Researchers have discovered how a gene that increases the risk of developing genetic heart disease functions, paving the way for new treatments.
The time has come to create a new kind of computer, say researchers from John Hopkins University together with Dr Brett Kagan, chief scientist at Cortical Labs in Melbourne, who recently led development of the DishBrain project, in which human cells in a petri dish learnt to play Pong.
UC Davis Health researchers have begun a new stem cell clinical trial to treat patients with swallowing problems. The study takes stem cells and injects them into the patient’s tongue.
UC San Diego’s new Astrobiotechnology Hub brings together leaders in academia, biotechnology and aerospace industries under a united mission to advance stem cell science and commercialization in space.
Diseases caused by ischemia are one of the leading causes of death in the world. Current therapies for treating acute myocardial infarction, ischemic stroke, and critical limb ischemia do not complete recovery. Regenerative therapies opens new
Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.
Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumour called a glioma.
Thrive Bioscience Inc., an innovative provider of automated live cell imaging instruments and software, debuts a new integrated suite of unique and exciting capabilities that significantly advance the field of live cell imaging.
UC San Francisco researchers have uncovered a surprising role for fibroblasts in the lungs in activating T cell inflammation that drives lung destruction in COPD exacerbation triggered by viral infection. They also identified a T cell subset that can be targeted to treat COPD exacerbations.
Below are some of the latest articles that have been added to the Chemistry news channel on Newswise.
Researchers from the Icahn School of Medicine at Mount Sinai have generated the first induced pluripotent stem cells (iPSCs) from bats, gaining valuable insights into the close relationship between bats and viruses.
UC San Diego researchers report that a late-stage, pre-clinical small molecule inhibitor reverses malignant hyper-editing by a protein that promotes silencing of the immune response, metastasis and therapeutic resistance in 20 different cancer types.
MD Anderson and Replay announced the launch of Syena, a new oncology-focused product company pioneering T cell receptor (TCR) natural killer (NK) cell therapies.
Computer software developed at Washington University School of Medicine in St. Louis can predict what happens to complex gene networks when individual genes are missing or dialed up more than usual. Mapping the roles of single genes in these networks is key to understanding healthy development and finding ways to regrow damaged cells and tissues. Likewise, understanding genetic errors could provide insight into birth defects, miscarriage or even cancer.
The Wake Forest Institute for Regenerative Medicine (WFIRM) and the Regenerative Medicine Foundation (RMF) have announced the 20th edition of World Stem Cell Summit will be held in conjunction with the 10th annual Regenerative Medicine Essentials Course, uniquely formatted this year for both in person and virtual attendance from June 5-9, 2023.
A new Cedars-Sinai study in collaboration with the University of California, Irvine (UCI) and the Answer ALS consortium has examined the expression of thousands of genes in stem cell generated motor neurons that are known to die in patients with amyotrophic lateral sclerosis, a fatal neurological disorder known as ALS or Lou Gehrig's disease.
CAR T-cell therapy, a certain kind of cancer treatment in which the immune system’s T cells are programmed to attack tumour cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer.
Reducing levels of a spliceosome-associated factor, SYF2, attenuates TDP-43 pathology in models of diverse forms of ALS. Therefore, these findings by Linares et al. indicate that SYF2 suppression may function as a broadly acting therapeutic strategy
Reducing levels of a spliceosome-associated factor, SYF2, attenuates TDP-43 pathology in models of diverse forms of ALS. Therefore, these findings by Linares et al. indicate that SYF2 suppression may function as a broadly acting therapeutic strategy
Chen and colleagues demonstrate that human brain organoids can integrate structurally and functionally with the injured adult mammalian brain. Organoid grafts connect synaptically with the rat brain and adopt the function of the visual cortex. These
Throughout an organism’s life, the activity of niche signals fluctuates due to injury, and stem cells need to respond accordingly. Klein and colleagues found that during high Wnt activity observed in intestinal regeneration, niche canonical WNT lig
Sebert, Gachet et al. analyzed longitudinal data from patients with Fanconi anemia, a rare inherited DNA-repair disease. They provided genomic and functional insights into MDM4-driven p53 response modulation yielding clonal hematopoiesis and precedi
The utilization of iPSC technologies to model neurological diseases in vitro is challenging due to the inherent tendency of neurons to aggregate and their immature profile. Kiskinis and colleagues developed artificial extracellular matrix biomimetic
Reducing levels of a spliceosome-associated factor, SYF2, attenuates TDP-43 pathology in models of diverse forms of ALS. Therefore, these findings by Linares et al. indicate that SYF2 suppression may function as a broadly acting therapeutic strategy
The maturation of human induced pluripotent stem cell (hiPSC)-derived neurons in 2D is dependent upon cell attachment, spreading, and pathfinding across a biomaterial substrate. In this issue of Cell Stem Cell, Álvarez et al.1 demonstrate that high
The generation of donor-derived induced pluripotent stem cells (iPSCs) for allogeneic transplantation is a major challenge in regenerative medicine. Yoshida et al. now report on the establishment of an HLA-homozygous haplobank of iPSCs that covers a
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
Irvine, Calif., Jan. 30, 2023 — Combating Alzheimer’s and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of Pennsylvania have found a way to safely thwart the brain’s resistance to them, vaulting a key hurdle in the quest.
BACKGROUNDThe therapeutic effects of various stem cells in acute liver failure (ALF) have been demonstrated in preclinical studies. However, the specific type of stem cells with the highest therapeutic potential has not been determined. AIMTo
Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have illuminated how treatments for multiple myeloma and other aggressive blood cancers can lead to future malignancies, called therapy-related myeloid neoplasms (tMNs).
In a new study using a rat model of Crohn’s disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown significant success in treating perianal fistulas (PAF) — one of the many complications of Crohn’s disease.
根据一项妙佑医疗国际(Mayo Clinic)的真实世界证据研究，将再生医学应用于常见的肩关节手术可能会对部分患者的后续修复手术需求产生影响。
إن تطبيق الطب التجديدي على إحدى جراحات الكتف الشائعة قد يكون له تأثيرٌ على الحاجة إلى جراحة مراجعة للمتابعة بالنسبة لبعض المرضى، وفقًا لدراسة مايو كلينك ذات الأدلة الواقعية. حيث حلل باحثو
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a custom-built application to automate determination of engraftment, a key outcome after hematopoietic stem cell transplant (HSCT). The application supersedes a tedious manual process and at the same time substantially improves accuracy of reported hematopoietic cell transplant engraftments.
Rockville, Md.—The Association for Research in Vision and Ophthalmology (ARVO) Foundation congratulates Miguel Flores-Bellver, PhD, recipient of the 2023 Bert M. Glaser, MD Award for Innovative Research in Retina. The award recognizes an early-career investigator who has made a novel discovery that impacted the understanding and/or treatment of a retinal disease or condition.
UC San Diego researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional treatments and spurring growth.
UC San Diego researchers identify mutation that causes excessive folding in human brain’s wrinkly cerebral cortex, resulting in diminished cognitive function.
The Stem Cell and Bone Marrow Transplant Program at Cedars-Sinai Cancer was recently recognized with two important hallmarks of quality: official accreditation for CAR T-cell therapy, and a third year in a row ranking among the top adult bone marrow transplant programs in the U.S.
A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate.
Researchers have uncovered sphingolipid accumulation as a new mechanism that affects ageing. Ceramides, the best-known class of sphingolipids, accumulate in aged muscle, impairing its function while also affecting functional capacity in older adults.
Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.
Most cells have a pretty normal life: they’re born, they grow, they get old, and they die. But the Benjamin Buttons of the cellular world can go from old to young again in the right context.
Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2 identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader I
Cheng et al. delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development and identify PRMT6, regulated by IGF2BP2, acting as a key for leukemia stem cell maintenance by restraining MFSD2A expression and docosahexaenoic ac
By generating a multiomic cell atlas of embryonic human lungs and establishing a human tip progenitor cell organoid culture system, two recent studies demonstrated the exciting research advances in human lung development.
Serrano et al. used human iPSC-derived cardiomyocytes and deep learning data analysis to establish an in vitro safety margin that predicts clinical proarrhythmic effects of drugs. Their platform shows high accuracy in identifying risky drugs as wel
Organoids provide a platform for recapitulating and exploring development, and synthetic biology offers a toolbox to genetically manipulate cell communication, adhesion, and even cell fate. Using modular synthetic biology tools in organoids will impr
Editors’ note: The Ogawa-Yamanaka Stem Cell Prize recognizes groundbreaking work in translational regenerative medicine using reprogrammed cells. The prize is supported by Gladstone Institutes, in partnership with Cell Press. This article features
While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro
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