Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant, and three times more likely to die of the dangerous skin cancer, suggests new research led by a Johns Hopkins Bloomberg School of Public Health student.
Mild hypothermia in deceased organ donors significantly reduces delayed graft function in kidney transplant recipients when compared to normal body temperature, according to UCSF researchers and collaborators, a finding that could lead to an increase in the availability of kidneys for transplant.
Following several years of research and collaboration, physicians and engineers at Johns Hopkins and Walter Reed National Military Medical Center say they have developed a computer platform that provides rapid, real-time feedback before and during facial transplant surgery, which may someday improve face-jaw-teeth alignment between donor and recipient.
Mayo Clinic is announcing results of a study on the effectiveness of left-ventricular assist devices (LVAD) in treating patients with a form of cardiomyopathy called restrictive cardiomyopathy (RCM).
Surgeons at The Children’s Hospital of Philadelphia (CHOP) joined with colleagues from Penn Medicine recently to complete the world’s first bilateral hand transplant on a child. Earlier this month, the surgical team successfully transplanted donor hands and forearms onto eight-year-old Zion Harvey who, several years earlier, had undergone amputation of his hands and feet and a kidney transplant following a serious infection.
UCLA Health and One Legacy honor organ, eye and tissue donors
The average wait time for a kidney transplant is five years and there are more than 100,000 people on the waiting list. However, there are thousands of viable hepatitis C-positive kidneys that are discarded each year solely because they’re infected. A new perspective paper in The New England Journal of Medicine suggests that “new antiviral therapies with cure rates exceeding 95 percent should prompt transplant-community leaders to view HCV (hepatitis C virus)-positive organs as a valuable opportunity for transplant candidates with or without pre-existing HCV infection.”
A deceased donor liver has been preserved and kept healthy outside the body in a device that mimics the body’s physiological functions and successfully transplanted into a human, for the first time in Ontario.
Researchers at Mayo Clinic have developed and are testing an alternative to liver transplantation called the Spheroid Reservoir Bioartificial Liver that can support healing and regeneration of the injured liver, and improve outcomes and reduce mortality rates for patients with acute liver failure.
As bone marrow and lung stem cells are quite similar, the Weizmann Institute’s Prof. Yair Reisner investigated whether transplant methods used for bone marrow might also work for treating lung diseases such cystic fibrosis and asthma. When mice with lung damage were given the new stem cell treatment, their lungs healed and breathing improved.
Organ transplant rejection in hosts that were previously tolerant may not be permanent. Using a mouse model of cardiac transplantation, scientists from the University of Chicago found that immune tolerance can spontaneously recover after infection-triggered rejection, and that hosts can accept subsequent transplants as soon as a week after.
The McMaster team recruited 75 patients with a flare up of their ulcerative colitis and randomized them to fecal transplant therapy given as an enema derived from stool donated by an anonymous healthy donor, and placebo.
Other topics include: breast cancer, blood thinners and surgery, cognitive impairment, and new ultra-dark galaxies discovered.
The University of Kansas Cancer Center’s Bone Marrow Transplant program is participating in a nationwide clinical trial that analyzes outcomes after two common treatments: bone marrow transplant and chemotherapy. The results could lead to wider access to transplants.
Two studies demonstrate that hyperlipidemia (high cholesterol and high triglycerides in the blood) caused by a high-fat diet accelerates heart-transplant rejection in mice. The researchers from Tufts University School of Medicine also found that simply feeding mice a high-fat diet increased organ rejection.
Ten years after undergoing a heart-lung transplant, Andrew Gaumer is looking forward to first Father’s Day. Andrew's wife gave birth to their first child on Mother's Day.
Aging can cause many changes to the body, including obesity and a loss of lean mass. Now, a group of University of Florida Health researchers has discovered that an existing drug reduces body fat and appetite in older rats, which has intriguing implications for aging humans.
A joint investigation including UT Southwestern Medical Center has found a molecule that may play a significant role in accelerating cell recovery following bone marrow transplants, liver disease, and colon disease.
In a study published in Science June 12, Case Western Reserve and University of Texas-Southwestern researchers detail how a new drug repaired damage to the colon, liver and bone marrow in animal models — even saving mice who otherwise would have died in a bone marrow transplantation model.
Blood and Marrow Transplantation (BMT) is a potentially curative treatment for patients with leukemia or other life-threating blood diseases. With a goal of increasing survival rates, a research team led by Roswell Park Cancer Institute (RPCI) investigators verified patient outcome data submitted by more than 150 U.S. transplant centers over an 11-year period to the Center for International Blood and Marrow Transplant Research (CIBMTR). The detailed investigation — published in the journal Biology of Blood and Marrow Transplantation — offers insight into different causes of death. The results of this genome-wide association study led to the development of a first-of-its-kind definition of specific causes of mortality after unrelated-donor, or allogeneic, BMT.
Older patients who received stem cells from younger, unrelated donors with higher numbers of so-called killer T cells (CD8 cells) had significantly reduced risk of disease relapse and improved survival compared to those who received stem-cells from donors with low numbers of CD8 cells, including older matched siblings.
Trending news releases with the most views in a single day. Topics include: marijuana exposure in children, female viagra, botox for nerve pain, genetics, cancer and bone marrow transplants, stroke, dengue fever, and memory loss in epilepsy.
Bone marrow transplant and hematology specialist Hillard M. Lazarus, MD, Professor of Medicine at Case Western Reserve University (CWRU) School of Medicine
Surgical teams from Houston Methodist Hospital and The University of Texas MD Anderson Cancer Center successfully transplanted, for the first time, a scalp and skull while performing kidney and pancreas transplants.
Surgical teams from Houston Methodist Hospital and The University of Texas MD Anderson Cancer Center successfully transplanted, for the first time, a scalp and skull while performing kidney and pancreas transplants.
Researchers at Wake Forest Baptist Medical Center report progress in their goal to make use of the more than 2,600 kidneys that are donated each year, but must be discarded due to abnormalities and other factors. The scientists aim to “recycle” these organs to engineer tailor-made replacement kidneys for patients.
More than 123,000 Americans are currently waiting for lifesaving organ transplants, but 21 patients die each day because there aren't enough organs to go around. New research shows wide variation in the number of eligible organ donors whose loved ones consent to organ donation across the country. Donation consent rates are highest in the Midwest and lowest in New York State, according to a study by researchers from the Perelman School of Medicine at the University of Pennsylvania and the University of Kansas Hospital in the new issue of the American Journal of Transplantation.
The Mount Sinai Health System today announced its support for, and membership in, the Coalition for Organ Distribution Equity (CODE).
Patients with liver cancer can be cured with a liver transplant. But because of the shortage of donated organs, these patients often die waiting for a liver. That’s because most transplant centers predominantly use livers from donors who die from brain death.
Lung transplant candidates who are about 5’3” or shorter have longer waiting times than taller candidates and are more likely to die within a year while waiting for a lung transplant, according to a study presented at the 2015 American Thoracic Society International Conference.
Obesity is a complicating factor for many surgical patients. In a recent study published in the Journal of Heart and Lung Transplantation, Mayo Clinic researchers have shown that losing weight can have a positive impact on outcomes for lung transplant patients.
A study, published online ahead of print May 14 in the American Journal of Transplantation, revealed that there are nearly 400 HIV-positive potential organ donors who could be sources of donated organs annually for HIV-positive patients waiting for organ donations.
A fairly simple and ethical change in policy would greatly expand the nation’s organ pool while respecting autonomy, choice, and vulnerability of a deceased’s family or authorized caregiver, according to ethicists at NYU Langone Medical Center.
Research found no racial or ethnic disparities among patients who participate in the Blood and Marrow Transplantation (BMT) Program at Roswell Park Cancer Institute (RPCI). The results were published in a recent issue of the journal Biology of Blood and Marrow Transplantation.
An international team of gastroenterologists, pediatricians, natural products chemists, and veterinarians, working with zebrafish models and mouse cell cultures have discovered that a chemical found in Australian plants provides insights into the cause of a rare and debilitating disorder affecting newborns called biliary atresia, the most common indication for a liver transplant in children.
Mayo Clinic transplant researchers will present findings from nearly 20 studies at the American Transplant Congress in Philadelphia, Penn., on May 2-5. Mayo Clinic is nationally recognized for research and clinical success in transplantation, and performs over 1,000 solid organ transplants each year.
• Members of the public in Australia considered reimbursement and justifiable recompensation of costs related to organ donation to be legitimate ways of supporting living donors. • Financial payment beyond reimbursement was regarded as morally reprehensible.
Heart transplant surgeons from Mayo Clinic are presenting findings from three recent clinical studies involving heart transplant patients. The presentations took place during the 2015 International Society of Heart & Lung Transplant (ISHLT) in Nice, France, on April 15–18.
The Cedars-Sinai Heart Institute completed 120 adult heart transplants and two adult heart-lung transplants in 2014, setting a new national standard for the most adult heart transplants performed in a single year.
A new study from the Liver Center at Beth Israel Deaconess Medical Center (BIDMC) suggests that standard assessments that nurses already use to care for patients can be mined for data that significantly improve the ability to predict survival following liver transplantation and may help improve patient outcomes.
It’s been 10 years since Andrew Gaumer received a life-saving heart and double-lung transplant at Loyola University Medical Center. “Every day since then has been a gift,” he said.
The shortage of kidneys needed for organ transplantation in the U.S. can be alleviated in part by using select kidneys with Acute Kidney Injury (AKI), resulting in safe and positive outcomes, according to research conducted at Mayo Clinic in Arizona.
HIV (human immunodeficiency virus)-positive kidney transplant patients experienced superior outcomes when compared to kidney transplant patients with Hepatitis C and those infected with both HIV and Hepatitis C, according to a study led by researchers at the Perelman School of Medicine at the University of Pennsylvania and published online in Kidney International.
At 77, John Bunton rode a ski lift up a mountain near Ogden, Utah, and spent an hour hiking around at 11,000 feet, admiring the craggy scenery and breathing in deeply the crisp mountain air. In June, he plans to walk his daughter down the aisle
• For older patients in need of a kidney transplant, rapid transplantation from an older deceased donor is superior to delayed transplantation from a younger donor. • Kidneys from older donors do not have sufficient longevity to provide younger patients with a lifetime of kidney function, but they do have sufficient longevity to provide older patients who have a shorter life expectancy with a lifetime of kidney function.
Kidney transplantation outcomes from deceased African-American donors may improve through rapid testing for apolipoprotein L1 gene (APOL1) renal risk variants at the time of organ recovery, according to a new study led by researchers at Wake Forest Baptist Medical Center.
Publicly insured Americans who undergo lung transplantation for cystic fibrosis fare markedly worse in the long run than both publicly insured patients in the United Kingdom and privately insured Americans, according to the results of a study conducted by researchers from Johns Hopkins in Baltimore and U.K. colleagues working in that nation’s government-funded National Health Service.
• Compared with uninfected (HIV-/HCV-) kidney transplant recipients, mono-infected HIV+ (HIV+/HCV-) recipients had similar 5-year and 10-year kidney survival rates, while HIV+ recipients co-infected with HCV (HIV+/HCV+) had worse kidney survival rates. • Patient survival among mono-infected HIV+ recipients was similar to uninfected recipients but was significantly lower for co-infected recipients.
Researchers have pinpointed the immune system mechanism that allows a kidney transplant to be accepted without lifelong immunosuppressive drugs, a significant step toward reducing or eliminating the need for costly and potentially toxic immunosuppressant drugs and improving long-term transplant success.
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