New 12-month data from the Smidt Heart Institute at Cedars-Sinai backs up an earlier study proving that a pharmacist-led, barbershop-based medical intervention can successfully lower blood pressure in high-risk African-American men. The follow-up research was published Dec. 17, 2018, in the journal Circulation.
Interactions with water dominate how drug molecules bind to targets, but it’s tricky to model these interactions, limiting the accuracy of drug design. In a recent paper in The Journal of Chemical Physics, William A. Goddard III and Saber Naserifar from the California Institute of Technology describe their novel approach to building a new description of water (known as a force field) and demonstrate its accuracy.
When improved antidepressants hit the market in the 1980s, heavy drinking among people with depression dropped 22 percent, suggesting people who knowingly use drugs and alcohol to relieve mental and physical pain will switch to safer, better treatment options when they can get them,
UT Southwestern researchers have succeeded in neutralizing what they believe is a primary factor in late-onset Alzheimer’s disease, opening the door to development of a drug that could be administered before age 40, and taken for life, to potentially prevent the disease in 50 to 80 percent of at-risk adults.
The U.S. Department of Energy has approved the technical scope, cost estimate and plan of work for an upgrade of the Advanced Photon Source, a major storage-ring X-ray source at Argonne.
People newly diagnosed with cancer, particularly blood cancers, and those treated with chemotherapy have a greater risk of developing shingles, according to a new study in the Journal of Infectious Diseases. The findings may help guide efforts to prevent the often painful skin condition in cancer patients through the use of new vaccines. The large prospective study expands on previous research by examining the risk of shingles before and after a new cancer diagnosis and across a range of cancer types among approximately 240,000 adults in Australia from 2006 to 2015.
A team from the GW School of Medicine and Health Sciences found emerging treatments, such as neurokinin-1 receptor antagonists, were the most promising against prurigo nodularis.
Researchers at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago, and colleagues, used a blood test and microarray technology to identify distinct molecular signatures in children with cystic fibrosis. These patterns of gene expression ultimately could help predict disease severity and treatment response, and lead to therapies tailored to each patient’s precise biology.
Conventional math cannot adequately model the interaction of multiple genes over multiple time frames – a necessary foundation for any cancer-fighting drugs. The study, published in “Frontiers in Physiology” by Mahboobeh Ghorbani, Edmond Jonckheere and Paul Bogdan of the Ming Hsieh Department of Electrical Engineering, is the first study that accounts for the memory, cross-dependence and fractality of gene expression
While friends or family members may feel helpless if someone they know suffers from addiction, one UAB physician says hope can start at home.
Dr. Matthias von Herrath, M.D., who founded the Type 1 Diabetes Center at La Jolla Institute for Immunology (LJI) has been identified as the world’s top expert in Type 1 Diabetes by Expertscape, an organization that provides tools to quickly and easily find the best clinicians or pioneering scientists specializing in a wide range of medical conditions or biomedical topics.
Value in Health, the official journal of ISPOR, announced today the publication of new research showing that the lowest priced generic drugs are at a substantially elevated risk of experiencing a drug shortage, and that periods of drug shortages are associated with only modest increases in drug prices.
Researchers from the Virginia Tech School of Neuroscience are teaming with the University of California San Diego and the U.S. National Institutes of Health to develop a drug –- now in its earliest stages -– that can treat certain types of chronic pain without the addictive consequences of opioids.
Value in Health announced the publication of new research showing that the Diabetes Medication System Rating Questionnaire and the Diabetes Medication System Rating Questionnaire-Short Form are the preferred survey instruments for measuring medication satisfaction in patients with type 2 diabetes using oral therapy in clinical trials.
The new Sherman Institute will advance basic research on novel therapies for a range of disorders, including autoimmune, neurodegenerative, and infectious diseases, as well as cancer.
When households in sub-Saharan Africa don’t have an adequate number of insecticide-treated bed nets, pregnant women and children under five are the most likely family members to sleep under the ones they have, leaving men and school-aged children more exposed to malaria, new Johns Hopkins Center for Communication Programs (CCP) research suggests.
Why do orally-administered drugs for diabetes work for some people but not others? According to researchers at Wake Forest School of Medicine, bacteria that make up the gut microbiome may be the culprit.
According to a study published today, John D’Auria and his colleagues report that, by discovering the genes and enzymes plants use to form the second ring in tropane alkaloids’ core structure, they will be able to develop new, novel ways to produce these important chemicals.
The Society for Healthcare Epidemiology of America has issued a new expert guidance on how hospitals and healthcare providers may reduce infections associated with anesthesiology procedures and equipment in the operating room.
A study finds that palbociclib, in combination with endocrine therapy, improves progression free survival
For people with Type 2 diabetes, testing blood sugar levels becomes part of everyday life. But a new study suggests that some of them test more often than they need to. Fourteen percent of people with Type 2 diabetes who don’t require insulin are buying enough test strips to test their blood sugar two or more times a day – when they don’t need to test nearly that frequently according to medical guidelines.
This week, SHRO partners with the Italian Movie Award International Film Festival to support Italian-American work in cinema, particularly in recognition for accomplishments with the use of Virtual Reality (VR) in applications in medicine
A team from the GW School of Medicine and Health Sciences found many dermatologists are interested in learning more about and recommending therapeutic cannabinoids to their patients.
David Cheresh, Distinguished Professor at University of California San Diego School of Medicine, received $4.2 million National Cancer Institute Outstanding Investigator Award to continue his research into cancer’s ability to overcome stress, gain drug resistance and metastasize.
Pain after surgery can be effectively managed with minimal or no opioids, according to research conducted at Roswell Park Comprehensive Cancer Center and published today in JAMA Network Open. A two-year study by a multidisciplinary team of surgeons and other cancer specialists shows that the amount of opioid medications prescribed after surgery can be drastically reduced without negatively affecting pain scores, postoperative complications or patient requests for additional
Researchers spent two years testing chemical compounds for their ability to inhibit the malaria parasite at an earlier stage in its lifecycle than most current drugs, revealing a new set of chemical starting points for the first drugs to prevent malaria instead of just treating the symptoms.
A new study could help states that will soon expand Medicaid, or may add a work requirement, understand what might be in store. Nearly half of enrollees in Michigan’s expanded Medicaid felt their physical health improved; more than a third cited better mental or dental health. Over two-thirds of those with jobs said coverage helped them do better at work.
Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain—or tuberculosis meningitis (TBM)—is often deadly, always hard to treat, and a particular threat to young children.
Heather Gornik, MD, has been named co-director of the Vascular Center at University Hospitals Harrington Heart & Vascular Institute.
Exposure to emerging contaminants, even at extremely low doses, can cause adverse health effects for humans, including endocrine disruption which can lead to developmental malformations, interference with reproduction, increased cancer risk and disturbances in the immune and nervous system functions. These emerging contaminants include pharmaceuticals and personal care products, hormones, perfluorinated alkyls and volatile organics, and they may pose a threat to both the environment and human health.
Os investigadores da Mayo Clinic constataram que um medicamento oral, apixabana, utilizado para tratar a formação de coágulos de sangue em pacientes submetidos a terapia contra o câncer, é seguro e eficaz. O medicamento foi associado a uma menor quantidade de complicações hemorrágicas e menos formação recorrente de coágulos sanguíneos, em comparação com a heparina de baixo peso molecular. Os resultados foram apresentadas na assembleia anual da Sociedade Americana de Hematologia por Robert McBane II M.D., um cardiologista da Mayo Clinic.
Cardiovascular patients at risk for gastrointestinal bleeding from taking oral anticoagulants like warfarin reduce that risk by 34 percent when taking a proton pump inhibitor (PPI) in combination, according to a Vanderbilt University Medical Center study published in JAMA.
Investigadores da Mayo Clinic desenvolveram duas novas estratégias que podem melhorar o desempenho da terapia do receptor de antígeno quimérico (terapia com células T CAR) no tratamento do câncer. Eles apresentarão os resultados de suas pesquisas pré-clínicas na assembleia anual de 2018 da Sociedade Americana de Hematologia em San Diego, EUA.
Researchers at The Wistar Institute have developed novel synthetic DNA-encoded monoclonal antibodies (DMAbs) directed against PCSK9, a protein key to regulating cholesterol levels in the bloodstream.
Meticulous new research from the School of Medicine has changed a well-accepted scientific belief about neurons, the vital nerve cells that allow us to experience the world and record those experiences as memories in our brains.
As 2018 draws to a close, the pharmaceutical industry is celebrating a prosperous year of new investments and therapeutic breakthroughs. These successes were driven by cutting-edge science and progress in finally translating long-standing technology into actual products, according to a cover story in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society.
It is an often case that one’s health and life depend on as quick a disease is found. That is why today the ways of quick and effective revealing of a disease is one of the most important directions in medicine.
Two-Thirds of Women Did Not Receive Their Desired Contraception at the Six-Week Postpartum Visit, Increasing Risk of Unintended Pregnancy.
Carson Bruns is working to put body art to use, designing high-tech inks that may one day signal your temperature or changes in blood chemistry.
Researchers at the University of Maryland School of Medicine’s (UMSOM) Maryland Psychiatric Center (MPRC) and Institute for Genome Sciences (IGS), along with researchers at the University of Maryland School of Pharmacy (UMSOP), have been awarded a collaborative five-year $1.78 million grant to study the brain-to-gut connection in schizophrenia
Precision medicine will extend beyond prediction, diagnosis and treatment of disease to also include broader health initiatives, including prevention, nutrition and wellness. These new procedures raise novel legal, policy and ethical issues.
The American Society of Anesthesiologists (ASA) commends the Trump Administration for its report released today by the U.S. Dept. of Health and Human Services (HHS) that reinforces the importance of scope of practice (SOP) laws and regulations, which can protect patients at risk when a complex, technically demanding medical procedure, such as surgery and anesthesia, are performed.
In a small study of infrequent cannabis users, Johns Hopkins Medicine researchers have shown that, compared with smoking cannabis, vaping it increased the rate of short-term anxiety, paranoia, memory loss and distraction when doses were the same.
Researchers at Moffitt Cancer Center are trying to devise alternative mechanisms to block KRas. Their recent study demonstrates that the protein GSK3 is an important mediator of KRas-dependent tumor viability. Their research was published today in Nature Communications.
Cleveland Clinic medical oncologist and researcher, Alok Khorana, M.D., is the primary investigator on a study that concluded rivaroxaban for venous thromboembolism (VTE), a blood clot in the venous system, significantly reduced VTE and VTE-related death for outpatient, at-risk cancer patients while they were taking the oral blood thinner. During the on-treatment period, blood clots occurred less frequently (2.62 percent) in patients taking rivaroxaban, compared to and 6.41 percent of the placebo groups. However, during the full study period – which included 180-day observation after the medication was stopped ¬– the gap narrowed with blood clots occurring in 5.95 percent of patients in the rivaroxaban group, compared to 8.79 percent of the placebo groups.
In lab and mouse experiments, UC San Diego School of Medicine researchers developed a method to leverage B cells to manufacture and secrete tumor-suppressing microRNAs.
In a new study published in the Journal of Clinical Oncology, Manuel Hidalgo, MD, PhD, and colleagues conducted a phase I/II trial designed to evaluate the efficacy and safety of nab-paclitaxel given in combination with gemcitabine in patients with pancreatic cancer and reduced health status. The team – based at the Centro Nacional de Investigaciones Oncologicas (Spanish National Cancer Center), where Hidalgo previously served as Director of the Clinical Research Program and Vice Director of Translational Research – reported that the combination of therapies significantly improved survival even in less robust patients with metastatic pancreatic ductal adenocarcinoma (PDAC) compared to gemcitabine alone.
Perosphere Pharmaceuticals Inc. today announced the presentation of clinical study results demonstrating, "Ciraparantag Safely and Effectively Reverses Apixaban and Rivaroxaban in Age-matched Healthy Volunteers as Measured by Whole Blood Clotting Time," at the American Society of Hematology (ASH) annual meeting in San Diego on Monday, December 3, 2018.
Nursing and pharmacy researchers hope to find a replacement for prednisone with fewer and less-severe side effects.
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