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Symposium Focuses on Disparities in Cardiovascular Disease

There's a "critical need" for research and innovative new strategies to address health disparities and to improve health outcomes across all groups of people with cardiovascular disease, according to a special symposium feature in the August issue of The American Journal of Medical Sciences (AJMS), official journal of the Southern Society for Clinical Investigation (SSCI). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 31-Jul-2014 5:00 PM EDT

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Ferric Citrate May Reduce Dialysis Patients’ Need for Multiple Medications

• Ferric citrate effectively reduced blood phosphorus levels while increasing iron stores and decreasing the need for intravenous iron and anemia medications in dialysis patients. • The medication may help reduce complications and costs associated with kidney disease care.

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Genetic Test Helps Predict Which Children with Kidney Disease Will Respond to Standard Therapy

• Among children with sporadic nephrotic syndrome, genetic mutations in the kidney’s filtration barrier were frequently linked with a lack of response to immunosuppressive treatments. • The genetic test was even more predictive than a kidney biopsy for identifying children who would not benefit from immunosuppressive therapies.

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Zerenex™ (Ferric Citrate) Long-Term Phase 3 Study Results Published in the Journal of the American Society of Nephrology

Keryx Biopharmaceuticals, Inc. announced the publication of results from the long-term, randomized, active control Phase 3 study of Zerenex (ferric citrate), the Company's investigational oral ferric iron-based phosphate binder, for the treatment of hyperphosphatemia in patients with end-stage renal disease (ESRD) on dialysis. The PERFECTED study (PhosphatE binding and iRon delivery with FErric CiTrate in EsrD) was published online today in the Journal of the American Society of Nephrology (JASN).

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Cost of Kidney Donation May Be Too Much for Potential Donors with Low Income

• Between 1999 and 2010, lower income regions in the US consistently had lower rates of living donation compared with higher income populations. • The difference in living donation rates between lower and higher income regions was much larger in recent years than it was in the past.

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Cost of Expensive Medication in Dialysis Catheters May Be Offset by Reduced Complications

• The increased cost of an expensive drug that can prevent clots in dialysis catheters may be offset by lower costs for managing complications. • Additional studies are needed to determine the medication’s long-term cost and effectiveness.

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GW Researchers Present Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

Researchers at the George Washington University were published in the New England Journal of Medicine, calling for greater follow-up care for those with acute kidney injury, as these patients often present later in life with chronic kidney disease, and vice versa.

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Risk Factors for Chronic Kidney Disease Are Present Decades Before Diagnosis

• Obesity, high blood pressure, high triglycerides, and diabetes increase a person’s risk of developing chronic kidney disease decades later. • Early identification of such risk factors may help improve efforts to prevent kidney disease.

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Small Changes to US Kidney Allocation Policy May Help Reduce Geographic Disparities in Transplantation

• In Tennessee and Florida, waiting times and other measures of geographic disparity in kidney transplantation became almost equal after the states adopted a Statewide Sharing variance to the national kidney allocation policy in the early 1990s. • Meanwhile, the geographic disparity in kidney transplantation became worse in other comparable states.

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