BMAL1 Circadian Clock Protein Plays Role in Diet-induced High Blood Pressure in Male Mice

Article title: Male kidney-specific BMAL1 knockout mice are protected from K+-deficient, high-salt diet-induced blood pressure increases

Authors: G. Ryan Crislip, Hannah M. Costello, Alexandria Juffre, Kit-Yan Cheng, I. Jeanette Lynch, Jermaine G. Johnston, Charles B. Drucker, Phillip Bratanatawira, Annanya Agarwal, Victor M. Mendez, Ryanne S. Thelwell, Lauren G. Douma, Charles S. Wingo, Abdel A. Alli, Yogesh M. Scindia, Michelle L. Gumz

From the authors: “We show here, for the first time, that kidney-specific BMAL1 knockout mice are protected from blood pressure increases and immune responses to a salt-sensitive diet.”

This study is highlighted as one of November’s “best of the best” as part of the American Physiological Society's APSselect program.