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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 10-Sep-2015 9:00 AM EDT

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Antibodies in the Blood Provide Clues to Kidney Transplant Recipients’ Likelihood of Rejection

• Among kidney transplant recipients, patients with mostly IgG3 donor-specific HLA antibodies had a higher likelihood of organ rejection soon after transplantation. • If rejection occurred in those with mostly IgG4 antibodies, it was usually much later after transplantation.

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Kidney Impairment Decreases Blood Flow to the Brain, Boosting Risk of Brain Disorders

• In a population-based study, poor kidney function was strongly related to decreased blood flow to the brain. • Poor kidney function was linked to stroke and dementia most strongly in participants with decreased blood flow to the brain.

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Potential New Therapy Approaches to Reverse Kidney Damage Identified

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Study shows that cell plasticity program resulting from kidney damage can be targeted to reverse disease and fibrosis.

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Key Gene Found to Drive Kidney Disease Severity

Patients with higher levels of a key protein are at greater risk for severe kidney disease

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Byproduct of Intestinal Bacteria May Jeopardize Heart Health in Patients with Kidney Disease

• Blood levels of TMAO, a byproduct generated from intestinal bacterial as they metabolize dietary nutrients, progressively increase with advancing severity of kidney disease. • TMAO levels are dramatically reduced when kidney function is restored following kidney transplantation. • High TMAO levels are linked with an increased risk of atherosclerosis and premature death in patients with chronic kidney disease.

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Mild Hypothermia in Deceased Organ Donors Significantly Improves Organ Function in Kidney Transplant Recipients

Mild hypothermia in deceased organ donors significantly reduces delayed graft function in kidney transplant recipients when compared to normal body temperature, according to UCSF researchers and collaborators, a finding that could lead to an increase in the availability of kidneys for transplant.

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Tailored Mobile Health Technologies May Help Patients Take Their Medications Appropriately

• There was only a 5% error rate when patients with chronic kidney disease used mobile health technologies designed to help them use medications appropriately.

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A New Litmus Test for Chaos?

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Researchers from the University of Maryland have come up with a new definition of chaos that applies more broadly than Lyapunov exponents and other previous definitions of chaos. The new definition fits on a few lines, can be easily approximated by numerical methods, and works for a wide variety of chaotic systems.

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Researchers Identify Potential New Targets for Treating Kidney Disease

• Proteins in the Wnt signaling pathway help drive kidney scarring that can lead to chronic kidney disease.

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Researchers Find Key Player in Diabetic Kidney Disease Through Power of Metabolomics

Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease.

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Investigational Drug Prevents Life-Threatening Side Effects of Kidney Disease Treatment

The investigational drug patiromer quickly reduced elevated blood-potassium levels—a common life-threatening side effect of treatment for chronic diabetic kidney disease. In this year-long study of more than 300 patients, patiromer kept potassium levels under control for the length of the trial.

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Drug Provides Improvement for Diabetic Kidney Disease Patients with High Potassium Levels

Among patients with diabetic kidney disease and hyperkalemia (elevated potassium levels in the blood), a potentially life-threatening condition, those who received the new drug patiromer, twice daily for four weeks, had significant decreases in potassium levels which lasted through one year, according to a study in the July 14 issue of JAMA.

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Electrocardiogram Screening May Help Predict Kidney Disease Patients’ Risk of Dying From Heart Disease

• Certain electrocardiogram measures helped investigators identify a subgroup of individuals with chronic kidney disease who had substantially elevated risks of dying from heart disease.

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Blood Test Could Identify Diabetes Decades Before It Develops

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Scientists at the MRC’s Clinical Sciences Centre (CSC) in West London are the first to show that a small molecule circulates in the blood of people who are in the early stages of type 1 diabetes. A simple blood test could detect this biological marker years, maybe decades, before symptoms develop.

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Experts on SCOTUS ACA Ruling, Fewer Side Effects for Breast Cancer Treatment, Glacial Earthquakes, and More Top Stories 26 June 2015

Other topics include resurgence of whales off southern California, treating chronic kidney disease, and a breakthrough in a heart-specific type of stem cell.

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Researchers Outline New Strategies for Combatting Chronic Kidney Disease and Other Long-Term Conditions

Experts have identified new strategies for using electronic health records (EHRs) to treat patients with chronic kidney disease. These recommendations may help clinicians and hospitals better manage individual patients with chronic conditions and identify groups of patients most likely to benefit from different treatment strategies.

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Geography Is Destiny in Deaths from Kidney Failure, Study Shows

The notion that geography often shapes economic and political destiny has long informed the work of economists and political scholars. Now a study led by medical scientists at Johns Hopkins reveals how geography also appears to affect the very survival of people with end-stage kidney disease in need of dialysis.

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More Dialysis Patients Living in Poor Neighborhoods

The percentage of adults beginning kidney dialysis who lived in zip codes with high poverty rates increased from 27.4 percent during the 1995-2004 time period to 34 percent in 2005-2010.

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Vitamin D Supplements May Benefit Children with Kidney Disease

• Among children with chronic kidney disease, those with lower vitamin D levels had higher levels of blood markers related to kidney dysfunction as well as greater kidney function loss over time. • Five-year kidney survival was 75% in patients with vitamin D levels ≥50 nMol/L at the start of the study and 50% in those with lower levels.