rheumatoid arthritis patients’ ability to achieve a sustained remission. Those who were significantly underweight or overweight/obese were the least likely to remain in remission.
More than 50 studies involving researchers from Hospital for Special Surgery in New York City will be presented at the American College of Rheumatology annual meeting in Boston.
A molecule in the blood shows promise as a marker to predict whether individual rheumatoid arthritis patients are likely to benefit from biologic medications or other drugs should be tried, a Mayo Clinic-led study shows. The protein, analyzed in blood tests, may help avoid trial and error with medications, sparing patients treatment delays and unnecessary side effects and expense. The research is among several Mayo Clinic studies presented at the American College of Rheumatology annual meeting in Boston.
Carefully employing a TNF inhibitor dose-reduction strategy can be just as effective at safely treating RA patients as regular dosing methods, while also saving approximately $7,500 per patient annually.
Mortality risk for patients with rheumatoid arthritis is reduced to that of the general population when patients are treated with the aim to meet a low disease activity score, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Secukinumab, an anti-IL-17A monoclonal antibody biologic drug, showed promise as a treatment for patients with active ankylosing spondylitis, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Rheumatologists at Geisinger Health System in Central Pennsylvania have developed a new model of rheumatoid arthritis patient care that is designed to improve quality while reducing costs, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Women with rheumatoid arthritis are at significantly higher risk of all-cause mortality, particularly respiratory causes, compared to women without the disease, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Baseline levels of serum interferon in rheumatoid arthritis patients may help rheumatologists determine who will have a poor response to tumor necrosis factor-alpha inhibitor drugs, and one day help rheumatologists determine the best treatment options for individual RA patients.
Not only does treatment with tumor necrosis factor (TNF) inhibitor biologic drugs not increase the risk of congestive heart failure in people with rheumatoid arthritis, but it may decrease the incidence of this serious cardiovascular disease in these patients, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Better clinical care and compliance might prevent most gout cases that require hospitalization, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
Patients with rheumatic diseases who are treated with denosumab (Prolia®, Xgeva®) either alone, or in combination with either biologic or non-biologic disease-modifying antirheumatic drugs (DMARDs), do not appear to have a significant increased risk of infections.
Women using intrauterine devices (IUDs) may be at increased risk for producing autoantibodies related to the risk of developing rheumatoid arthritis (RA), according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
People with rheumatoid arthritis who are currently taking biologic drugs may be safely vaccinated for the viral infection herpes zoster, according to new research findings presented this week at the American College of Rheumatology Annual Scientific Meeting in Boston.
Hydroxychloroquine (Plaquenil®), especially at the higher standard dose of 400 mg per day, independently decreases the risk of cardiovascular morbidity in people with rheumatoid arthritis, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
People age 30 or over with autoimmune, inflammatory diseases like rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease, may benefit from vaccinations for the viral infection herpes zoster, according to new research findings presented this week at the American College of Rheumatology Annual Meeting in Boston.
The “What Every American Needs to Know About Autoimmune Disease” public forum arrives in Boston on Saturday, November 15th. Registration is $20 and the program will begin at 9:30am ending at 2:30pm. It will be held at Holiday Inn Express located at 69R Boston Street in South Boston.
A study presented at the annual meeting of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) adds more credence to a growing awareness of the high prevalence of vitamin D deficiency in neuromuscular disease.
Myasthenia gravis is a disorder than can be associated with abnormal function outside of skeletal muscle. Two studies presented at the annual meeting of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) demonstrate that there is a significant proportion of myasthenia patients with arrhythmias and co-morbid inflammatory bowel disease (IBD).
Scores of autoimmune diseases afflicting one in 12 Americans — ranging from type 1 diabetes, to multiple sclerosis (MS), to rheumatoid arthritis, to asthma — mysteriously cause the immune system to harm tissues within our own bodies. Now, a new study pinpoints the complex genetic origins for many of these diseases, a discovery that may lead to better diagnosis and ultimately to improved treatments.
A unique mouse model of Graves' disease, an autoimmune disorder that causes hyperthyroidism, and new research findings that may help improve the treatment of Graves' disease will be highlighted.
Doctors at Loyola University Medical Center say Lauren Bank suffered one of the worst lupus attacks they had ever seen. Virtually every organ in her body was under attack. But she made an extraordinary recovery, and now is in remission.
A study by researchers at Hospital for Special Surgery identifies a new cell signaling pathway that contributes to the development and progression of inflammatory bone erosion, which occurs in patients with rheumatoid arthritis. The study was published online in the Journal of Clinical Investigation.
On Sept. 24-25, George Washington University expert Linda Kusner, Ph.D., organized a meeting of myasthenia gravis experts from across the globe at the National Institute of Neurological Disorders and Stroke
• Among patients with an autoimmune disease called ANCA-associated vasculitis, autoantibody increases were linked with an 11-fold increased risk of relapse in patients whose kidneys were affected. • Among patients without kidney involvement, such increases were associated only weakly with relapses.
A team led by researchers at The Rockefeller University and the Icahn School of Medicine at Mount Sinai has explained the function of key immune protein and solved an international medical mystery, according to a letter published this week in the journal Nature.
A new guideline recommends guidance on how doctors should evaluate the full picture in order to determine what genetic tests may best diagnose a person’s subtype of limb-girdle or distal muscular dystrophy.
Researchers have made a fast-acting “vaccine” that can reverse the course of myasthenia gravis, a non-inherited autoimmune form of muscle weakness, in an animal model of the disease.
Patients with Multiple Sclerosis (MS) were able to safely tolerate treatment with cells cultured from human placental tissue, according to a study published today in the journal Multiple Sclerosis and Related Disorders.
Mathematics might be able to reduce the need for invasive biopsies in patients suffering kidney damage related to the autoimmune disease lupus.
Researchers at the University of Illinois at Chicago College of Medicine have shown for the first time how the activation of a receptor provokes the inflammation and bone degradation of rheumatoid arthritis -- and that activation of this one receptor, found on cells in the fluid of arthritic joints, is all that is required.
I am Dr. Suhayl Dhib-Jalbut, President of ACTRIMS, and on behalf of the President of ECTRIMS, Prof. Maria Trojano, it is my pleasure and honor to warmly welcome you to the sixth triennial Joint ACTRIMS-ECTRIMS Meeting - MSBoston2014.
Salk scientists identify how immune cells use two critical receptors to clear dead cells from the body, pointing the way to new autoimmune and cancer therapies.
A team of researchers from Wayne State University and collaborators from Duke University Medical Center recently published a paper in the Journal of Consulting and Clinical Psychology that explores two psychological interventions separately and in combination to determine their effectiveness in offering relief to RA patients.
Lupus and other rheumatologic diseases can initially present as neurological disorders such as headaches and seizures, and thus delay diagnosis for many months. And treatments can cause adverse neurological effects.
Researchers at Columbia University Medical Center have identified the immune cells responsible for destroying hair follicles in people with alopecia areata, a common autoimmune disease that causes hair loss, and have tested an FDA-approved drug that eliminated these immune cells and restored hair growth in a small number of patients. The results appear in today’s online issue of Nature Medicine.
Salk scientists find control signal for immune system that could help treat autoimmune diseases and cancer.
Babies who are born with severe combined immunodeficiency (SCID) can be successfully treated with a transplant of blood-forming stem cells, according to experts led by Memorial Sloan Kettering’s Richard J. O’Reilly, MD.
Parkinson's disease (PD) patients may confront a common but largely unrecognized challenge: the occurrence of impulse control disorders (ICDs) such as compulsive gambling, sexual behavior, eating, or spending. A team of investigators from the Perelman School of Medicine at the University of Pennsylvania and the Parkinson's Disease Research, Education and Clinical Center (PADRECC) at the Philadelphia Veterans Affairs Medical Center conducted a pilot study and found that the opioid antagonist naltrexone may be an effective treatment for diminishing ICD symptoms in PD patients. The results were published in the journal Neurology.
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