For decades, doctors have treated kids with attention-deficit/hyperactivity disorder (ADHD) with methylphenidate, a stimulant drug sold as Ritalin and Concerta, making it one of the most widely prescribed medications aimed at the central nervous system.
The University of California, San Francisco, and Johns Hopkins University today expanded the UCSF-JHU Opioid Industry Documents Archive, adding one million pages of records from Insys Therapeutics—which manufactured and marketed the fentanyl spray Subsys.
Many pathogenic viruses, including herpesviruses, SARS -Cov-2, cytomegalovirus, papillomavirus, virus Nipah and others, use the similar mechanism to join the target cells, which consists in their attachment to heparan sulfate proteoglycan of the cell membrane.
According to a paper published in Chemical Engineering Journal recently, a team from the High Magnetic Field Laboratory (HMFL), Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences, successfully designed a safe and efficient nanotorpedo for the delivery of chemotherapeutic drugs.
People who take cholesterol-lowering drugs called statins may have a lower risk of having a type of stroke called an intracerebral hemorrhage, according to a new study published in the December 7, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. An intracerebral hemorrhage is caused by bleeding in the brain.
Scientists at Dana-Farber Cancer Institute have developed a drug that potently neutralizes SARS-CoV-2, the COVID-19 coronavirus, and is equally effective against the Omicron variant and every other tested variant. The drug is designed in such a way that natural selection to maintain infectiousness of the virus should also maintain the drug’s activity against future variants.
A largescale new study offers a new approach to treating in type 2 diabetes - that puts patients in charge of their own medication.
Christine Strand Bachmann has led a study that includes all Norwegian children born between 1989 and 1998, a total of 488 000 people.
Physician-scientists from Cedars-Sinai Cancer are available for comment on research being presented throughout the San Antonio Breast Cancer Symposium, taking place Dec. 6-10.
A newly discovered technique, reported in the journal Nanoscale, offers a low-cost way to enhance the effectiveness of existing drugs.
While many new medications designed to treat neurologic diseases have hit the market, utilization by patients remains low due to high costs and similar effectiveness to existing drugs, a new study funded by the American Academy of Neurology finds.
Teens with Type 1 diabetes (T1D) who took bromocriptine, a medication used to treat Parkinson’s disease and Type 2 diabetes, had lower blood pressure and less stiff arteries after one month of treatment compared to those who did not take the medicine, according to a small study published today in Hypertension, an American Heart Association journal.
A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine’s Abramson Cancer Center showed.
Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced the risk for hospitalization for any cause in patients with chronic kidney disease (CKD) with and without type 2 diabetes.
By simulating molecular dynamics, scientists from St. Jude Children’s Research Hospital revealed how the selectivity or promiscuity of GPCR coupling relies on the location and duration of intermolecular interactions.
Henry Ford Health Orthopedic researchers looked at steroids as part of a multi-modal pain control regimen and an alternative to using opioids after outpatient knee replacement. The study won the 2022 American Association of Hip and Knee Surgeons Clinical Research Award.
A new trial will test whether a medication that targets gut bacteria can also improve irritability in teenagers with autism spectrum disorder.
Researchers at The Tisch Cancer Institute uncovered inflammatory markers that may predict which COVID-19 patients are more likely to respond to therapies like the anti-cancer drug pacritinib, according to phase 2 trial results published in JAMA Network Open in December.
Scientists have created a much faster way to make certain complex molecules, which are widely used by pharmaceuticals for antibiotics and anti-fungal medicines.
The life expectancy of women is significantly higher than that of men.
Researchers find that the anesthetic and fast-acting antidepressant switches natural patterns of neuronal activity in the cortex of mice
A Phase 2 clinical trial has started of DS-1211 in individuals with Pseudoxanthoma Elasticum (PXE), a rare multisystem genetic disease that causes calcium deposits in soft tissue resulting in considerable morbidity. DS-1211 is a potential first-in-class small molecule developed through a research collaboration between Daiichi Sankyo and Sanford Burnham Prebys.
While it has long been recognized that drugs that block the cancer-promoting activity of estrogen reduce risk of developing new breast cancers, a new computer modeling study led by researchers at Georgetown Lombardi Comprehensive Cancer Center and colleagues showed that these treatments could also reduce the risk of dying from the disease in women who are at high risk.
Experts reviewing the use of a commonly prescribed family of drugs, known as fluoroquinolones, say safety warnings differ internationally
Researchers found that using buprenorphine to treat opioid-use disorder during pregnancy may result in better outcomes for the baby than methadone.
When the U.S. Food and Drug Administration gave controversial accelerated approval to the first Alzheimer’s drug in nearly 20 years, it had a surprising impact on attitudes about research into the disease.
A number of new neurologic medications for diseases like multiple sclerosis (MS), Parkinson’s disease and migraine have received U.S. Food and Drug Administration (FDA) approval over the past decade. However, with most having higher out-of-pocket costs and benefits similar to existing, less expensive drugs, only a small percentage of people with neurologic conditions are being treated with these new drugs, according to a study funded by the American Academy of Neurology and published in the November 30, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A pilot, “look-back” study of information about 106 patients with “wet” age-related macular degeneration (AMD) treated at the Wilmer Eye Institute at Johns Hopkins Medicine has revealed that nearly half of patients treated with aflibercept could safely stop eye injection therapy after one year without further vision loss.
Reported in Nature, UNC School of Medicine scientists used cryogenic electron microscopy to determine the detailed, high-resolution structures of four designer receptors bound to three drug-like but inert compounds, a major advance in chemogenetics research.
Cedars-Sinai Pharmacy experts will present their latest advances in research and care in person at the midyear clinical meeting of the American Society of Health-System Pharmacists (ASHP) in Las Vegas Dec. 4-8, sharing innovations to improve medication safety, availability and effectiveness for hospital patients.
With a new $3 million-plus grant from the National Institutes of Health (NIH), Case Western Reserve University researchers are examining the next level of treatment for Candida auris (C.auris), a multidrug-resistant yeast that causes serious infection and, in some cases, death.
A Michigan State University researcher is part of an international team that found an existing drug may help decrease side effects of cisplatin, a widely used cancer treatment that was discovered at MSU in 1965.
A team of scientists from the National University of Singapore (NUS) has successfully identified the urinary biomarkers of an emerging subclass of synthetic cannabinoids, called OXIZID, to monitor potential abuse.
Irvine, Calif., Nov. 29, 2022 — When the U.S. Food and Drug Administration gave controversial accelerated approval to the first Alzheimer’s drug in nearly 20 years, it had a surprising impact on attitudes about research into the disease. A survey by University of California, Irvine neuroscientists has found news coverage of the FDA’s decision made the public less willing to volunteer for Alzheimer’s pharmaceutical trials.
Findings from a Johns Hopkins Medicine research study published today in JAMA Network Open provide strong evidence that people who are pregnant and have been infected with SARS-CoV-2 (the virus that causes COVID-19) can safely take the antiviral drug Paxlovid to reduce the possibility of severe disease.
Catalina Island, located 22 miles off the coast of Los Angeles, once collected Hollywood royalty, smugglers and silver miners. Now, it collects trash.
The Urology for Social Responsibility seminar will be offered in the T. Denny Sanford Center Medical Education and Telemedicine on the UC San Diego campus from January 14 to 15, 2023.
Jurata Thin Film, a startup focused on stabilizing vaccines at ambient temperature has raised initial investment funds totaling $4.87 million to develop the technology.
UC San Diego researchers identify the PKCα enzyme as a promising therapeutic target in Alzheimer’s disease; a mutation that increases its activity led to biochemical, cellular and cognitive impairments in mice.
A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, Washington State University-led research indicates.
Plastic waste is one of the most significant ecological and economic problems of our time.
An award-winning scheme that saw community pharmacists support patients to understand the benefits of being jabbed against Covid-19 and overcome initial hesitancy proved hugely successful, new research by an expert from Kingston University has shown.
In a recently published Nature Cancer paper, UChicago Medicine researchers have identified the first biomarker - aneuploidy - that predicts response to the radiation therapy and immune checkpoint blockade treatment combination.
Researchers found young people using benzodiazepines for common sleep conditions had an increased risk of overdose during the six months after starting treatment compared with other prescription sleep medications.
Patients who take statins to lower high cholesterol levels often complain of muscle pains, which can lead them to stop taking the highly effective medication and put them at greater risk of heart attack or stroke.
In a new breakthrough to understand more about the mammalian brain, University of Copenhagen researchers have made an incredible discovery.
A single drug compound simultaneously attacks hard-to-treat prostate cancer on several fronts, according to a new study in mice and human cells.
The COVID-19 pandemic has led to an explosion of clinical research resulting in the development of a variety of vaccines and treatments, although the efficacy of some remains controversial.
Collaborative research between SMU nanorobotics authority MinJun Kim’s Biological Actuation, Sensing, and Transport (BAST) Lab and international research and engineering company ARA has demonstrated for the first time that certain chemical coatings, applied to micro/nanoparticles, can alter their swimming propulsion within biological fluids.
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