Middle-aged people who experience temporary blood pressure drops that often cause dizziness upon standing up may be at an increased risk of developing cognitive decline and dementia 20 years later, new Johns Hopkins Bloomberg School of Public Health research suggests.
A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.
A new international study co-led by a Rush University Medical Center researcher suggests that a drug starting through the pipeline could ameliorate or even eliminate the symptoms in most sufferers.
• Triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options. • BIDMC researchers discovered that TNBC cells increase production of pyrimidine nucleotides in response to traditional chemotherapy. • Discovery represents a vulnerability that can be exploited by blocking pyrimidine using an existing inhibitor in combination with chemotherapy.
Doctors are ordering too many liver-related blood tests at the same time, new research shows, which may lead to unneeded worry, biopsies and costs. Instead of “overtesting”, the researchers say, doctors should exclude common liver issues before testing for the uncommon ones, and healthcare computer systems should help.
A Phase III clinical trial involving 101 centers in 21 countries revealed the monoclonal antibody blinatumomab to be more effective than standard chemotherapy for treatment of advanced acute lymphoblastic leukemia (ALL). Study findings were published in the March 1 online issue of the New England Journal of Medicine.
Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common type of leukemia in children and adults.
Leaders of the American College of Surgeons (ACS) and the Committee on Trauma (COT) hosted a Congressional Briefing to highlight the ACS and Hartford Consensus bleeding control program.
Researchers at the University of Cincinnati (UC) College of Medicine have discovered a new potential strategy to personalize therapy for brain and blood cancers.
Intensive treatment to lower systolic (top number) blood pressure to below 120 would prevent 107,500 deaths per year in the United States, according to a study by researchers at Loyola University Chicago and other centers.
Upstate Medical University has opened a $15 million, 20,000 square foot cord blood bank that features a state of the art processing laboratory and cryogenic storage containers that can store nearly 14,500 units of cord blood. The bank will collect, test, process, store and distribute umbilical cord blood donated by families throughout central and northern New York to be used by those in need of life-saving medical treatments and for medical research.
A unique study recently published in the authoritative Pediatric Nephrology medical journal shows that excess lipoproteins and fatty acids may be associated with the development of painful and often chronic kidney stones in children.
• Receiving advice on limiting salt consumption helped kidney disease patients lower their systolic blood pressure by an average of 11 mmHg. • Limiting salt intake also reduced excess fluid retention that is common among patients with kidney disease.
New UF/IFAS Extension program aims to help people around Florida maintain healthy blood pressure.
Spinal cord injury patients are at higher risk for cardiovascular disease; pneumonia; life-threatening blood clots; bladder, bowel and sexual dysfunction; constipation and other gastrointestinal problems; pressure ulcers; and chronic pain.
Keeping blood sugar levels within a safe range is key to managing both type 1 and type 2 diabetes. In a new finding that could lead to fewer complications for diabetes patients, Yale School of Medicine researchers have found that changes in the size of mitochondria in a small subset of brain cells play a crucial role in safely maintaining blood sugar levels.
While several circulatory system models are used today in an attempt to better understand blood flow, they still don’t account for the complex rheological behavior of blood. Because blood is a complex suspension of red and white blood cells and platelets suspended within a plasma that contains various proteins, it can exhibit complex flow behavior. Many of the models currently used ignore these complexities and assume a Newtonian behavior or a constant thickness. During a Society of Rheology meeting, being held Feb. 12-16, Jeffrey S. Horner will present a new approach.
Researchers have projected that aggressively lowering blood pressure could help prevent more than 100,000 deaths in the U.S. each year. Experts from the University of Utah and institutions across the country built upon the landmark Systolic Blood Pressure Intervention Trial which found that decreasing blood pressure to 120 mmHg compared to 140 mmHg reduced heart attack, stroke and death in people that were at high risk. Until now, the number of lives that could be saved was unknown.
Researchers at Mount Sinai Health System have discovered a way to predict whether blood cancer patients who received a bone marrow transplant will develop graft-versus-host disease, a common and often lethal complication, according to a study published in JCI (The Journal of Clinical Investigation) Insight.
A blood test used to determine the health and well-being of dialysis patients produces worryingly inconsistent results depending on which testing method is used, new research reveals.
A new stent opens up iliac arteries, the three arteries that run from the end of the aorta down to the pelvis and legs. When these arteries are clogged it can cause a whole host of problems.
The Vasculitis Foundation announced today that the 2017 International Vasculitis Symposium will take place from Friday, June 23 to Sunday, June 25 at the Chicago Marriott O’Hare in Chicago, Illinois.
NCCN has published the NCCN Guidelines for Patients® and NCCN Quick Guide™ sheet for Waldenström’s Macroglobulinemia—a rare, but manageable type of Non-Hodgkin’s Lymphoma.
Researchers have found that the microorganisms residing in the intestines (microbiota) play a role in the development of high blood pressure in rats. The study is published in Physiological Genomics. It was chosen as an APS select article for February.
The Peter Munk Cardiac Centre at Toronto General Hospital today announced the launch of the FIBrinogen REplenishment in Surgery (FIBRES) study in acquired fibrinogen deficiency.
UT Southwestern Medical Center research supports an evidence-based medicine (EBM) approach that embraces individualized care to prevent overtreatment, specifically for patients with type 2 diabetes.
How do white blood cells - the immune cells that race to the sites of infection and inflammation - actually get to their targets? The research of Prof. Ronen Alon has revealed that the white blood cells actually force their way through the blood vessel walls to reach the infection, creating large holes.
In a second human case, a Yale-led research team has found that a melanoma cell and a white blood cell can fuse to form a hybrid with the ability to metastasize. The finding provides further insight into how melanoma and other cancers spread from solid tumors with implications for future treatment.
Donating blood is a tangible way to help people who are struggling with serious health conditions, yet many people may not think about it or make time for it.
Johns Hopkins researchers report that a new peptide holds promise for improving treatment for degenerative retinal diseases, such as age-related macular degeneration, diabetic macular edema and diabetic retinopathy. These vascular diseases often result in central vision loss as blood vessels grow into tissues at the back of the eye, where such growth should not occur.
A collaborative effort to improve the development of computational fluid dynamics (CFD) methodologies for evaluating "blood contacting" medical devices—receiving the Willem Kollf Award for top abstract at the ASAIO 2016 conference—is now reported in full in the ASAIO Journal, published by Wolters Kluwer.
Critically ill infants and children do not gain extra benefit from control of their blood sugar level to lower levels, compared to higher levels within the usual care range, say researchers who led a national clinical trial. While both levels of blood sugar control were relatively safe, control to lower levels increased the risk of a very low blood sugar (hypoglycemia) without offering a significant advantage.
A study published in the American Journal of Epidemiology reveals that the U.S. prevalence of masked hypertension is 12.3 percent. Based on the U.S. population, this translates to approximately 17.1 million people, or 1 in 8 adults
Researchers from Florida Atlantic University and Harvard Medical School address the possible but unproven link between statins and diabetes, as well as the implications of prescription of statins for clinicians and their patients. They emphasize that the risk of diabetes, even if real, pales in comparison to the benefits of statins in both the treatment and primary prevention of heart attacks and strokes. The editor-in-chief published the commentary and his editorial online ahead of print.
Using data from a national study, Johns Hopkins researchers determined that using heart CT scans can help personalize treatment in patients whose blood pressure falls in the gray zone of just above normal or mild high blood pressure.
Studies show that people who are chronically lonely have significantly more heart disease, are more prone to advanced cancers and strokes, and are more likely to develop neurodegenerative diseases such as Alzheimer’s.
The Council advises on matters relating to the cause, prevention, diagnosis and treatment of heart, blood vessel, lung and blood diseases; the use of blood and blood products and the management of blood resources; and on sleep disorders.
• In a phase 3 trial of patients with chronic kidney disease, 52.1% of patients receiving oral ferric citrate experienced a significant boost in hemoglobin levels (a reflection of red blood cell counts) compared with 19.1% of patients receiving placebo. • A treatment effect was seen as early as 1-2 weeks after the start of treatment, and the response was durable.
Warfarin is a commonly prescribed blood thinner used to prevent harmful blood clots. However, the drug requires frequent monitoring, daily dosing and can result in serious negative effects when mixed with vitamin K, a vitamin commonly found in vegetables such as lettuce or broccoli. Now, a new study from University of Missouri Health Care has found that using electronic health records (EHR) can improve the care patients receive after they leave the hospital and eliminate potential confusion among care providers and pharmacists.
Blood transfusions with the oldest blood available could be harmful for some patients, finds Columbia University researchers. The investigators recommend reducing the maximum blood storage limit from 6 to 5 weeks.
U.S. hospitals are reducing bloodstream infections related to catheters by implementing rigorous safeguards that also save millions of healthcare dollars each year, according to research led by Cedars-Sinai.
• Hemodialysis patients tend to have denser blood clots than individuals without kidney disease. • Dense blood clots were linked to an increased risk of premature death from cardiovascular and other causes.
The National Institutes of Health (NIH) is funding Canadian component of a study to determine the optimal amount of blood to transfuse in anemic patients who have suffered a myocardial infarction.
Researchers have found iron deficiency anemia protects children against the blood-stage of Plasmodium falciparum malaria in Africa, and treating anemia with iron supplementation removes this protective effect.
A life-threatening infection in an infant with leukemia led to a St. Jude Children’s Research Hospital discovery of how prolonged infection sets the stage for bacterial persistence despite antibiotic susceptibility.
Cincinnati Children’s researchers report in Nature Immunology a new mechanism that controls blood cell function and several possible molecular targets for treating myelodysplasia syndromes (MDS) – a group of pre-malignant disorders in which bone marrow does not produce enough healthy blood cells. MDS can lead to acute myeloid leukemia (AML), a fast-spreading blood cancer that can be deadly if not treated promptly.
Researchers are working to develop a pill to treat this serious inherited bleeding disorder. Oral delivery of the treatment--clotting factor IX--would allow individuals with type B hemophilia to swallow a pill rather than be subjected to several weekly injections of factor IX to control potentially fatal bleeding episodes.
The detection of prions in the blood of patients with variant Creutzfeldt-Jakob disease could lead to a noninvasive diagnosis prior to symptoms and a way to identify prion contamination of the donated blood supply, according to researchers at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).
Health and wellness tips about preventing blood shortages, cardiorespiratory fitness check-up, and avoid holiday heart syndrome.
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