Feature Channels: Bone Health

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Argonne’s storied Advanced Photon Source (APS), home to thousands of experiments through the years, is currently aiding in a study of shark spines — one that could shed light on human bones. Stuart R. Stock, a materials scientist and faculty member of Northwestern University’s Feinberg School of Medicine, is using the APS to better understand shark vertebrae’s formation and strength through high resolution, 3D X-ray imaging.

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A new study suggests vitamin D may reverse impaired cell interactions in the blood vessels that occur in preeclampsia—a pregnancy complication characterized by high blood pressure. The finding is published ahead of print in the American Journal of Physiology—Cell Physiology.

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Merging engineering and medical education, a team is providing surgeons-in-training with more realistic and accurate orthopedic surgery simulations through 3D printing and visualized performance data.

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A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

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Vitamin D deficiency from birth to early childhood was associated with an increased risk of elevated blood pressure in later childhood and adolescence

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More than 50 million U.S. adults have arthritis. Many experience severe joint pain and, likely because of their pain, don’t do much exercising if at all.

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People with chronic diseases like arthritis, diabetes and heart disease may one day forego the daily regimen of pills and, instead, receive a scheduled dosage of medication through a grape-sized implant that is remotely controlled.

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Women exposed to triclosan are more likely to develop osteoporosis, according to a study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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Surgery prompted by automobile accidents, combat wounds, cancer treatment and other conditions can lead to bone infections that are difficult to treat and can delay healing until they are resolved. Now, researchers have a developed a double-duty hydrogel that both attacks the bacteria and encourages bone regrowth with a single application containing two active components.

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Every year, nearly 700,000 Americans have surgery for groin hernias.

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Researchers at Johns Hopkins Medicine, the Murdoch Children’s Research Institute in Australia and seven other medical institutions report that an experimental drug called vosoritide, which interferes with certain proteins that block bone growth, allowed the average annual growth rate to increase in a study of 35 children and teenagers with achondroplasia, a form of dwarfism. The patients’ average boost in height to about 6 centimeters (2.4 inches) per year is close to growth rates among children of average stature, and the side effects of the drug were mostly mild, according to the researchers.

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The vitamin D metabolite calcitriol and its analog calcipotriol can block one of the mechanisms through which cancer cells gain resistance to chemotherapy drugs—and can selectively kill those drug-resistant cells.

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Issues like age or existing arthritis may preclude patients from participating in clinical studies for new therapies that could benefit them

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NYU Langone performs first U.S. procedure using newly approved device to reduce risk of repeat surgeries for herniated disc

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Infants who are given antacids in their first year of life are more likely to fracture a bone later as a child, according to a new study published June 7 in Pediatrics.

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Three different types of tendon grafts all provide good long-term outcomes in patients undergoing reconstruction of the anterior cruciate ligament (ACL) of the knee, reports a study in the June 5, 2019 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

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To treat large gaps in long bones, like the femur, that often eventually result in amputation, researchers developed a process that partially recreates the bone growth process that occurs before birth.

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Researchers at the University of Illinois at Chicago and the University of Pennsylvania have developed a unique technique that uses stem cells and flexible implantable bone-stabilizing plates to help speed the healing of large breaks or defects. The technique allows the stem cells applied to break sites to experience some mechanical stress, as they do in developing embryos.

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The debate over how one of the most popular osteoarthritis treatments should be federally regulated could change, thanks to a Cornell University study and a new device that provides a better understanding of the science behind hyaluronic acid (HA) injections.

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A team at Washington University School of Medicine in St. Louis has snapped high-resolution pictures of chikungunya virus latched onto a protein found on the surface of cells in the joints. The structures, published May 9 in the journal Cell, shows in atomic-level detail how the virus and cell-surface protein fit together – data that promises to accelerate efforts to design drugs and vaccines to prevent or treat arthritis caused by chikungunya or related viruses.

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根据Mayo Clinic的新研究，诊断为类风湿性关节炎的患者在确诊疾病前一两年内就会受到功能性残疾的影响。

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Cell therapies including so-called "stem cells" are increasingly being marketed and used for the treatment of musculoskeletal disorders – despite questions about these treatments and their effectiveness. A new tool for standardizing communication about cell therapies is presented in the May 15 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

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Defects of the skull and facial bones can pose difficult challenges for plastic and reconstructive surgeons. A synthetic material called hyperelastic bone – readily produced by 3D-printing – could offer a powerful new tool for use in reconstructing skull defects, reports a study in the May issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

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The American College of Sports Medicine (ACSM) published a collection of 14 new pronouncements that present the science behind the updated Physical Activity Guidelines released in November 2018. Authored primarily by ACSM subject matter experts, each pronouncement addresses a specific topic, sharing the scientific evidence and identifying key knowledge gaps for future research to address.

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Pacientes diagnosticados com artrite reumatoide são frequentemente afetados por uma incapacidade funcional um a dois anos antes do diagnóstico da doença, de acordo com a nova pesquisa da Mayo Clinic.

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Los pacientes con artritis reumatoide generalmente se ven afectados por discapacidades funcionales entre uno y dos años antes de diagnosticar la enfermedad, dice un nuevo estudio de Mayo Clinic.

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A subpopulation of bone cells releases factors that can halt the growth of breast cancer that’s traveled to the bone, putting the cells in stasis.

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HSS Scientists Publish Two Studies On RA Treatment Strategies

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UCLA researchers are co-leading a new pre-clinical study that could prevent patients treated for cancer or osteoporosis from experiencing jawbone damage as a result of oral surgery.

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Patients diagnosed with rheumatoid arthritis often are affected by functional disability a year or two before the disease is diagnosed, according to new Mayo Clinic research.

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Today, the American College of Rheumatology (ACR), in partnership with the Arthritis Foundation (AF), released two guidelines on juvenile idiopathic arthritis (JIA). One guideline aims to provide therapeutic approaches for non-systemic polyarthritis, sacroilitis and enthesitis; and the other focuses on the screening, monitoring and treatment of JIA with associated uveitis.

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The AMSSM Collaborative Research Network (CRN) announced a $300,000 request for proposals addressing knowledge gaps in the management of osteoarthritis (OA) using cooled radiofrequency (CRF) ablation techniques.

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John Giurini, DPM, Chief of Podiatric Surgery at BIDMC, encourages patients to pay special attention to their feet as the weather warms up and they become more active.

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Scientists have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis.

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For patients undergoing arthroscopic surgery to repair a torn rotator cuff, previous steroid injections into the shoulder don't increase the risk of surgical-site infection – unless the injection is administered within one month before surgery, reports a study in the April 17, 2019 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

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Through partnerships with Sanofi Argentina, Sanofi Chile, Sanofi Colombia, Sanofi Pacific and Caribbean, Sanofi Peru and Sanofi Uruguay, the Endocrine Society hosted its first Latin American (LATAM) Leadership Academy. Sixty-two clinicians from over 15 countries across South America, Central America and the Caribbean took part in a one-day leadership training program and attended ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La.

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GRAND RAPIDS, Mich. (April 11, 2019) — An international team of scientists has mapped a molecular complex that could aid in the development of better medications with fewer side effects for osteoporosis and cancer.

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If you're looking for health and fitness story ideas, here is research from the October 2018 issue of Medicine & Science in Sports & Exercise, ACSM’s flagship journal. ACSM is the largest sports medicine and exercise science organization in the world.

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Morristown Medical Center Pediatric Orthopedic Surgeon Finds Obtaining Vitamin D Levels in Children with Fractures Improves Compliance

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Results of a small clinical trial suggest that supplementing chemotherapy with high doses of vitamin D may benefit patients with metastatic colorectal cancer by delaying progression of the disease, say scientists from Dana-Farber Cancer Institute.

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Nationally renowned hematology experts will lead the Multiple Myeloma Program at NYU Langone’s Center for Blood Cancers.

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A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease. The findings point to a pathway to possible treatments for this disease and better understanding of other neurodegenerative disorders, including Alzheimer's disease, that affect millions.

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Researchers learn what makes tendons fray in old age, knowledge that could help develop better treatments for tendinosis and regrow damaged tissue.

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Do you need to wear a sling after surgery to repair a torn rotator cuff? In a new study, not wearing a sling – and engaging in early motion of the shoulder after surgery – leads to faster recovery and better six-month outcomes, reports the March 20, 2019 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

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In collaboration with physicians and researchers at NYU Langone Health’s Center for Arthritis and Autoimmunity, Dr. Yamen Homsi will help patients manage a variety of rheumatologic conditions, including rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, osteoporosis, osteoarthritis, vasculitis, and Behcet’s syndrome.

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A Connecticut man sustained an injury that caused two herniated discs in his spine and resulted in extreme pain and loss of function in his left leg. After successful spine surgery at #DanburyHospital, he’s back to the activities he loves, including prepping his boat for the spring.

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The benefits of treating osteoporosis in postmenopausal women outweigh the perceived risks, according to a Clinical Practice Guideline issued today by the Endocrine Society. The Society introduced the guideline during a news conference on Monday at ENDO 2019, its annual meeting in New Orleans, La.

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Burosumab, a new injectable medicine to treat X-linked hypophosphatemia (XLH), an inherited form of rickets, demonstrates superior improvements in rickets and other outcomes compared with conventional therapy in an international, phase 3 clinical trial in children. Results from what investigators called the first head-to-head study comparing the new drug with conventional treatment for this rare disease will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Exposure to dim light at night, which is common in today’s lifestyle, may contribute to the spread of breast cancer to the bones, researchers have shown for the first time in an animal study. Results of the study will be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.