A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential

Newswise — Repair of the tendon enthesis (e.g., after a rotator cuff tear) is a clinical challenge. To motivate novel cell-based treatment strategies for enthesis repair, Fang et al. define enthesis cell transcriptomes and differentiation trajectories. A unique enthesis Gli1+ progenitor population is identified and delivered to injured entheses to enhance healing.