UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions
A study in Nature shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.
Stem cells derived from a patient's own fat offer a step toward improving — not just stabilizing — motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic.
Dana-Farber Cancer Institute researchers will present more than 40 research studies at the 61st American Society of Hematology (ASH) Annual Meeting on December 7-10 in Orlando, Fla.
Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome (HLHS) and Children's of Alabama announce their collaboration within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.
Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study. The study, published in the journal Gastroenterology, describes a new connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice.
The 61st American Society of Hematology Annual Meeting and Exposition will take place Dec. 7–10 in Orlando, Florida
Researchers identified non-coding regions of the human genome that control the development and function of four brain cell types and mapped genetic risk variants for psychiatric diseases. They found that risk variants for Alzheimer’s disease were enriched in microglia-specific regulatory elements.
Dr. Eugene Chang was 25, recently engaged and halfway through a physical medicine and rehabilitation residency in Vancouver when he started feeling sick. Fatigue, dizziness and nausea took over his normally active lifestyle. Suddenly his bike to work was not so easy.
A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons), according to a study in the journal Nano Letters.
October 31, 2019 —The American Thyroid Association (ATA) announces a new ATA award recognizing and celebrating the work of young women that are leading outstanding thyroid research, Women Advancing Thyroid Research (WATR) Award. Sponsored by our publisher Mary Ann Liebert (https://home.liebertpub.com/) through the Rosalind Franklin Society (https://www.
In a Phase One-Two clinical trial, the great majority of patients with blood cancers are on the road to recovery, thanks to the UM171 molecule, discovered at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal.
In the first large-scale clinical study to characterize stem cells from the umbilical cord blood and tissues of premature infants with bronchopulmonary dysplasia – a severe, chronic lung disease – researchers found that these babies had more stem cells at birth. They also found that a growth factor (G-CSF), which is responsible for stem cell migration and differentiation, is decreased in these infants.
Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state’s stem cell agency.
Lurie Children's Hospital in Chicago adds another fetal surgeon to complement its robust program.
Two Florida State University researchers are developing a high-tech material currently used in athletic equipment and prosthetics into a special tool to better develop stem cells. The work could improve drug screening, disease modeling, precision medicine and cell therapy.
The National Comprehensive Cancer Network (NCCN) published new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Hematopoietic Cell Transplantation, (aka stem cell transplant or bone marrow transplant), with step-by-step information on best practices for this blood cancer treatment
The study, conducted in mice, is the first to show that creatine uptake is critical to the anti-tumor activities of killer T cells, the foot soldiers of the immune system.
With collaborating labs across the University of Washington campus and at other Seattle-area institutions and beyond, the Center for Translational Muscle Research will encompass a myriad of muscle science and disease investigations.
A genetic link has now been found for some instances of Sudden Infant Death Syndrome, or SIDS. The new UW Medicine research study is the first such to make an explainable link.
Now, in experiments in mice as well as isolated human cancer cells, UCLA researchers have discovered a way to eliminate the CML stem cells. Their approach uses an antibody to block a protein that the stem cells rely on to grow. The advance, described in a study published in the Journal of Clinical Investigation, might eventually help treat not only chronic myelogenous leukemia but other cancers as well.
As research involving the transplantation of human “mini-brains”—known as brain organoids—into animals to study disease continues to expand, so do the ethical debates around the practice. A new paper published in Cell Stem Cell by researchers from Penn Medicine and the Department of Veterans Affairs sought to clarify the abilities of brain organoids and suggests an ethical framework that better defines and contextualizes these organoids and establishes thresholds for their use.
MedStar Heart & Vascular Institute has enrolled its first patient to a clinical trial to determine whether cardiac stem cells reduce inflammation enough to improve heart function in patients with heart failure severe enough to require a left ventricular assist device, or LVAD.
Scientists show that the location of stem cells is essential in determining tapeworms’ ability to regenerate.
In experiments with mice, UCLA researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method, described in the journal Cell Stem Cell, suppressed the growth of multiple types of human tumors that had been transplanted into the animals.
In experiments with mice and human tissue samples, Johns Hopkins Medicine researchers report evidence that neuronal stem cells in the part of the nose responsible for the sense of smell transform themselves to perpetuate the long-term inflammation in chronic sinusitis.
An interdisciplinary team has found a solution to a problem plaguing developmental biology -- long-term cell tracking and manipulation. Researchers painstakingly developed an automated microfluidic device for the stable imaging of mice embryonic stem cells over a three-day period.
Researchers led by Sean I. Savitz, MD, of UTHealth Houston reported today in the journal Stem Cells that bone marrow cells used to treat ischemic stroke in an expanded Phase I trial were not only safe and feasible, but also resulted in enhanced recovery compared to a matched historical control group.
In experiments in mice, Johns Hopkins Medicine researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs.
UNM Cancer Center’s Bone Marrow Transplant program is the first in the state to achieve FACT accreditation, enabling many more New Mexicans with blood disorders to stay home
On the day he was born, Patrick Davey saved a woman's life. His parents donated his umbilical cord blood, which was used in a stem cell transplant that saved the life of cancer patient Holly Becker.
Nine-month-old brains-in-a-dish and the brains of premature newborn babies generate similar electrical patterns, as captured by electroencephalogram (EEG) — the first time such brain activity has been achieved in a cell-based laboratory model.
Scientists at the Morgridge Institute for Research have created a new way to study early human developmental timing through a stem cell-based “clock in a dish."
Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation.
The project is focused on identifying the role of hypoxia or lack of oxygen to the cells and tissues in the body, and oxygen on the formation of the eye lens.
The California Institute for Regenerative Medicine (CIRM) has awarded a $4.96 million grant to Sanford Burnham Prebys Professor Evan Y. Snyder, M.D., Ph.D. The funding will allow Snyder to complete pre-investigational new drug (IND)-enabling studies, a step toward securing U.S. Food & Drug Administration (FDA) approval of a human trial for neural stem cells as a potential treatment for newborns who experience oxygen and blood-flow deprivation during birth. Called perinatal hypoxic-ischemic brain injury (HII), the lack of oxygen and blood flow to the brain can cause cerebral palsy and other permanent neurological disorders.
Using an unbiased labelling technique, mathematical modelling, and single cell profiling to trace the footsteps of stem cells and their daughters, researchers at the University of Cambridge (UK), DGIST (S.Korea), and IMBA (Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria) have confirmed that two populations of adult stem cells with distinct roles and characteristics reside in the glands of the stomach.
A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants.
Nanotechnology developed at Rutgers University–New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer’s disease, Parkinson’s disease, other neurodegenerative diseases, and central nervous system injuries.
UC San Diego School of Medicine has been awarded $9 million to fund research projects using human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes aimed at identifying the cellular actions leading to disease onset.
Stem cells hold the key to wound healing, as they develop into specialised cell types throughout the body - including in teeth.
The heart cannot regenerate muscle after a heart attack. Injecting heart muscle cells grown in vitro could help the failing heart, but engraftment rates are low. A new and simple method to improve the quality of the delivered cells has now been tested in mice, and it doubles the engraftment rate.
In a proof-of-concept paper, Pitt researchers chronicle how they transformed genetically engineered human cells into functional, 3D liver tissue that mimics non-alcoholic fatty liver disease (NAFLD) – a condition involving fat buildup in the liver, which can lead to cirrhosis or even liver failure.
Mount Sinai researchers have developed a way to use immunotherapy drugs against treatment-resistant non-Hodgkin’s lymphomas for the first time by combining them with stem cell transplantation, an approach that also dramatically increased the success of the drugs in melanoma and lung cancer, according to a study published in Cancer Discovery in July.
Convelo Therapeutics Inc., a Cleveland company based on the research findings of Paul Tesar and Drew Adams at the Case Western Reserve University School of Medicine, has entered into a strategic partnership with Genentech to develop new therapeutic drugs to repair damaged myelin insulation on nerve cells for patients suffering from neurological disorders such as multiple sclerosis.
一项I期临床试验表明，通过采集和处理婴儿自体干细胞并在手术时直接将其注入心脏，有望对左心发育不良综合征(HLHS)进行再生治疗。该研究是美国食品药品监督管理局监测的首项同类研究。The Journal of Thoracic and Cardiovascular Surgery（《胸心血管外科杂志》）上发表了一篇详细介绍该临床试验的论文。
Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells — fat cells (adipocytes), bone-making cells (osteoblasts) and cartilage-making cells (chondrocytes).
Um estudo clínico de fase 1 é a primeira pesquisa monitorada pela Food and Drug Administration (Agência Americana de Controle de Alimentos e Medicamentos) que demonstra o potencial da terapia regenerativa para a síndrome da hipoplasia do coração esquerdo (SHCE) por meio de coleta, processamento e introdução das próprias células tronco da criança no coração durante o momento da cirurgia.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right