In the first such procedures in Tennessee, Vanderbilt University Medical Center has successfully used technology to bring two donor hearts that stopped beating back to life before transplanting them into patients.
Memorial Sloan Kettering Cancer Center (MSK) announces its most recent awards and appointments for the institution’s physicians, scientists, nurses, and staff.
Mount Sinai researchers have discovered a way to enhance the potency of blood-forming stem cells, potentially opening the door to a new approach for bone marrow transplantation.
脂肪组织和骨髓中的间充质基质细胞因具有抗炎特性而被广泛用于各类治疗试验，但Mayo Clinic的一项新研究发现，肝细胞在这方面可能具有更大的潜质。
• Survival after kidney transplantation during childhood has improved over the last 40 years in Australia. • Survival rates improved primality due to decreases in deaths from cardiovascular disease and infection.
As células-tronco mesenquimais do tecido adiposo e da medula óssea são amplamente utilizadas em ensaios terapêuticos por suas propriedades anti-inflamatórias, mas uma nova pesquisa da Mayo Clinic descobriu que as células hepáticas podem ser de maior valor.
ينتشر استخدام الخلايا السَّدَويَّة اللحمية المتوسطية من النسيج الدهني والنخاع العظمي في التجارب العلاجية، وذلك بسبب مزاياها المُضادة للالتهابات، ولكن البحث الحديث في Mayo Clinic اكتشف أن خلايا الكَبِد قد تكون ذات قيمة أكبر.
Mesenchymale Stromazellen aus Fettgewebe und Knochenmark werden wegen ihrer entzündungshemmenden Eigenschaften häufig in therapeutischen Studien eingesetzt, doch neue Forschungsergebnisse von Mayo Clinic zeigen, dass Leberzellen möglicherweise von größerem Nutzen sind.
Les cellules mésenchymateuses stromales provenant du tissu adipeux et de la moelle osseuse sont largement utilisées dans les essais thérapeutiques pour leurs qualités anti-inflammatoires. Mais de nouvelles recherches menées par Mayo Clinic montrent que les cellules du foie pourraient représenter une valeur plus importante.
Mayo Clinic的研究人员发现，活体捐献者的肾脏中有一些用显微镜才能观察到的细微结构特征，从这些结构特征中或许可以预测肾脏在接受者体内移植失败的风险。这一发现发表于在线版的Journal of the American Society of Nephrology《美国肾脏学会期刊》上。
Summaries of recent Fred Hutch research studies, plus information on a press event at the upcoming AAAS annual meeting in Seattle.
Forscher von Mayo Clinic haben entdeckt, dass subtile Strukturmerkmale in Nieren von lebenden Spendern, die nur mit einem Mikroskop gesehen werden können, auf das Risiko für eine Abstoßung beim Empfänger hindeuten können.
اكتشف الباحثون لدى Mayo Clinic أن سِمات بنيوية دقيقة لا يمكن رؤيتها إلا بالمِجهر في الكُلى المأخوذة من المتبرِّعين قد تُنبئ بخطورة فشل زراعة الكُلى للمُتلقِّين. وقد نُشِرت نتائج الدراسة على الإنترنت في مجلَّة الجمعية الأمريكية لطب الكُلى.
Des chercheurs de Mayo Clinic ont découvert que de subtiles caractéristiques que l’on peut observer uniquement au microscope au niveau de la structure des reins provenant de donneurs vivants, pourraient prédire le risque d'échec des greffes chez les receveurs.
Los investigadores de Mayo Clinic descubrieron que algunas características estructurales sutiles de los riñones de los donantes vivos, las cuales solo es posible ver en el microscopio, pueden predecir el riesgo del fracaso del trasplante en el receptor.
Pesquisadores da Mayo Clinic descobriram que características estruturais sutis nos rins de doadores vivos que só podem ser vistas com um microscópio podem ajudar a prever o risco de transplantes malsucedidos nos receptores. Os achados foram publicados virtualmente no Journal of the American Society of Nephrology (Revista da Sociedade Americana de Nefrologia).
• An analysis compared transplant recipients who received kidneys through national kidney paired donation and those who received kidneys from other living donors (such as relatives, friends or other paired exchange mechanisms). • Despite a higher number of risk factors for poor outcomes in the kidney paired donation group, recipients in the two groups had similar rates of organ failure and mortality over a median follow-up of 3.7 years.
Legendary heart-lung transplant surgeon, researcher, and professor Sir Magdi Habib Yacoub, MD, today was honored with the 2020 Earl Bakken Scientific Achievement Award from The Society of Thoracic Surgeons during the organization’s 56th Annual Meeting.
Mayo Clinic researchers have discovered that subtle structural features in kidneys from living donors that can only be seen with a microscope may predict the risk of transplant failure in recipients. The findings are published online in the Journal of the American Society of Nephrology.
• In analyses of biopsies of deceased donor kidneys, a repeat biopsy often showed very different findings than the initial biopsy, calling into question decisions to decline an organ based on the initial biopsy findings. • Although the first biopsy findings were not associated with post-transplant outcomes, findings from the second biopsies—which were performed in a relatively standardized manner at one organ procurement organization and read by the same group of pathologists—provided useful information about how well the organ functioned after transplantation.
• Subtle structural features of donated kidneys—which were observed through biopsies taken at the time of donation—were associated with the longevity of organs after they were transplanted.
The NYU Langone Transplant Institute performs innovative heart transplant surgery that will increase organ availability for heart transplants.
Las células mesenquimales del estroma procedentes del tejido graso y de la médula ósea se emplean ampliamente en ensayos terapéuticos por sus cualidades antiinflamatorias, pero un nuevo estudio de Mayo Clinic descubre que las células hepáticas podrían ser más valiosas.
Mesenchymal stromal cells from fat tissue and bone marrow are widely used in therapeutic trials for their anti-inflammatory qualities, but new Mayo Clinic research finds that liver cells may be of greater value. The study, published in Liver Transplantation, finds that liver mesenchymal stromal cells have immunoregulatory qualities that make them more effective than similar cells derived from adipose, or fat, tissue and bone marrow.
Vanderbilt University Medical Center tied for first place as the busiest heart transplant program by volume in the United States in 2019.
Hackensack Meridian Hackensack University Medical Center today announced that it became the first hospital in the New Jersey to perform a kidney transplant with a kidney preserved at its own Organ Preservation Center using the LifePort Kidney Transporter, an ex vivo hypothermic machine preservation technology. Hypothermic machine preservation is a cutting-edge, life-saving technology that increases a kidney’s viability and lifespan, improving patient outcomes.
A new study from Washington University School of Medicine in St. Louis suggests that extremely rare, harmful genetic mutations present in healthy donors’ stem cells — though not causing health problems in the donors — may be passed on to cancer patients receiving stem cell transplants, potentially creating health problems for the recipients. Among the concerns are heart damage, graft-versus-host disease and possible new leukemias.
Researchers from the University Hospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keeps them alive outside the body for one week.
A new Johns Hopkins Medicine-led study provides the strongest evidence to date that hundreds of deceased donor kidneys, discarded each year after being deemed not suitable under current medical criteria, can be transplanted safely and effectively.
• In a study of kidney transplant recipients, those with higher adherence to the Mediterranean diet were less likely to experience kidney function loss.
Four University of Chicago Medicine patients who received rare triple-organ transplants are encouraging people to register as organ and tissue donors, hoping to raise awareness about giving the gift of life during a holiday season focused on giving.
Erika Hosey, a cardiovascular technician at University Hospitals Ahuja Medical Center, ended the year by giving a life-changing gift to a patient in need. While performing a routine cardiac stress test, she drummed up a conversation. She learned that her patient, Denise Butvin, had kidney disease and needed transplant surgery. “Erika just blurted out…I’ll give you my kidney,” said Butvin. “I was in shock. I couldn’t believe this was real.” While Butvin is a positive person, she has been through an emotional rollercoaster of ups and downs and on waitlists in Ohio and Pennsylvania for five years. Her family and friends were not an organ match. Both her sister and father were on dialysis for many years and passed away from kidney disease, so she knew how pressing this transplant surgery was. Hosey started the process the next day, and after a few weeks of testing turned out to be a perfect donor match. “To be a kidney donor match for someone is really a shot in the dark,” she
While the donation and transfusion of blood are very common, and relatively simple as far as medical procedures go, the path from donor to recipient is more complex than most people may realize.
The US Department of Health and Human Services (HHS) today took bold steps in two proposed rules to increase the availability of organs for the 113,000 Americans waiting for a lifesaving organ transplant – 20 of whom die each day – and to strengthen support for Americans who choose to be living donors. Both proposed rules advance policy changes the American Society of Nephrology has long been advocating for and is strongly supportive of.
A new analysis shows that a donor stem cell transplant following treatment with an immune checkpoint inhibitor is generally safe and produces good outcomes for patients with Hodgkin lymphoma.
For patients with high-risk myeloid cancers undergoing a donor stem cell transplant, adding the targeted drug venetoclax to a reduced-intensity drug regimen prior to transplant is safe and does not impair the ability of the donor cells to take root in recipients’ bodies, a study led by Dana-Farber Cancer Institute researchers suggests.
Cleveland Clinic researchers have found that using lungs from donors who are considered high risk for certain infectious diseases compared to standard risk donors results in similar one-year survival for recipients. In addition, researchers saw no difference in rejection or graft (donor lung) survival after one year in patients receiving lungs from increased-risk donors. The study was published recently in the Journal of Thoracic and Cardiovascular Surgery.
Rutgers Cancer Institute of New Jersey investigators compared outcomes for allogeneic stem cell transplant patients when post-transplant cyclophosphamide (PCy) was added as part of standard treatment than if standard treatment was given alone. Results showed an increase in the number of patients who were free of disease and off immunosuppression at one-year in the PCy cohort.
HCVguidelines.org — a website developed by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America to provide up-to-date guidance on the management of hepatitis C — was recently revised to reflect important developments in the identification and management of chronic hepatitis C (HCV)
New research led by a team from the University of Chicago Medicine suggests treatment guidelines for newly diagnosed prostate cancer patients who are waiting for an organ transplant or who are post-transplant.
Dana-Farber Cancer Institute researchers will present more than 40 research studies at the 61st American Society of Hematology (ASH) Annual Meeting on December 7-10 in Orlando, Fla.
Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome (HLHS) and Children's of Alabama announce their collaboration within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.
The 61st American Society of Hematology Annual Meeting and Exposition will take place Dec. 7–10 in Orlando, Florida
A recent study published in Muscle & Nerve appears to show that needle electromyography can play a major role in reinnervation in face transplantation.
Juan Cueto did not feel sick, but he was losing weight rapidly and was devastated with the knowledge that he had two life threatening diseases, cancer and a liver disease.
Researchers report that among patients with obesity, robotic kidney transplants produce survival outcomes comparable to those seen among nonobese patients. The study includes data collected over 10 years from more than 230 robotic-assisted kidney transplants in patients with obesity.
Vanderbilt University Medical Center is launching a living liver donor transplant program, significantly increasing the number of available organs for life-saving transplants
University of Maryland School of Medicine researchers found that lung transplant recipients with early signs of organ rejection could increase their chance of survival and improve lung function by inhaling a liposomal form of the immunosuppression drug cyclosporine through an investigational nebulizer.
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