Iowa State's Edward Yu has spent years studying the structures bacteria use to resist antibiotics. He and his research group recently published two more papers describing the pumps and transporters that certain disease-causing bacteria use to keep antibiotics away.
At the 69th AACC Annual Scientific Meeting & Clinical Lab Expo—the premier global conference and exhibit for laboratory medicine—visionaries in the field will illuminate the pioneering research and technology paving the way for better clinical testing and patient care. From July 30–August 3 in San Diego, the meeting will feature more than 200 talks on a broad range of timely healthcare topics. Highlights of these include plenaries that explore transforming biology using CRISPR engineering and new applications for DNA sequencing; preserving fertility in young people with cancer; how clinical testing can help solve public health crises; and a session that uncovers the precision diagnostics that are creating a digital health revolution.
While discussions on stewardship are often focused on fighting infection among the sickest patients, those aren’t the only people taking these drugs. Data from the CDC shows the average dermatology provider wrote 669 antibiotic prescriptions in 2014, the most recent year for which data are available. That is, by far, the highest average of any provider specialty. For some perspective, the next closest group was primary care physicians, who wrote an average of 483 prescriptions per provider. It begs the question of whether dermatology should be under the microscope when it comes to stewardship.
Researchers from the Perelman School of Medicine at the University of Pennsylvania have found evidence that the most difficult C. difficile cases, known as multiple recurring C. difficile infections (mrCDI), are rapidly becoming more common.
Scientists from the University of Birmingham and Norwich Research Park have discovered a link between a major mechanism of antibiotic resistance and resistance to the disinfectant triclosan which is commonly found in domestic products.
Using nanotechnology, image processing tools and statistical analysis, Technion researchers have developed a system that enables faster diagnostics, earlier and more effective treatment of infectious bacteria, and improved patient recovery times.
University of Warwick expertise is contributing to a world-first £1.5million study aiming to tackle one of the biggest public health threats we face – antibiotic resistance.
Benjamin Koch and his co-authors treated bacteria the way they would any ecosystem, using genomic "tags" to track bacterial transmission.
Antibiotics were the wonder drug of the 20th century, but bacteria evolved resistance. According to the CDC, more than 2 million people in the U.S. develop MDR infections every year. Researchers at Univ. of Utah developed a rapid screen to pair existing FDA-approved drugs to combat MDR infections.
The use of topical antibiotics can dramatically alter communities of bacteria that live on the skin, while the use of antiseptics has a much smaller, less durable impact. The study, conducted in mice in the laboratory of Elizabeth Grice, PhD, an assistant professor of Dermatology in the Perelman School of Medicine at the University of Pennsylvania, is the first to show the long-term effects of antimicrobial drugs on the skin microbiome.
Most UTIs are caused by E. coli that live in the gut and spread to the urinary tract. A new study from Washington University School of Medicine in St. Louis has found that a molecular decoy can reduce the numbers of UTI-causing bacteria in the gut, potentially reducing the risk of recurrent UTI.
GW Researchers received a $3 million U01 grant from the National Institutes of Health to test the efficacy of a candidate recombinant hookworm vaccine, the next step in their goal to fight hookworm.
UMB grants licensing rights for new vaccine candidate to Serenta Biotechnology, LLC, whose co-founder, Mark Shirtliff, PhD, professor at the University of Maryland School of Dentistry and the UM School of Medicine.
Scientists at The Scripps Research Institute (TSRI) have given new superpowers to a lifesaving antibiotic called vancomycin, an advance that could eliminate the threat of antibiotic-resistant infections for years to come.
A team of researchers found that combinations of three antibiotics – that are each ineffective against superbugs when used alone – are capable of eradicating two of the six ESKAPE pathogens when delivered together.
Technion researchers say a combination of metals and organic acids is an effective way to eradicate cholera, salmonella, pseudomonas, and other pathogenic bacteria. The combination also works on bacteria that attack agricultural crops.
Directly observed therapy (DOT) for multidrug-resistant tuberculosis (MDR TB) was associated with a 77 percent decrease in mortality in the United States, compared to self-administered therapy from 1993 to 2013, according to new research presented at the ATS 2017 International Conference.
Research findings to be published about new blood test technology that will greatly reduce errors in labwork and improve care in public health and infectious disease. Press briefing scheduled for May 16, reserve press access to live virtual event now.
Leading hospital “superbugs,” known as the enterococci, arose from an ancestor that dates back 450 million years — about the time when animals were first crawling onto land (and well before the age of dinosaurs), according to a new study.
New research published May 4 in the New England Journal of Medicine demonstrated that a buprenorphine can safely cut the duration of therapy nearly in half for infants withdrawing from opioids.
The human body produces about a gallon of mucus per day. By studying and replicating mucus’ natural ability to control pathogenic bacteria, scientists hope to find new methods for combatting infections and antibiotic resistance.
Silver has been used to fight infections since ancient times. Today, researchers are using sophisticated techniques such as the gene-editing platform Crispr-Cas9 to take a closer look at how silver poisons pathogens. The work is yielding new insights on how to create effective antimicrobials and avoid the pitfalls of antimicrobial resistance.
Scientists and physicians at University of California San Diego School of Medicine, working with colleagues at the U.S. Navy Medical Research Center – Biological Defense Research Directorate (NMRC-BDRD), Texas A&M University, a San Diego-based biotech and elsewhere, have successfully used an experimental therapy involving bacteriophages — viruses that target and consume specific strains of bacteria — to treat a patient near death from a multidrug-resistant bacterium.
The University of Maryland School of Medicine has been awarded a $9 million seven-year grant to develop new tools against drug-resistant malaria in Southeast Asia and other regions where the disease is common.
A study from Indiana University published in the Proceedings of the National Academy of Sciences has found evidence that extremely small changes in how atoms move in bacterial proteins can play a big role in how these microorganisms function and evolve.
Bacteria are everywhere. And despite widespread belief, not all bacteria are “bad.” However, to combat those that can cause health issues for humans, there has been an over-reliance on the use of antibiotics – so much so, that many of them are now proving ineffective due to bacteria developing increased resistance to them. This paradigm led researchers at NSU to take another look at how bacteria do what they do to see if there was another way to approach this issue.
Antibiotics save lives every day, but there is a downside to their ubiquity. High doses can kill healthy cells along with infection-causing bacteria, while also spurring the creation of “superbugs” that no longer respond to known antibiotics. Now, researchers may have found a natural way to cut down on antibiotic use without sacrificing health: a maple syrup extract that dramatically increases the potency of these medicines.
Case Western Reserve University and Q2 Pharma Ltd., an Israeli biopharmaceutical company, have signed a two-year option to license small molecule, antivirulence technology to potentially treat bacterial infections such as methicillin-resistant staphylococcus aureus (MRSA), the first known scientific effort of its kind.
Nemus Bioscience and the University of Mississippi report significant anti-MRSA synergy data utilizing proprietary cannabinoid-based anti-infective platforms
The team analyzed soil samples from 11 dairy farms in the United States, and found that the amount of antibiotic resistant genes was 200 times greater in soil near manure piles compared with soil that wasn’t.
Researchers from Queen’s University Belfast have discovered why antibiotics for treating people with cystic fibrosis are becoming less effective and how fat soluble vitamins might offer a viable solution
Scientists from the Florida campus of The Scripps Research Institute (TSRI), the University of California (UC), San Diego and the University of Illinois have found that two immune system molecules may be key to the development of drug resistance in estrogen-driven breast cancers.
The deadly fungus, Candida auris, is resistant to entire classes of antimicrobial drugs, limiting treatment options for those infected. Now, in a first-of-its-kind study, microbiologists at Case Western Reserve University School of Medicine have provided previously uninvestigated details pertaining to C. auris drug resistance and growth patterns.
Researchers in Cleveland, Ohio have taken a significant step toward defeating antibiotic-resistant infections by combining two different antibiotics that each block a different kind of drug-destroying enzyme secreted by bacteria.
Mayo Clinic scientists have identified a specific protein implicated in drug resistance, as well as a possible therapeutic tool. Their work appears in the EMBO Journal.
Computer model shows what happens at the molecular level during severe allergic reactions to abacavir, a common HIV drug
The scientists discovered the antiprotozoal drug pentamidine disrupts the cell surface of Gram-negative bacteria, even the most resistant. The anti-fungal medication was particularly potent when used with antibiotics against multidrug resistant bacteria.
People seeking help for mental disorders are more likely to refuse or not complete the recommended treatment if it involves only psychotropic drugs, according to a review of research published by the American Psychological Association.
Case Western Reserve University School of Medicine and Louis Stokes Cleveland VA Medical Center are teaming up to take on the rising problem of antibiotic resistance.
In a new, first-of-its-kind study, researchers from Case Western Reserve University School of Medicine have found a 700-percent surge in infections caused by bacteria from the Enterobacteriaceae family resistant to multiple kinds of antibiotics among children in the US. These antibiotic resistant infections are in turn linked to longer hospital stays and potentially greater risk of death.
A study by researchers at the University of Southampton shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery. The systematic review of existing literature is published in Pediatrics.
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial scourge that is resistant to most common antibiotics and thus difficult to treat, particularly in children where it commonly causes complicated skin and skin structure infections. In a randomized, controlled clinical trial — the first of its kind — a multi-institution research team reports that daptomycin, part of a new class of antibiotics currently approved only for use in adults, is effective and well-tolerated in children.
Experimental evidence confirms what surveys have long suggested: Physicians are more likely to prescribe antibiotics when they believe there is a high expectation of it from their patients, even if they think the probability of bacterial infection is low and antibiotics would not be effective, according to a study published by the American Psychological Association.
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