An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers at Duke Health report.
Hosted by Chulalongkorn University the APRU APEC University Leaders' Forum 2022 is the first post-pandemic in-person APEC meeting held to foster high-level dialogue between CEOs, policy leaders, university presidents, and top researchers. This event begins Nov 15 at 9 PM EST.
A scalpel-free, high-tech form of brain surgery pioneered at UVA Health offers long-term relief for patients with essential tremor, a common movement disorder, a five-year review shows.
Every day, one person in Switzerland is diagnosed with multiple sclerosis. MS is an autoimmune disease in which the body’s own immune system attacks the myelin sheath of the nerve cells in the brain and spinal cord.
For the first time, scientists have used CRISPR technology to insert genes that allow immune cells to focus their attack on cancer cells, potentially leaving normal cells unharmed and increasing the effectiveness of immunotherapy.
Research shows that incidences of Kaposi’s sarcoma among people living with HIV have fallen significantly over the past two decades, but a new evaluation of data led by researchers at UTHealth Houston highlights a significant disparity among one particular demographic – young Black men in the American South.
A team of researchers at The University of Texas MD Anderson Center has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy. The preclinical findings suggest this adaptable immune conversion approach has the potential for broad application across many cancer types.
Rejuvenating the immune cells that live in tissues surrounding the brain improves fluid flow and waste clearance from the brain — and may help treat or even prevent neurodegenerative diseases such as Alzheimer’s and Parkinson’s, according to a study by researchers at Washington University School of Medicine in St. Louis.
This special edition features upcoming presentations by MD Anderson researchers at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting, including immunotherapy advances in human papillomavirus (HPV)-positive head and neck cancers, microbiome signatures linked with specialized immune-cell clusters, and promising early activity from novel immunotherapy drugs in advanced melanoma and colorectal cancer.
New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, showed that a higher dose of pneumococcal vaccine safely and effectively improved antibody response in patients receiving rituximab for ANCA-associated vasculitis.
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, showed that discontinuing methotrexate for 1 week after seasonal influenza vaccination provided the same seroprotection as a 2 week discontinuation period in patients with RA.
Some cancer cells can deploy parallel mechanisms to evade the immune system’s defences as well as resist immunotherapy treatment, according to a new study from the Garvan Institute of Medical Research.
RUDN scientists have shown the possibility of treating endometriosis with the help of macrophages - immune cells that help fight foreign agents. A new approach in the future can replace the standard treatment with surgery.
Scientists from Trinity College Dublin have unearthed a secret that may explain why some people are able to resist viral infections, having screened the immune systems of women exposed to hepatitis C (HCV) through contaminated anti-D transfusions given over 40 years ago in Ireland.
Mount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the blood cancer multiple myeloma who try an immunotherapy known as CAR-T only to find their cancer coming back afterwards.
Insulin injections to treat Type 1 diabetes could become a thing of the past, but finding the cure faces many challenges. Although transplanting insulin-producing cells represents a promising approach, this cell therapy requires immunosuppression to prevent rejection. Georgia Tech researchers have developed a new biomaterial called iTOL-100 that could cure Type 1 diabetes by inducing immune acceptance of curative transplanted cells without immunosuppression.
As researchers glean new insights into the dynamic inner world of the human immune system, it has become increasingly clear that mitochondria are critical regulators of how our bodies respond to disease.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts.
Patients with cancer and a weakened immune system who are treated with immunotherapies tend to fare far worse from COVID-19 than those who haven't received such therapies in the three months before their COVID diagnosis, show findings in a new study by researchers at Dana-Farber Cancer Institute, and across the U.S., Canada, and Mexico. Researchers found worse outcomes in both the disease itself as well as the fierce immune response that sometimes accompanies it.
A combination of two types of cancer-fighting treatments – the immunotherapy agent pembrolizumab and a nanoparticle-bound form of the chemotherapy drug paclitaxel – may provide an urgently needed new treatment approach for patients who do not respond to or can't receive standard chemotherapy for advanced urothelial cancers, reports a preliminary study in The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Inflammation and increased mucus production are typical symptoms of worm infections and allergies. This immune response involves our innate immune cells, but their exact functions are not yet fully understood.
A new model for understanding which patients with sepsis, Covid-19 and influenza have immune dysfunction and are more likely to suffer poor outcomes has been developed by researchers at the Wellcome Sanger Institute, the University of Oxford, Queen Mary University, Imperial College and their collaborators.
The Flow Cytometry Core at Sanford Burnham Prebys is getting a new piece of state-of-the-art research equipment, thanks to a grant from the National Institutes of Health.
A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center and the University of California San Francisco (UCSF) has discovered the underlying cause of gender differences in immunotherapy-associated myocarditis after immune checkpoint inhibitor (ICI) treatment. Their findings point to possible treatment strategies for this side effect, which disproportionately affects female patients.
In the past several years, myocarditis has been of public interest because of cases associated with vaccines for SARS-CoV2 or related conditions. Another form of myocarditis has been linked to immune checkpoint inhibitors (ICIs) used in cancer care. ICI-induced myocarditis is a potentially fatal side effect of ICI usage, and it appears that the adverse cardiac effects may disproportionally impact female patients. This finding is in contrast to other forms of myocarditis, with more cases reported in male patients.
Nas seis décadas em que o transplante de sangue e medula tem sido usado para tratar pacientes com câncer no sangue, esse tratamento experimental tornou-se uma ferramenta vital de combate ao câncer. A Mayo Clinic, em Rochester, Minnesota, está celebrando a marca de 10 mil transplantes sanguíneos e de medula usados para o tratamento de cânceres sanguíneos e de doenças relacionadas.
مدينة روتشستر، ولاية مينيسوتا. - على مدار الستة عقود الماضية منذ بداية استخدام عمليات زراعة الدم والنخاع لعلاج المرضى المصابين بسرطان الدم، أصبح هذا العلاج التجريبي أداة حيوية لمكافحة السرطان. تحتفل مايو كلينك في مدينة روتشستر بولاية مينيسوتا بإجراء 10,000 عملية زراعة دم ونخاع لعلاج سرطانات الدم والاضطرابات ذات الصلة.
En las seis décadas posteriores a que se comience a utilizar el trasplante de médula para tratar a pacientes con distintos tipos de cáncer de la sangre, este tratamiento, que en un principio fue experimental, se ha vuelto una herramienta vital para la lucha contra el cáncer. Mayo Clinic de Rochester (Minnesota) celebra el trasplante de sangre y médula ósea número 10 000 utilizado en el tratamiento de distintos tipos de cáncer de la sangre y trastornos relacionados.
Cancer immunotherapies, such as immune checkpoint inhibition therapy, have been attracting attention in recent years as new methods for treating cancer.
The Breast Cancer Research Foundation (BCRF) has renewed its funding to Elisa Port, MD, and Hanna Irie, MD, PhD, to study new therapeutic approaches that target aggressive triple-negative breast cancer. The latest installment of $225,000 brings the total to almost $2 million over the past nine years. It will fund research into the immune microenvironment of triple-negative breast cancer in order to identify new strategies to enhance cancer-fighting immune responses for this aggressive breast cancer, which traditionally has few options for treatment.
The American Association of Immunologists, a FASEB member society, supports the career development of young scientists by providing eligible principal investigators with one year of salary support for a trainee in their labs.
Research scientist Bobby Brooke Herrera, renowned for developing tools to accelerate diagnosis and treatment of infectious diseases such as COVID-19, has joined Rutgers Global Health Institute.
Keeping your child safe and healthy is a multifaceted priority for families, starting with the ride home from the hospital in a properly installed car seat.
A Yale-designed nasal vaccine can help bolster immune responses to COVID-19 in previously vaccinated animals and reduce viral transmission, Yale researchers report Oct. 27 in the journal Science.
Viral DNA in human genomes, embedded there from ancient infections, serve as antivirals that protect human cells against certain present-day viruses, according to new research.
The University of Texas MD Anderson Cancer Center today announced that the Timken Foundation of Canton, Ohio, has made a $5 million commitment to support the James P. Allison Institute at MD Anderson. The gift will support the recruitment of top minds from around the world to help realize the Allison Institute’s goals. By establishing a diverse and inclusive environment of scientists from many fields, the Allison Institute will drive exceptional research that integrates immunobiology across disciplines to develop a comprehensive understanding of the immune system.
Two new studies from Washington University School of Medicine in St. Louis support development of a broadly applicable treatment for neurodegenerative diseases that targets a molecule that serves as the central executioner in the death of axons, the wiring of the nervous system.
A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.
Cecilia Lindestam Arlehamn, Ph.D., aims to shed light on how sex-based immune system differences may affect the development and progression of these neurodegenerative diseases in men versus women.
UW Medicine researchers compared vaginal samples collected from 95 young women or adolescent study participants in Kenya before or after they began having sexual intercourse. They found a sharp increase in proteins that control the immune response, including IL-1β, IL-2, and CXCL8, during the first year after becoming sexually active.
A new study from the Centers for Disease Control and Prevention’s VISION Network presents and analyzes some of the first real-world data on mRNA COVID vaccine effectiveness during Omicron BA.4 and BA.5 predominance for immunocompromised adults.
The Global Virus Network (GVN), representing 68 Centers of Excellence and 11 Affiliates in 39 countries comprising foremost experts in every class of virus causing disease in humans, and the Mahidol University in Thailand announced the addition of the Mahidol Virus Network as GVN’s newest Center of Excellence.