A new biomedical research study finds a transcription factor called Slug contributes to breast cell fitness by promoting efficient repair of DNA damage. The absence of Slug leads to unresolved DNA damage and accelerated aging of breast cells.
Eye research funders come together to foster research to treat age-related macular degeneration.
A worldwide coalition of researchers and clinicians has agreed that light therapy is among the most effective interventions for the prevention of oral mucositis, painful ulcers in the mouth resulting from cancer therapy.
Irvine, Calif., July 8, 2019 — University of California, Irvine researchers have developed and tested on mice a therapeutic treatment that uses engineered stem cells to target and kill cancer bone metastases while preserving the bone. This new approach, reported in the journal EBioMedicine, equips engineered mesenchymal stem cells with targeting agents that drive them to bone metastatic sites, where they offload therapeutics.
An interdisciplinary team of UCLA scientists has found that small cell neuroendocrine cancers from a range of tissues have a common molecular signature and share drug sensitivities with blood cancers.
UC San Diego will launch a payload of stem cell-derived human brain organoids to the International Space Station. Researchers will document how these “mini brains” organize into the beginnings of a functional brain with implications for the future of human life in space.
Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.
In cinema and science fiction, one small change in the past can have major, sometimes life-changing effects in the future. Using a series of snapshots, researchers recently captured such so-called “butterfly effects” in heart muscle cell development, and say this new view into the sequence of gene expression activity may lead to better understanding disease risk.
In a new study, aimed at using stem cells for hair growth, Columbia researchers have created a way to grow human hair in a dish, which could open up hair restoration surgery to more people, including women, and improve the way pharmaceutical companies search for new hair growth drugs.
Researchers at the University of Michigan Rogel Cancer Center and U-M College of Engineering have found that breast cancer cells that swallow up nearby stem cells take on some of their properties, enhancing their ability to invade other tissues throughout the body and seed secondary tumors, a process known as metastasis.
Scientists have developed a stem-cell-based modeling system that identifies how some neurons are resistant to ALS—a breakthrough that offers potential for battling neurodegeneration.
Researchers found that stem cells can commit to a cell fate far more rapidly than anticipated.
Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) discovered in laboratory studies that an experimental drug called selinexor may block a crucial survival pathway exploited by myelofibrosis cells.
Pregnant women are often advised to avoid certain drugs because of potential risks to their unborn infant's growing brain cells.
Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome and Ochsner Hospital for Children are collaborating within a consortium to provide solutions for patients with hypoplastic left heart syndrome (HLHS), a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.
A statewide bipartisan initiative is transforming health care from a focus on treating disease to one of tapping the body's ability to heal itself. Regenerative Medicine Minnesota is a legislative initiative aimed at improving health by advancing regenerative medicine in research, technology, education and patient care across the state.
Dr. Nathan Bryan, one of the nation’s top experts in the health effects of nitric oxide, is pleased to announce that Pneuma Nitric Oxide Activating Skin Serum™, a revolutionary, innovative and patent pending dual chamber technology that delivers nitric oxide gas to the surface of the skin is now available to men and women concerned about combatting the effects of aging skin.Dr. Nathan Bryan, one of the nation’s top experts in the health effects of nitric oxide, is pleased to announce that Pneuma Nitric Oxide Activating Skin Serum™, a revolutionary, innovative and patent pending dual chamber technology that delivers nitric oxide gas to the surface of the skin is now available to men and women concerned about combatting the effects of aging skin.
To treat large gaps in long bones, like the femur, that often eventually result in amputation, researchers developed a process that partially recreates the bone growth process that occurs before birth.
Researchers at the University of Illinois at Chicago and the University of Pennsylvania have developed a unique technique that uses stem cells and flexible implantable bone-stabilizing plates to help speed the healing of large breaks or defects. The technique allows the stem cells applied to break sites to experience some mechanical stress, as they do in developing embryos.
Irvine, Calif., June 5, 2019 — A nanotechnology treatment derived from bone marrow stem cells has reversed multiple sclerosis symptoms in mice and could eventually be used to help humans, according to a new study led by University of California, Irvine researchers. “Until now, stem cell therapies for autoimmune and neurodegenerative diseases have produced mixed results in clinical trials, partly because we don’t know how the treatments work,” said corresponding author Weian Zhao, an associate professor of pharmaceutical sciences and biomedical engineering who is affiliated with the Sue & Bill Gross Stem Cell Research Center.
As people age, their muscle regeneration capacity declines in part because they can no longer make enough muscle stem cells to replace damaged tissue.
Researchers analyzed biomarkers secreted from transplanted human stem cells in the recipient blood of a rodent model of heart attack. Analysis of the blood test showed responding cells had changed their gene expression, behavior and secretions, suggesting this liquid biopsy could provide a window into stem cell activity and effectiveness.
Johns Hopkins Medicine researchers report they have created a method of mapping how the central nervous system develops by tracking the genes expressed in cells. The technique, demonstrated in mouse retinas for this study, follows the activity of the genes used by individual cells during development, allowing researchers to identify patterns in unprecedented detail. This precise kind of road map, say the researchers, could be used to develop future regenerative treatments for blinding and other neurological diseases
University of Washington researchers developed a strategy to keep proteins intact and functional in synthetic biomaterials for tissue engineering. Their approach modifies proteins at a specific point so that they can be chemically tethered to scaffolds using light.
Study Identifies New Stem Cell Type That Can Significantly Improve Cardiac Function
UC San Diego researchers discover new role for epidermal growth factor receptor in blood stem cell development, a crucial key to being able to generate them in the laboratory, and circumvent the need for bone marrow donation.
The American Academy of Dermatology has honored oncologist Jennifer Whangbo, MD, PhD, and dermatologist Jennifer Huang, MD, FAAD, as Patient Care Heroes for their collaboration in caring for pediatric stem cell transplant patients.
More than one million stem cell treatments have been conducted in the United States during the past ten years. Physicians and other healthcare providers are beginning to realize regenerative medicine is the future of medicine; however major health issues remain unanswered. Dr. Nathan Bryan, one the country’s leading experts in the mechanism of nitric oxide, will tell more than seven thousand physicians attending the 27th Annual Spring Conference of the American Academy of Anti-Aging Medicine on Saturday that “the ability to use our own cells to heal our own body make good medical sense.
Scientists from Sanford Burnham Prebys have shown that a protein called BMI1 is a promising drug target for an AML subtype in which two normally separate genes, CALM and AF10, fuse together. The findings, published in Experimental Hematology, provide a rationale for evaluating a BMl1-inhibiting drug that is currently in clinical development for solid tumors.
Treating a stubborn blood disease that strikes children may come down to tweaking energy production in stem cells, suggests research out of West Virginia University. Wei Du, an assistant professor in the School of Pharmacy, is investigating the link between how stem cells make energy and how Fanconi anemia develops.
*For the first time, researchers have developed a non-intrusive way to generate large quantities of stem cells using only a small amount of blood* *The stem cells can repair cells damaged as a result of vascular diseases, which has the potential to prevent blindness and reverse the need for amputations*
Using stem cells derived from six people, UC San Diego School of Medicine researchers recapitulated retinal cells in the lab. This “eye-in-a-dish” model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.
Recent work highlights a better way to grow smooth muscle cells, one of the two cellular building blocks of arteries, from pluripotent stem cells. This research is part of an effort to create artery banks — similar to blood banks common today — with readily-available material to replace diseased arteries during surgery.
A new study published in Cell Reports by a team of researchers at the University of Wisconsin–Madison’s Wisconsin Institute for Discovery and School of Medicine and Public Health could improve the efficiency of creating induced pluripont stem cells.
Johns Hopkins scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells (iPSCs), make tiny “cargo packets” able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells. They say the human iPSCs they studied produced much more of the packets, formally known as extracellular vesicles, than other kinds of adult stem cells commonly used for this purpose in research.
Neurodegenerative diseases like multiple sclerosis (MS) affect millions of people worldwide and occur when parts of the nervous system lose function over time. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered that a type of skin-related stem cell could be used to help regenerate myelin sheaths, a vital part of the nervous system linked to neurodegenerative disorders.
The Immaculate Conception? Forget Sperm and Eggs, Hebrew University Researchers have Created Embryo Stem Cells from Skin Cells
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have been awarded a $4.6 million grant from the California Institute for Regenerative Medicine – also known as CIRM – to support a phase I clinical trial of a novel treatment for advanced sarcomas and other cancers with a specific tumor marker called NY-ESO-1.
UC San Francisco researchers have discovered a new type of stem cell in mouse muscles that is resistant to radiation and other forms of cellular stress. The findings have implications for improving recovery for cancer patients undergoing radiotherapy and could even lead to treatments to protect future astronauts from the ravages of deep-space radiation.
Scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.
A gene that is necessary for prenatal growth has been shown to be essential in maintaining crucial stem cells in the adult brain and intestine, a Rutgers study has discovered.
Bhatia’s team spent more than six years delving down to the cellular level to examine what they say are previously overlooked cells that form on the edges of pluripotent stem cell colonies. Having characterised these cells, the team also observed them form at the earliest stages of pluripotent cell reprogramming from adult cells. By understanding and isolating these cells on the edges using a tool called single-cell RNA sequencing gene expression analysis, the researchers discovered a subset of cells with characteristics that made them different from the cellular ecosystem surrounding them.
The molecular "scissors" known as CRISPR-Cas9 has transformed genetic research in recent years. Now, an international team has unveiled a new CRISPR-based tool that acts more like a shredder, able to wipe out long stretches of DNA in human cells with programmable targeting. It's based on Type I CRISPR-Cas3, which has been shown to work in human cells for the first time.
Moores Cancer Center at UC San Diego Health treats the first patient treated for cancer with a human-induced pluripotent stem cell (iPSC)-derived cell therapy called FT500. Dan Kaufman collaborated with Fate Therapeutics to bring the iPSC-derived natural killer cell cancer immunotherapy to patients.
Researchers have developed a method to grow and maintain olfactory stem cells. The work is a launch pad for developing stem cell transplantation therapies or pharmacologic activation of a patient’s own dormant cells, to restore the sense of smell where it has been damaged by injury or degeneration.
A little goes a long way. Tiny blood vessels are essential for regenerative engineering and a team led by engineers from Michigan Tech has detailed innovative methods to ensure highly aligned, dense and mature microvasculature in engineered tissue that can be used for cardiac patches.
While chronic myelogenous leukemia is in remission, ‘sleeper cell,’ quiescent leukemic stem cells persist in the bone marrow. Researchers find that niche-specific expression of chemokine CXCL12 by mesenchymal stromal cells controls quiescence of these treatment-resistant leukemic stem cells.
A new drug takes out the "seeds" that cause ovarian cancer to come back after chemo
Those with B-cell lymphomas that do not respond to standard therapies now have another treatment option in New Jersey, as CAR-T cell therapy is now being offered at Robert Wood Johnson University Hospital New Brunswick, an RWJBarnabas Health facility, in conjunction with Rutgers Cancer Institute of New Jersey.
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