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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 23-Oct-2014 5:00 PM EDT

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Blood Test Helps Predict Relapse in Patients with Autoimmune Disease Affecting the Kidneys

• Among patients with an autoimmune disease called ANCA-associated vasculitis, autoantibody increases were linked with an 11-fold increased risk of relapse in patients whose kidneys were affected. • Among patients without kidney involvement, such increases were associated only weakly with relapses.

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Recent Kidney Policy Changes Have Not Created Racial Disparities in Care

• After the implementation of a new payment system for kidney failure care and changes to dosing guidelines for anemia drugs, there were no meaningful differences by race regarding changes in management practices or laboratory measures among dialysis patients.

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Exercise Linked with Improved Physical and Mental Health Among Dialysis Patients

• Among dialysis patients, aerobic activity was linked positively with health-related quality of life and inversely with depressive symptoms and premature death. • In general, patients had higher aerobic activity levels if they were treated in dialysis clinics offering exercise programs.

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Blood Tests Predict Kidney Disease Patients’ Risk of Developing Heart Failure

• Kidney disease patients with detectable levels of a blood protein called high-sensitivity troponin T had up to a 5-fold increased risk of developing heart failure. • Those with high levels of a protein called N-terminal pro-B-type natriuretic peptide had a nearly 10-fold increased risk of developing heart failure.

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Predictor of Tissue Injury in Kidney Transplant Recipients Found

Researchers at UC San Francisco and Rush University Medical Center, Chicago, may have found a predictor for a disorder affecting kidney transplant recipients that can accelerate organ failure, a discovery that eventually could allow for customized therapies and improved patient selection for transplant.

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Mysterious Balkan Disease’s Likeliest Risk Factor Also in Chinese Medicines

Scientists speculate that the highest risk factor for a kidney disease common to five Balkan nations is a plant commonly used in various Chinese herbal medicines.

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Cooling of Dialysis Fluids Protects Against Brain Damage

• Dialysis drives progressive white matter brain injury due to blood pressure instability; however, patients who dialyzed at 0.5◦C below body temperature were completely protected against such white matter changes.

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Many Kidney Failure Patients Have Concerns About Pursuing Kidney Transplantation

• Among new dialysis patients, the most frequently cited concerns were that patients felt they were doing fine on dialysis and felt uncomfortable asking someone to donate a kidney. • Older age was linked with having high health-related or psychosocial concerns, as was being a woman, being less educated, and having more comorbid illnesses. • Patients having such concerns had less than half the chance of getting listed for a transplant than those without them.

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Keryx Biopharmaceuticals Receives FDA Approval of Ferric Citrate

Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") today announced that the U.S. Food and Drug Administration (FDA) approved Ferric Citrate (formerly known as Zerenex) for the control of serum phosphorus levels in patients with chronic kidney disease (CKD) on dialysis.

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