U.S. physicians are increasingly ordering medications for children for conditions that are not approved by the Food and Drug Administration, according to a Rutgers study.
An international research team is perfecting a method to predict the potential clinical implications of new drugs before clinical trials even start.
The University of Illinois at Chicago opened three health care simulation centers that use specially trained actors, advanced and computerized manikins of all ages, and simulated environments to help students and health care professionals practice clinical skills, communication and decision-making skills, and get hands-on training in medical diagnosis, treatment and care.
Targeting the protein Eyes Absent 3 (EYA3) may help prevent vascular remodeling in pulmonary arterial hypertension (PAH), according to new study from Cincinnati Children's.
Science Snapshots: messenger proteins, new TB drug, artificial photosynthesis
Sixteen years ago, a research group at Mayo Medical School published results showing that a protein called TRAIL can kill cells that cause liver fibrosis but no one seemed to follow up on these findings. Now, researchers at Johns Hopkins Medicine have improved on this protein and shown that it selectively kills cells that cause the hardening of skin associated with scleroderma, effectively reversing the condition in mice genetically engineered to mimic the disease. A report on these results was published earlier this year in Nature Communications.
A growing body of evidence suggests that LSD, psilocybin, and other hallucinogenic drugs may have therapeutic benefits for patients with psychiatric disorders, according to a research review in the September issue of Journal of Psychiatric Practice. The journal is published in the Lippincott portfolio by Wolters Kluwer.
The University of Washington’s School of Pharmacy announced on Thursday, Sept. 12, a collaboration with global biopharmaceutical company UCB to improve access to care for people living with epilepsy. This interdisciplinary project will explore ways in which community pharmacists can better support people living with this neurological disorder.
Ventrix, a University of California San Diego spin-off company, has successfully conducted a first-in-human, FDA-approved Phase 1 clinical trial of an injectable hydrogel that aims to repair damage and restore cardiac function in heart failure patients who previously suffered a heart attack.
A research team from the University of Georgia’s Regenerative Bioscience Center has found that a compound molecule used for drug delivery of insulin could be used to treat glioblastoma, an aggressive, usually fatal form of brain cancer.
Methotrexate and the more expensive mycophenolate mofetil performed similarly in a head-to-head clinical trial that compared the two drugs for treating noninfectious uveitis
A new drug discovered through a research collaboration between the University at Buffalo and Tetra Therapeutics may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease.
In this newly published paper authors Hui Li, Ph.D., and Pak King Wong, Ph.D., (The Pennsylvania State University, PA, USA), Michael Morowitz, Ph.D., (University of Pittsburgh, PA, USA) and Neal Thomas, Ph.D., (Penn State University, PA, USA) describe their development of a novel technology approach designed to help clinicians better manage bacterial infection diagnosis and treatment, reduce the improper use of antibiotics and limit the spread of drug-resistant organisms.
Nearly all babies born prematurely receive antibiotics. A new study from Washington University School of Medicine in St. Louis suggests that such early antibiotic treatment could have long-lasting and potentially harmful effects on the gut microbiome.
In honor of Women in Medicine month, we present a sample listing of women leaders in regional anesthesia. This article originally appeared in the February 2016 edition of ASRA News and again in the ASRA Blog three years ago.
Based on the chemical behavior of natural viruses, researchers from the Technion and National Taiwan University have developed hollow nanometric balls that are expected to be used for drug delivery and safe immunizations.
Patients found unconscious after a prolonged period of time – typically due to opioid overdose – are at risk of developing a serious complication called compartment syndrome, reports a study in the September 4, 2019 issue of The Journal of Bone & Joint Surgery.
In recent years, several states have enacted legislation to hold pharmacy benefit managers accountable and crack down on secretive practices that drive up costs for consumers.
Henry Ford Innovations (HFI) has signed an exclusive licensing agreement with a Detroit software and health care company to market an innovative software application that will be appealing to specialty pharmacies worldwide.
A University of Florida microbiologist's latest research found that disease-causing bacteria are competing with their human hosts for a key micronutrient.
Researchers at Vanderbilt University Medical Center (VUMC) are partnering with the Dutch biopharmaceutical firm Batavia Biosciences and Nashville-based IDBiologics to bring to the clinic a highly potent Zika virus neutralizing antibody they isolated three years ago.
AMP has published a new position statement for pharmacogenomic testing. Based on a recent assessment of the current market landscape, the statement includes a list of criteria for laboratories to follow for these types of tests to ensure responsible use, preserve broad access and improve patient care.
CARB-X, an international funder of efforts to fight antimicrobial resistance, is awarding up to $15 million to develop a strep throat vaccine based on original research at UC San Diego.
A drug developed by researchers at the Renaissance School of Medicine at Stony Brook University that targets enzymes involved in the development of pancreatic cancer cells is showing promise for improved treatment of metastatic pancreatic cancer.
Analysis of calls to poison control centers by people misusing or abusing amphetamines, usually prescribed for ADHD, via IV injection, nasal or oral routes also links non-medical use to increased risk of admission to critical care units, attempted suicide and death.
Finding May Create Opportunity to Test Patients to Avoid Ineffective Drugs
An Oklahoma judge ordered Johnson & Johnson to pay $572 million for its role in the opioid crisis in a historic ruling Aug. 26. A federal case in Ohio involves at least 1,600 lawsuits from cities and counties throughout the country. Oxycontin maker Purdue Pharma has offered to settle more than 2,000 lawsuits from states and cities for between $10 billion and $12 billion.
As the opioid tramadol has grown in popularity so too have documented cases of adverse effects. In a new study, researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego show that patients who take tramadol are at greater risk for hypoglycemia, abnormally low blood sugar.
KPMG’s Clinical Intelligence (KCI) platform is helping clinicians improve the quality of care by furnishing them with pharmacogenomics data – information about how genes interact with medicines – from Coriell Life Sciences (CLS), supported by Thermo Fisher Scientific’s leading genetic analysis platform and content.
Buprenorphine and naltrexone can help break a person’s addiction to life-threatening opioid use disorder, but they can be hard for front-line, primary care providers to prescribe, according to researchers at McGovern Medical School at The University of Texas Health Science Center (UTHealth).
In a decade, Medicare recipients saw a sevenfold increase in out of pocket costs for multiple sclerosis drugs. Spending on these drugs by Medicare itself increased by tenfold.
New, more effective antibiotics are being prescribed in only about a quarter of infections by carbapenem-resistant Enterobacteriaceae (CRE), a family of the world’s most intractable drug-resistant bacteria.
Using the largest database of real-time recordings of the effects of common and commercially available cannabis products in the United States (U.S.)
In September’s SLAS Discovery cover article, “Using Physicochemical Measurements to Influence Better Compound Design,” authors Robert J. Young, Ph.D., Shenaz B. Bunally, Ph.D., and Chris N. Luscombe, Ph.D., (GlaxoSmithKline) outline commonly used physiochemical properties and how they are assessed and measured throughout the drug discovery process, while also explaining the implications of each property that have led to flawed results.
Rutgers and other scientists have discovered how brown fat, also known as brown adipose tissue, may help protect against obesity and diabetes. Their study in the journal Nature adds to our knowledge about the role of brown fat in human health and could lead to new medications for treating obesity and type 2 diabetes.
In an extensive “data mining” analysis of British medical records, researchers at the Johns Hopkins Kimmel Cancer Center conclude that taking even a single course of antibiotics might boost—albeit slightly—the risk of developing colon cancer—but not rectal cancer—a decade later. The findings, reported in the August 20 issue of the journal Gut, highlight the need for judicious use of this broad category of drugs, which are frequently improperly or overprescribed, the report authors say.
Each year there are more than 200 million cases of malaria worldwide, a mosquito-borne disease caused by a parasite that brings on fever and body aches and, in some cases, more serious conditions such as coma and death. While the vast majority of these cases occur in sub-Saharan Africa and South Asia, the U.S. each year sees more than 1,500 cases, and currently there is limited access to an intravenously-administered (IV) drug needed for the more serious cases, according to a top malaria researcher at the University of Maryland School Medicine (UMSOM).
Saint Louis University pain researchers will investigate a promising but little understood pain signaling pathway in the hopes of opening up a new avenue for pain medication research.
ISPOR, the professional society for health economics and outcomes research, announced plans for its ISPOR Summit 2019 scheduled for October 11, 2019 in Baltimore, MD, USA.
In small, community hospitals that don’t have resources for a dedicated staff to oversee the proper use of antibiotics, turning to staff pharmacists showed promise in a model study conducted by Duke Health.
Higher levels of blood high-density lipoprotein (HDL) — or good cholesterol — may improve fatigue in multiple sclerosis patients, according to a new University at Buffalo-led study.
A study led by researchers from the University of Illinois at Chicago has found that combining acyclovir — a commonly prescribed topical herpes medication — with particles of activated carbon improves efficacy of the drug. This new approach allows for less frequent dosing and overall course of treatment while providing some protection from infection by the virus as well, opening up the possibility of using the combination in prophylactic products.
Roswell Park researchers have uncovered a biomarker that may help explain why some patients respond better than others to sorafenib, a chemotherapy commonly prescribed for patients with advanced liver cancer.
The human heart’s energy needs and functions are difficult to reproduce in other animals; one new system looks to circumvent these issues and provide a functional view of how different treatments can help ailing cells in the heart following oxygen and nutrient deprivations. Researchers have unveiled a new silicon chip that holds human lab-grown heart muscle cells for assessing the effectiveness of new drugs. They discuss their work in this week’s APL Bioengineering.
Indiana University data scientists have found evidence that women and older adults are more likely to be prescribed multiple drugs that interact dangerously.
Rutgers researchers present an unprecedented exploration of cultural factors concerning Chinese Americans' health in a special edition of the Journal of the American Geriatrics Society (JAGS). Seventeen research papers study elder abuse, cognitive function, psychological well-being, social relationships, and health behaviors among more than 3,000 Chinese Americans aged 60 and older.
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