Feature Channels: Biotech

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Released: 16-Aug-2022 12:00 PM EDT
Fludarabine/TBI 8 Gy versus fludarabine/treosulfan conditioning in patients with AML in first complete remission: A Study from the Acute Leukemia Working Party of the EBMT
Preprints

Gesine Bug, Myriam Labopin, Riitta Niittyvuopio, Matthias Stelljes, Christian Reinhardt, Inken Hilgendorf, Nicolaus Kroeger, Ain Kaare, Wolfgang Bethge, Kerstin Schaefer-Eckart, Mareike Verbeek, Stephan Mielke, Kristina Carlson, Ali

Released: 16-Aug-2022 12:00 PM EDT
Bone Regeneration by Hydroxyapatite-Gelatinnanocomposites
Preprints

Sahar I Mostafa, Nesma M Abdelfattah, Sayed M Ghorab, Manal F Osman, Noha A Elwassefy

Released: 16-Aug-2022 12:00 PM EDT
Mass spectrometry imaging reveals early metabolic priming of cell lineage in differentiating human induced pluripotent stem cells
Preprints

Arina A. Nikitina, Alexandria Van Grouw, Tanya Roysam, Danning Huang, Facundo M. Fernandez, Melissa L. Kemp

Released: 15-Aug-2022 3:05 PM EDT
Scientists develop gel made from spider silk proteins for biomedical applications
Karolinska Institute

Researchers at Karolinska Institutet in Sweden and the Swedish University of Agricultural Sciences have discovered that spider silk proteins can be fused to biologically active proteins and be converted into a gel at body temperature.

Newswise: New Chip Could Make Treating Metastatic Cancer Easier and Faster
Released: 15-Aug-2022 2:55 PM EDT
New Chip Could Make Treating Metastatic Cancer Easier and Faster
Georgia Institute of Technology

Researchers at the Georgia Institute of Technology have found a detection method that could revolutionize cancer treatment by showing how cancers metastasize and what stage they are.

   
Released: 15-Aug-2022 12:00 PM EDT
Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
Preprints

The successful generation of endodermal, ectodermal, and most mesodermal lineages from pluripotent stem cells has resulted in basic discoveries and regenerative medicine clinical trials of cell-based therapies.

Released: 15-Aug-2022 12:00 PM EDT
Alcam-a and Pdgfr-α are essential for the development of sclerotome derived stromal cells that support hematopoiesis in vivo.
Preprints

: Mesenchymal stromal cells are essential components of hematopoietic stem and progenitor cell (HSPC) niches, regulating HSPC proliferation and fate decisions.

Released: 15-Aug-2022 12:00 PM EDT
Mechanical force sensing drives extrusion of Enterovirus A71-infected cells from colonic epithelial organoids
Preprints

Jasmine Moshiri, Ailsa Craven, Sara Mixon, Manuel Amieva, Karla Kirkegaard

Released: 15-Aug-2022 12:00 PM EDT
Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/Syk signaling pathway
Preprints

Guoqiang Yang, Jiraporn Kantapan, Maryam Mazhar, Xue Bai, Yuanxia Zou, Honglian Wang, Bingfeng Huang, Sijing Yang, Nathupakorn Dechsupa, Li Wang

Released: 15-Aug-2022 12:00 PM EDT
Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells
Preprints

Liangwen Zhong, Miriam Gordillo, Xingyi Wang, Yiren Qin, Yuanyuan Huang, Alexey Soshnev, Ritu Kumar, Gouri Nanjangud, Daylon James, C. David Allis, Todd Evans, Bryce Carey, Duancheng Wen

Released: 15-Aug-2022 10:05 AM EDT
Mayo Clinic announces a strategic collaboration for a new era of biomanufacturing
Mayo Clinic

Mayo Clinic today announced a strategic collaboration in biomanufacturing to deliver novel biotherapeutics for rare and complex conditions. The collaboration brings together science, engineering and manufacturing to advance Mayo Clinic's vision of bringing new cures to clinical care. The focus will be on therapies derived from human sources known as biologics — cells, blood, enzymes, tissues, genes or genetically engineered cells — for use in medicines. Therapeutics based on biologics have the potential to target exact tissues needing repair.

Released: 12-Aug-2022 1:05 PM EDT
Smart contact lenses for cancer diagnostics and screening
Terasaki Institute for Biomedical Innovation

Scientists from the Terasaki Institute for Biomedical Innovation (TIBI) have developed a contact lens that can capture and detect exosomes, nanometer-sized vesicles found in bodily secretions which have the potential for being diagnostic cancer biomarkers.

Released: 12-Aug-2022 12:00 PM EDT
Effect of human breast milk-derived exosomes on the migration and inflammatory response of lipopolysaccharide-exposed dental pulp stem cells
Preprints

Ehsaneh Azaryan, Samira Karbasi, Mansoore Saharkhiz, Mohammad Yahya Hanafi-Bojd, Asghar Zarban, Fariba Emadian Razavi, Mohsen Naseri

Released: 12-Aug-2022 12:00 PM EDT
Peripherally Inserted Central Venous Catheter for Pediatric Hematologic Diseases; A Retrospective 11-year Single-center Experience.
Preprints

Silvio Ligia, Salvatore Giacomo Morano, Francesca Kaiser, Alessandra Micozzi, Maria Luisa Moleti, Walter Barberi, Fiorina Giona, Antonio Chistolini, Valentina Arena, Alfonso Piciocchi, Maurizio Forgione, Giulia Gasperini, Marco Fabbri, Anna Maria Testi

Newswise: Safer imaging technology for complex aortic repairs uses light instead of X-rays
Released: 12-Aug-2022 11:05 AM EDT
Safer imaging technology for complex aortic repairs uses light instead of X-rays
UT Southwestern Medical Center

A new imaging device at UT Southwestern is making complex aortic repairs safer for patients and operating room staff by dramatically reducing their exposure to radiation. The device, known as Fiber Optic RealShape (FORS) and manufactured by Philips, uses light to visualize blood vessels, nearly eliminating the need for X-rays typically used during minimally invasive vascular procedures.

Newswise: Two Monumental Milestones Achieved in CT Imaging
Released: 12-Aug-2022 10:05 AM EDT
Two Monumental Milestones Achieved in CT Imaging
National Institute of Biomedical Imaging and Bioengineering

Two biomedical imaging technologies developed with support from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have been cleared for clinical use by the Food and Drug Administration (FDA). Both technologies offer advances in computed tomography (CT).

   
Newswise: Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
Released: 12-Aug-2022 9:50 AM EDT
Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
Mount Sinai Health System

Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

Released: 11-Aug-2022 5:05 PM EDT
Creating an 'adult-like' mature human cardiac tissue
University of Connecticut

Researchers in the Biomedical Engineering Department at UConn have developed a new cardiac cell-derived platform that closely mimics the human heart, unlocking potential for more thorough preclinical drug development and testing, and model for cardiac diseases.

Released: 11-Aug-2022 2:25 PM EDT
KidneyX Launches New Artificial Kidney Prize with $10.5 Million in Funding
American Society of Nephrology (ASN)

Today, the US Department of Health and Human Services (HHS) and the American Society of Nephrology (ASN) announced a new prize competition from the Kidney Innovation Accelerator (KidneyX) that seeks to further the development of a fully functional bioartificial kidney.

Newswise: Bioengineered cornea can restore sight to the blind and visually impaired
Released: 11-Aug-2022 2:10 PM EDT
Bioengineered cornea can restore sight to the blind and visually impaired
Linkoping University

Researchers and entrepreneurs have developed an implant made of collagen protein from pig’s skin, which resembles the human cornea.

Released: 11-Aug-2022 12:00 PM EDT
Exercise Training Remodels Adipocyte-Specific Extracellular Matrix Proteins and Alters Innervation and Vascularization in Inguinal White Adipose Tissue (iWAT)
Preprints

Pasquale Nigro, Maria Vamvini, Jiekun Jackie Yang, Tiziana Caputo, Li-Lun Ho, Danae Papadopoulos, Nicholas Philip Carbone, Royce Colin, Jie He, Hirshman Frederick Michael, Joseph Daniel White, Jacques Robidoux, Robert Hickner, Soeren

Released: 11-Aug-2022 12:00 PM EDT
Development of lacrimal gland organoids from iPSC derived multizonal ocular cells
Preprints

Melis Asal, Gamze Koçak, Vedat Sarı, Tuba Reçber, Emirhan Nemutlu, Canan Aslı Utine, Sinan Guven

Released: 11-Aug-2022 12:00 PM EDT
Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel disease mechanism
Preprints

Malte Loos, Birgit Klampe, Thomas Schulze, Xiaoke Yin, Konstantinos Theofilatos, Bärbel Ulmer, Carl Schulz, Charlotta Behrens, Tessa Van Bergen, Eleonora Adami, Henrike Maatz, Michaela Schweizer, Susanne Brodesser, Boris Skryabin,

Released: 11-Aug-2022 12:00 PM EDT
Deciphering transcriptional networks during human cardiac development
Preprints

Robin Canac, Bastien Cimarosti, Aurore Girardeau, Virginie Forest, Pierre Olchesqui, Jeremie Poschmann, Richard Redon, Patricia Lemarchand, Nathalie Gaborit, Guillaume Lamirault

Newswise: Where do clots begin? McMaster researchers create device to replicate conditions in blood vessels after grafts
Released: 11-Aug-2022 11:30 AM EDT
Where do clots begin? McMaster researchers create device to replicate conditions in blood vessels after grafts
McMaster University

McMaster researchers create device to replicate conditions in blood vessels after grafts

Newswise: Study finds that sound plus electrical body stimulation has potential to treat chronic pain
Released: 11-Aug-2022 8:00 AM EDT
Study finds that sound plus electrical body stimulation has potential to treat chronic pain
University of Minnesota College of Science and Engineering

A University of Minnesota Twin Cities-led team has found that electrical stimulation of the body combined with sound activates the brain’s somatosensory cortex, increasing the potential for using the technique to treat chronic pain and other sensory disorders.

   
Released: 10-Aug-2022 12:00 PM EDT
Severe Combined Immunodeficiency: Improved survival leading to detection of underlying liver disease
Preprints

Anusha Vittal, Nehna Abdul Majeed, Elizabeth Garabedian, Jamie Marko, David E Kleiner, Rob Sokolic, Fabio Candotti, Harry Malech, Theo Heller, Christopher Koh

Released: 10-Aug-2022 12:00 PM EDT
PVT1/miR-136/Sox2/UPF1 axis regulates the malignant phenotypes of endometrial cancer stem cells
Preprints

Qing Li, Fanfei Kong, Rong Cong, Jian Ma, Cuicui Wang, Xiaoxin Ma

Released: 10-Aug-2022 12:00 PM EDT
Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable
Preprints

Kseniia Sarieva, Theresa Kagermeier, Shokoufeh Khakipoor, Ezgi Atay, Zeynep Yentuer, Katharina Becker, Simone Mayer

Released: 9-Aug-2022 1:05 PM EDT
Gene editing via CRISPR/Cas9 can lead to cell toxicity and genome instability
Fundació Institut de Recerca Biomèdica (IRB BARCELONA)

Researchers at IRB Barcelona identify critical spots on the genome where gene editing could cause an unwanted response, and they provide recommendations for safer approaches.

Released: 9-Aug-2022 12:00 PM EDT
Mir-4699 Promotes the Osteogenic Differentiation of Mesenchymal Stem Cells
Preprints

Vahedeh Hosseini, Mahdi Paryan, Ameneh Koochaki, Henry Manuel Cesaire, Samira Mohammadi-Yeganeh

Released: 9-Aug-2022 12:00 PM EDT
Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction
Preprints

Fan-Yan Wei, Asuka Inoue, Akiko Ogawa, Seiya Ohira, Tatsuya Ikuta, Yuri Kato, Shota Yanagida, Yukina Ishii, Yasunari Kanda, Motohiro Nishida

Released: 9-Aug-2022 12:00 PM EDT
Hypoxia induces early neurogenesis in human fetal neural stem cells by activating the WNT pathway
Preprints

Devanjan Dey, Vadanya Shrivastava, Diksha Joshi, Chitra Mohinder Singh Singal, Sagar Tyagi, Muzaffer Ahmed Bhat, Paritosh Jaiswal, Jai Bhagwan Sharma, Jayanth Kumar Palanichamy, Subrata Sinha, Pankaj Seth, Sudip Sen

Released: 9-Aug-2022 12:00 PM EDT
Adipose tissue-derived stromal/stem cells transplantation + cholecalciferol in recent-onset type 1 diabetes patients: twelve months follow up.
Preprints

Joana Rodrigues Dantas, Débora Batista Araújo, Karina Ribeiro Silva, Débora Lopes Souto, Maria De Fátima Carvalho Pereira, RonirRaggio LUIZ, Cesar Claudio-Da-Silva, Carlos Eduardo Barra Couri, Angelo Maiolino, Carmen Lúcia Kuniyoshi Rebelatto, Débora Regina Daga, Alexandra Cristina Senegaglia,

Released: 9-Aug-2022 12:00 PM EDT
SMPD1 Expression Profile and Mutation Landscape Help Decipher Genotype–Phenotype Association and Precision Diagnosis for Niemann–Pick Disease Types A and B
Preprints

Ruisong Wang, Ziyi Qin, Long Huang, Huiling Luo, Han Peng, Xinyu Zhou, Zhixiang Zhao, Mingyao Liu, Pinhong Yang, Tieliu Shi

Newswise: Body Posture Affects How Oral Drugs Absorbed by Stomach
5-Aug-2022 3:10 PM EDT
Body Posture Affects How Oral Drugs Absorbed by Stomach
American Institute of Physics (AIP)

A common method of administering drugs is orally, by swallowing a pill or capsule. But oral administration is the most complex way for the human body to absorb an active pharmaceutical ingredient, because the bioavailability of the drug in the gastrointestinal tract depends on the medication's ingredients and the stomach's dynamic physiological environment. In Physics of Fluids, researchers from employ a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach – a "StomachSim" – to investigate and quantify the effect of body posture and stomach motility on drug bioavailability.

   
Released: 8-Aug-2022 2:20 PM EDT
Researchers developed a small molecule that makes immunotherapy available to all cancer patients
Tel Aviv University

Researchers at Tel Aviv University and the University of Lisbon have jointly identified and synthesized a small molecule that could be a more accessible and effective alternative to an antibody that is successfully used to treat a range of cancers.

Released: 8-Aug-2022 12:00 PM EDT
Origami-based Zygote structure enables pluripotent shape-transforming deployable structure
Preprints

Yu-Ki Lee, Yue Hao, Zhonghua Xi, Woongbae Kim, Youngmin Park, Kyu-Jin Cho, Jyh-Ming Lien, In-Suk Choi



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