Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease

Newswise — The process of generating adult-born neurons (ABNs) in the hippocampus is impaired in AD. Song and colleagues report a circuit-based strategy by stimulating SuM to enhance hippocampal neurogenesis in AD mice. Activation of SuM-modified ABNs restores cognitive and affective function along with improved hippocampal plasticity and microglia dynamics.