A biomedical engineer at Washington University in St. Louis is developing a therapeutic option that would prevent opiates from crossing the blood-brain barrier, preventing the high abusers seek.
A synthetic DNA structure was used as bait to capture nuclear proteins, revealing previously unknown role of HNRNPD in the cellular response to DNA damage.
The Jefferson College of Pharmacy has announced a new master’s degree in Population Health Pharmacy. One of the first of its kind, the Master’s in Population Health Pharmacy focuses on the impact of health determinants on outcomes associated with medication use.
The first arm of a phase II clinical trial by a research team at Georgetown University Medical Center testing the use of nilotinib in patients with Parkinson’s disease demonstrates precisely how the agent increases levels of dopamine in the brains of study participants.
There is no such thing as TMI (too much information) when it comes to communicating facts about your health with your physician anesthesiologist before surgery or a medical procedure. You might not think taking ginkgo biloba for memory, using medical marijuana for pain, smoking or snoring are relevant, but these supplements, drugs and conditions are among the eight things you should disclose for your own safety, notes the American Society of Anesthesiologists (ASA).
Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin. Routine testing for this gene could improve patient safety and reduce unnecessary avoidance of other antibiotics, they reported in the Journal of Allergy and Clinical Immunology.
An international panel of the foremost researchers on infectious disease and antimicrobials has formed new guidelines on the use of polymyxins, a class of antibiotics employed as a last resort to treat deadly, drug-resistant bacteria.
• In a phase 3 clinical trial, tenapanor significantly lowered elevated blood phosphate in patients receiving maintenance hemodialysis, resulting in an average reduction of 1.0–1.2 mg/dL over 8 weeks. • Side effects were largely limited to softening of stool and more frequent bowel movements.
Antibiotics survival mechanism: UC San Diego researchers have discovered an unexpected mechanism that allows bacteria to defend themselves against antibiotics, a surprise finding that could lead to retooled drugs to treat infectious diseases.
Researchers at The Wistar Institute have created a drug candidate for cancers associated with Epstein-Barr Virus (EBV), the virus that causes infectious mononucleosis.
Two older drugs, designed for other purposes, produced promising results in the treatment of mice with triple negative breast cancer.
A new, first-of-its kind project from researchers at The University of Kansas Cancer Center aims to boost participation in urologic cancer clinical trials by partnering with community urologists.
Papers on nuclear receptor function in zebrafish; and whether PCB 95 and dendritic arborization effects are sex-dependent are featured in latest issue of Toxicological Sciences.
A team of researchers from the Department of Energy’s Oak Ridge National Laboratory (ORNL) Health Data Sciences Institute (HDSI) have harnessed the power of artificial intelligence (AI) to better match cancer patients with clinical trials. The researchers were one of ten teams to develop a digital tool to address complex challenges relevant to medical conditions such as cancer and Lyme disease as part of The Opportunity Project (TOP) Health Sprint, a 14-week effort sponsored by the Census Bureau, coordinated by the Department of Health and Human Services, and led by two Presidential Innovation Fellows.
Chemists in Vienna find a method to replace hydrogen with fluorine in organic moleculesThe development and improvement of pharmaceuticals plays the central role in the ongoing battle against human disease. Organic synthesis is the field that enables these developments as it offers the toolbox to diversify chemical structures.
As many as 50% of children with epilepsy and 20% of adults carry an ADHD diagnosis. Package inserts for ADHD medications warn of the drugs’ potential to lower the seizure threshold. However, there are few empirical data on the risk of seizures at therapeutic doses.
Cognitive impairment affects more than 50 million people worldwide. In the United States alone, one in three seniors dies with some type of dementia. This creates a critical clinical need for safe and effective therapies for the treatment and prevention of cognitive impairment.
Medical practitioners commonly treat organs in isolation, but Boston University physicist Plamen Ivanov wants to usher in a new paradigm. As he will describe at the 2019 APS March Meeting, “It’s time to view health and disease not only from the perspective of individual organs but from the point of view of their integration,” he said. “We need to show how the different systems communicate with each other and stay in sync.” Ivanov calls the field he’s pioneering “network physiology.”
Vaccinations are the world’s frontline defence against infectious diseases yet despite decades of interventions, unsafe injection practices continue to expose billions of people to serious infection and disease. Now, new technology from the University of South Australia is revolutionising safe vaccination practices through antibacterial, silver-loaded dissolvable microneedle patches, which not only sterilise the injection site to inhibit the growth of bacteria, but also physically dissolve after administration.
Pharmaceutical leader Cam Garner and his wife Wanda, a cancer workshop facilitator and philanthropic fundraiser, gave UC San Diego $2 million to establish the Garner Family Chancellor’s Endowed Chair in Blood and Marrow Transplant.
Announcement of the new Oxford-Harrington Rare Disease Centre to deliver new treatments for rare diseases.
• Payments by organ transplant recipients and Medicare decreased significantly following the introduction of generic immunosuppressive medications. • Large differences in out-of-pocket payments for immunosuppressive medications between Part D beneficiaries who did and did not qualify for the Medicare low-income subsidy suggest that recipients with resources just above the threshold to qualify for the subsidy may experience considerable financial strain.
Researchers at UC San Diego School of Medicine have identified a clear group of characteristics that predict heightened risk for experiencing increased anxiety or worsening of mood that interferes with daily activities when using a smoking cessation drug. Results are published in the February 27 online edition of the Journal of General Internal Medicine.
Blocking two molecular pathways that send signals inside cancer cells could stave off esophageal adenocarcinoma (EAC), the most common esophageal malignancy in the United States, according to new research out of Case Western Reserve University School of Medicine.
Researchers from the McKelvey School of Engineering and Washington University School of Medicine in St. Louis are one step closer to delivering precise amounts of medication to exact location, repurposing an existing imaging "painting" method.
Having a family member with persistent opioid use may be a risk factor for young adults continuing prescriptions long after their own surgeries, a new Michigan Medicine study suggests.
Medically high-risk patients and communication breakdowns between providers contribute to the difficulty of medication management for older adults receiving home health care, finds a study led by researchers at NYU Rory Meyers College of Nursing.
A new way to create proteins that can sneak through HIV’s protective coating may be a step toward understanding the key components needed for developing a vaccine for the virus, according to researchers.
Infants exposed to antenatal corticosteroid therapy (ACT) to accelerate lung maturation have a clinically significant reduction in birth size, according to a new of study of 278,508 births published this week in PLOS Medicine by Alina Rodriguez of the University of Lincoln and Imperial College London, UK, and colleagues.
New preclinical findings from extensive cell and animal studies suggest that cysteamine bitartrate, a drug already used for a rare kidney disease, could benefit patients with some mitochondrial disorders. No proven effective treatments yet exist for these complex conditions with severe energy deficiency
The American Society of Anesthesiologists (ASA) and the Arkansas Society of Anesthesiologists (ARSA) strongly oppose SB 184 and HB 1283, which will dismantle the anesthesia care team model in Arkansas by allowing nurse anesthetists to administer anesthesia without physician supervision. HB 1283 will also allow nurse anesthetists to provide analgesics, opening the door for nurses to provide powerful pain-relieving drugs such as opioids.
Nonprofit Clinical Research Pathways announces two new members of its Board of Directors, from the Atlanta area
In a recent Rutgers study, 38 percent of patients discharged from the emergency department had at least one drug interaction resulting from a newly prescribed medicine.
FINDINGS Researchers found that more than 97 percent of the surgeries for appendicitis were laparoscopic, or minimally invasive, and most patients were discharged the same day or the next day. Only 3 percent of the procedures resulted in complications. Rates of unnecessary surgery — removing a “normal” appendix — were low (less than 4 percent), but were much higher in people without imaging studies before their operation (nearly 20 percent).
Healthcare providers depend on lab test results to help them diagnose and determine the most effective treatments for children—especially when treating children who are too young to communicate their symptoms. Join AACC and leading experts in laboratory medicine for a discussion about the need to develop precise pediatric reference intervals to improve lab testing for children, and the challenges that must be overcome before this can be accomplished.
Nine out of 10 people who believe they’re allergic to the antibiotic either aren’t allergic or have only some intolerance, and eight of 10 people who had an allergic reaction to penicillin 10 or more years ago will now be fine.
Scientists at the microbiology lab led by Javier Campos-Gómez, Ph.D., in Drug Discovery at Southern Research discovered that Pseudomonas aeruginosa, a bacterium responsible for severe, drug-resistant infections in humans, uses a family of fatty acids, known as “oxylipins,” in a cell-to-cell signaling language critical for its virulence.
A new study by Johns Hopkins Bloomberg School of Public Health researchers found that U.S.-based patient advocacy organizations received a disproportionate amount of contributions made by the world’s 10 largest pharmaceutical companies in 2016.
Assessment of Changes in the Geographical Distribution of Opioid-Related Mortality Across the United States by Opioid Type, 1999-2016
The first clinical study investigating the use of the direct oral anticoagulant, rivaroxaban, to prevent blood clots in patients with cancer at high-risk published today in the New England Journal of Medicine. The study found no significant reduction in venous thromboembolism or death in the overall 180-day trial period; however, the researchers did observe a lower incidence of these events while patients were actively on the study drug, or during the on-treatment period.
Public health experts and policymakers will gather at the Johns Hopkins Bloomberg School of Public Health on Monday, February 25 to discuss policies that could reduce maternal deaths in the United States, especially among black women. The event will also honor Dr. Shalon Irving, a Johns Hopkins Bloomberg School of Public Health alumna and Centers for Disease Control and Prevention (CDC) epidemiologist who passed away unexpectedly in 2017, just three weeks after giving birth.
In a strategic search, Johns Hopkins scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke.
New medical evidence shows improved mechanical fixation with a novel inset shoulder implant that minimizes surgical complications and may increase the longevity of artificial shoulder replacements. This new study in the Journal of Shoulder and Elbow Surgery demonstrates, for the first time, successful long-term results with a promising new technology that is gaining attention of shoulder surgeons.
As part of nationwide efforts to improve emergency medical care, researchers at the Mount Sinai Health System, in collaboration with UC San Diego Health, have released a national framework report titled “Promoting Innovations in Emergency Medical Services” that identifies regulatory, financial, and technological obstacles to improving local and state EMS systems.
Findings in Journal of the National Cancer Institute shows patients don’t have enough opportunities for participation
Renowned scientists including Nobel laureates, research pioneers and celebrated educators will convene at the Experimental Biology (EB) 2019 meeting, to be held April 6–9 in Orlando. Bringing together more than 12,000 life scientists in one interdisciplinary community, EB showcases the latest advances in anatomy, biochemistry, molecular biology, investigative pathology, pharmacology and physiology.
Patients taking diuretics are often at risk for low potassium levels, which can put patients at an increased risk of death from cardiac arrhythmias or other causes. But researchers from the Perelman School of Medicine at the University of Pennsylvania found that taking prescription potassium supplements can reduce these patients’ risk by nearly 10 percent as daily outdoor temperatures increase—a time when patients may be at highest risk due to loss of potassium while sweating. These findings are detailed in a study published today in BMJ Open.
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