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Older Kidney Donors with Hypertension May Have Good Kidney Health Following Donation

Kidney donors with hypertension had slightly fewer nephrons (the kidney’s filtering units) at the time of donation than similarly aged donors with normal blood pressure; however, 6 months following their surgery, hypertensive and non-hypertensive donors both maintained excellent blood pressure control and had similarly robust compensatory kidney responses.

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Taming the Inflammatory Response in Kidney Dialysis

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Frequent kidney dialysis can cause systemic inflammation, leading to complications such as cardiovascular disease and anemia by triggering the complement cascade, part of the innate immune system. Complement is inadvertently activated by modern polymer-based dialysis blood filters. New work has found an effective way to avoid these problems by temporarily suppressing complement during dialysis.

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Drug May Help Prevent Bone Fractures in Patients on Dialysis

• In patients on dialysis, cinacalcet reduced the rate of bone fracture by 16% to 29%, after accounting for patient characteristics and other factors.

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Low Levels of Circulating Protein Linked with Heart Problems in Mice with Kidney Disease

• Decreased blood levels of a protein called Klotho increases the risk of heart disease in mice with chronic kidney disease. • If confirmed in humans, increasing Klotho levels may help protect the hearts of patients with chronic kidney disease.

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Simple Model Predicts Progression of Kidney Disease Among Socially Disadvantaged Patients

• A simple model using 5 commonly available variables from electronic health records adequately discriminates between socially disadvantaged individuals with chronic kidney disease who will and will not progress to kidney failure.

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Penn Study Points to New Therapeutic Strategy in Chronic Kidney Disease

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Chronic kidney disease affects at least one in four Americans who are older than 60 and can significantly shorten lifespan. Yet the few available drugs for CKD can only modestly delay the disease’s progress towards kidney failure. Now, a team has found an aspect of CKD’s development that points to a promising new therapeutic strategy.

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Pilot Studies Find New Drug Could Help Reduce Dietary Phosphorus Absorption

Researchers presented two preliminary studies at ASN Kidney Week 2014 in Philadelphia, PA, that demonstrate the potential of a small-molecule inhibitor of NHE3 to help reduce phosphorus absorption in patients with kidney disease. Patients with reduced kidney function are unable to maintain normal levels of phosphorus, which can lead to hyperphosphatemia.

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New Therapeutic Strategy for Chronic Kidney Disease

Chronic kidney disease (CKD) affects at least one in four Americans who are older than 60 and can significantly shorten lifespan. Yet the few available drugs for CKD can only modestly delay the disease’s progress towards kidney failure. Now, a team has found an aspect of CKD’s development that points to a promising new therapeutic strategy.

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Researchers Identify Genetic Markers That May Predispose Individuals for Kidney Injury

Researchers have identified genetic markers that may help to identify individuals at risk for acute kidney injury (AKI) in the hospital setting. Presented at ASN Kidney Week 2014 in Philadelphia, PA, the study offers new clues about the development of AKI and could lead to potential therapeutic interventions.

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Investigational Drug Reduces High Potassium Levels in Chronic Kidney Disease Patients

Research published today found that the investigational drug patiromer decreased high potassium levels and maintained normal potassium levels in patients with chronic kidney disease. The results of a multicenter trial appear in the New England Journal of Medicine.

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