Feature Channels: Transplantation

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For athletes and highly active patients who sustain cartilage injuries to their knee, an osteochondral allograft transplantation can be a successful treatment option, according to research presented today at the American Orthopaedic Society for Sports Medicine’s (AOSSM) Annual Meeting in Colorado Springs, CO. The study showed these patients were consistently able to return to sport or recreational activities after the surgery, though frequently at a lower activity level.

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Rush University Medical Center received the ELSO Award for Excellence in Life Support – the most prestigious designation in critical care by the Extracorporeal Life Support Organization. Rush is the only full service adult and pediatric academic medical center in Chicago and Illinois to receive the Designated Gold Level Center of Excellence designation.

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A phase II clinical trial in people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, suggests that transplanting human stem cells into the spinal cord may be done safely. The research is published in the June 29, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology. While the study was not designed to determine whether the treatment was effective, researchers noted that it did not slow down the progression of the disease.

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Last year, the most extensive clinical face transplant to date was successfully carried out at NYU Langone Medical Center. A complete report on this procedure—including the extensive organizational and training program created to prepare for it—is published in the July issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

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Transplant Genomics Inc.® (TGI) is collaborating with the Mayo Clinic Center for Individualized Medicine to develop, validate and commercialize diagnostic tests enabling personalized immunosuppression for solid organ transplant recipients.

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In a first-of-its-kind procedure in the United States, a patient was able to avoid dialysis when surgeons simultaneously removed two diseased kidneys and also transplanted a kidney from a living donor – all as part of a 28-person paired kidney exchange

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A Case Western Reserve University School of Medicine faculty member has received $998,500 from the U.S. Department of Defense to develop a new approach to improve the quality and quantity of limbs and tissues obtained from brain dead organ donors. Benefits also could be extended to the more standard transplanted organs (e.g. kidneys, hearts, and lungs).

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A kidney transplantation means much more than good health to Jason E. Jones. The 53 year-old Hyde Park artist and Loyola Medicine patient draws daily creative inspiration from his chronic health experience. "My new kidney changed not only my life but my life's work," said Mr. Jones, who has been an artist for two decades. "My whole health journey became part of my artistic process and my daily experiences with medication and dialysis were incorporated into my artwork."

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A Loyola Medicine liver transplant patient won three medals and a heart transplant won one medal during the 2016 Transplant Games.

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Cloyd Goley of Farmersville, Ohio was suffering from a debilitating lung disease when he read a newspaper story that gave him hope.

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Up to 30 percent of people who receive organ transplants will develop diabetes, but researchers are unsure why. A new study in kidney transplant recipients suggests that patients with more inflammation prior to surgery are more likely to develop diabetes than those with less overall inflammation, and that a patient’s fat stores also play a role.

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Researchers from the University of Chicago have shown that microbiota—the bacteria, viruses and other microbes living on the skin and in the digestive system—play an important role in the body’s ability to accept transplanted skin and other organs.

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Montefiore Health System has a new collaborative program with its partner St. John’s Riverside Hospital to offer patients suffering from kidney, pancreas or liver disease an opportunity to be evaluated for transplantation at St. John’s Riverside Hospital by specialists from Montefiore Einstein Center for Transplantation.

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New Living Donor Navigator Program tailored to African-Americans and a new Facebook app aim to increase access to living kidney transplants and reduce the number of patients awaiting transplant.

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Early findings by researchers at the University of Cincinnati (UC) College of Medicine suggest that the use of a second generation cancer drug, carfilzomib, may provide an improved approach for the reduction of antibodies in potential kidney transplant candidates.

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Surgeons at the University of Illinois Hospital & Health Sciences System have — for the first time — used an orphan drug to prevent rejection of a kidney transplanted from a living donor with a mismatched blood type.

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Living donors are an increasingly important source of organs for kidney and liver transplantation, giving the world transplant community the responsibility to minimize the benefits to recipients while minimizing the risks to donors. The June issue of Transplantation, the official Journal of The Transplantation Society and the International Liver Transplantation Society, brings brought together the most current data and the best analysts to provide a whole issue devoted to living-donor transplantation. The journal is published by Wolters Kluwer.

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More than a year after leaving the hospital without a human heart, Stan Larkin, 25, trades his wearable total artificial heart for a real one.

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Transplant surgeons at UT Southwestern Medical Center have performed the first lung transplant in Texas using donated lungs treated with new technology known as ex-vivo lung perfusion.

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Four years ago at the Donate Life Transplant Games of America, liver transplant patient Geno Bianchi won gold medals in volleyball and doubles bowling and a silver medal in basketball. Mr. Bianchi, 28, will be competing in the same three events in the 2016 Transplant Games June 10-15 in Cleveland. This year, he hopes to win three golds.

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Simultaneous transplantation of a "composite" skull and scalp flap plus a kidney and pancreas—all from the same donor—provided excellent outcomes for a patient with a non-healing scalp defect and declining organ kidney and pancreas function, according to a report in the June issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

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A 13-year-old Norfolk girl is the first patient to receive a transplant in a unique pediatric liver transplant partnership between Children’s Hospital of Pittsburgh of UPMC and the University of Virginia Children’s Hospital.

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In addition the technique to grow the blood vessels in a 3D scaffold cuts down on the risk of transplant rejection because it uses cells from the patient. It was developed by researchers from the University of Bath's Department of Pharmacy and Pharmacology, working with colleagues at Bristol Heart Institute.

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Researchers at Lund University in Sweden have used a completely new preclinical technique and analysis of tissue from patients to show exactly what happens when certain patients with Parkinson's disease are restored as a result of nerve cell transplants. They have also identified what makes many of the transplant patients develop serious side effects in the form of involuntary movements.

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In the late 1980s and over the 1990s, researchers at Lund University in Sweden pioneered the transplantation of new nerve cells into the brains of patients with Parkinson’s disease. The outcomes proved for the first time that transplanted nerve cells can survive and function in the diseased human brain. Some patients showed marked improvement after the transplantation while others showed moderate or no relief of symptoms. A small number of patients suffered unwanted side-effects in the form of involuntary movements.

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Researchers have safely transplanted stem cells derived from a patient’s skin to the back of the eye in an effort to restore vision. The research is being presented at the 2016 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Seattle, Wash.

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A Loyola University Medical Center patient underwent a successful liver/kidney transplant to treat nonalcoholic steatohepatitis (fatty liver disease).

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This ARVO Meeting showcases cutting-edge eye and vision science and an early glimpse into the latest advances in potential treatments for eye disease and blindness — often years ahead of their introduction to the clinic.

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People who had cancer before receiving an organ transplant were more likely to die of any cause, die of cancer or develop a new cancer than organ recipients who did not previously have cancer, a new paper has found. However, the increased risk is less than that reported in some previous studies.

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The American Society of Nephrology (ASN) is one of two leading kidney health organizations participating in Kidney Health Advocacy Day 2016 in Washington, DC. Advocates from ASN and the American Association of Kidney Patients (AAKP) will meet with Congressional offices to call for lawmakers’ support of the Living Donor Protection Act of 2016. Kidney health providers and patients will urge passage of the legislation that would eliminate barriers to living donation and help increase access to lifesaving transplants.

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Susan Hou, MD, who altruistically donated a kidney to one of her patients and later became a recipient of a lung transplant, is among the transplant patients who will be honored April 21 during Loyola University Medical Center’s 25th annual Candle-lighting Ceremony.

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Surgeons at UT Southwestern Medical Center’s William P. Clements Jr. University Hospital successfully completed the first combined lung and liver transplant in North Texas on a 25-year-old Gainesville man – the 75th patient nationwide to receive the rare double-organ transplant. Josiah Ferrell of Gainesville is now able to walk outside without the oxygen tank he has carried around 24 hours a day and breathe in the fresh air of the outdoors for the first time in about two years.

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After a kidney transplant, women may experience decreased kidney damage from ischemia reperfusion injury compared to men due to the impact of gender-specific hormones, suggests a new preclinical study and an analysis of patient data published online in the Journal of Clinical Investigation from researchers at the Perelman School of Medicine at the University of Pennsylvania.

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A new study from physicians at Mayo Clinic in Rochester, found there may be long-term benefits to simultaneous liver-kidney transplantation versus kidney transplantation alone.

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High-volume lung transplant centers have lower transplantation costs and their patients are less likely to be readmitted within 30 days of leaving the hospital following surgery, according to a new study of more than 3,000 Medicare patients who received lung transplants.

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A complication associated with bone marrow transplantation, graft-versus-host-disease occurs when a transplanted immune system attacks certain parts of a host’s body, and may cause severe dry eye and damage to the cornea. A clinical trial at Massachusetts Eye and Ear showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication that may cause a rise in eye pressure and other ocular complications.

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Bill Spence feels so good since receiving a heart transplant at Loyola University Medical Center that he’s planning to hike the Appalachian Trail to raise awareness for organ donation. Mr. Spence hopes to sign up 2,190 donors – one for each mile of the trail

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Gift from United Therapeutics will establish UAB Xenotransplantation Program and bring additional resources to support the endeavor with a goal of genetically modified kidney transplants taking place by 2021.

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Tector’s arrival will bring the addition of a multivisceral and small bowel transplant program to UAB’s Division of Transplantation.

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Experts from Johns Hopkins, less than a week after announcing the world’s first HIV+ to HIV+ liver transplant, outline the special ethical concerns of such transplants in the Annals of Internal Medicine.

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New research suggests pretreating cells with a peptide hormone may improve the success rate of pancreatic islet cell transplants, a procedure that holds great promise for curing Type 1 diabetes. The results will be presented Saturday, April 2, at the Endocrine Society’s annual meeting, ENDO 2016, in Boston.

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At age 74, Loyola University Medical Center patient Brian Andersen recently became what is believed to be the oldest patient in Illinois to receive a lung transplant. And he feels terrific.As Mr. Andersen’s case illustrates, the upper age limit for lung transplantation has been increasing steadily.

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Loyola University Medical Center thoracic surgeon Wickii Vigneswaran, MD, is chief editor of the definitive new textbook, “Lung Transplantation: Principles and Practice.”

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• Among 10,533 kidney transplant recipients, 57% visited an emergency department within 2 years after transplantation. • Risk factors for emergency department visits included younger age, females, black and Hispanic race/ethnicity, public insurance, depression, diabetes, peripheral vascular disease, and use of emergency departments prior to transplantation.

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In what is certain to be an emotional church service, prominent Chicago minister Rev. Joseph Kyles will return to his pulpit Easter Sunday for the first time since undergoing a life-saving double-lung transplant.