Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

Li et al. demonstrate that amino acid catabolism and the GCN2-eIF2α axis control protein synthesis and energy production in hematopoietic stem cells for maintenance and proliferation. They also show that nicotinamide riboside increases amino acid catabolism and activates the GCN2-eIF2α axis to sustain the long-term function of hematopoietic stem cells.