UC San Diego scientists developed an artificial intelligence tool that could accelerate the development of new high affinity antibody drugs.
Inmazeb (REGN-EB3), developed by Regeneron, is a three-antibody cocktail designed to target the Ebola virus glycoprotein. The drug was first approved for clinical use in October 2020, but its exact mechanism of action has remained unclear.
Malgré les recommandations, le traitement de première intention de l'état de mal épileptique est souvent inapproprié. Des études suggèrent que jusqu'à deux tiers des patients reçoivent des doses subcliniques de benzodiazépines, soit avant d'arriver à l'hôpital, soit pendant un traitement hospitalier d'urgence. Existe-t-il des solutions ?
A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore has breathed new life into an existing drug — combatting a type of blood cancer called T-cell acute lymphoblastic leukaemia, or T-ALL. The drug, called PIK-75, was initially discovered over a decade ago but was dismissed in favour of newer ones. Now, it has made a comeback that deems it unmissable — the researchers established that the drug could block not just one but two crucial cancer-causing pathways of T-ALL, enabling them to develop new treatments that could effectively stem the disease.
Expanding anesthesiology residency programs — even in the absence of federal funding — may help medical institutions save staffing costs and address projected shortages of anesthesia care professionals, suggests a first-of-its-kind study being presented at the American Society of Anesthesiologists’ ADVANCE 2023, the Anesthesiology Business Event.
Inaccurately recording the start of anesthesia care during a procedure is common and results in significant lost billing time for anesthesia practices and medical centers, suggests a study being presented at the American Society of Anesthesiologists’ ADVANCE 2023, the Anesthesiology Business Event.
The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.
GRF's leadership awards will be presented at the Glaucoma 360 Annual Gala on February 2, 2023 at the iconic Westin St. Francis Hotel in San Francisco.
Santen will receive GRF’s highest honor, the Catalyst Award, at the Glaucoma 360 Annual Gala on February 2, 2023, in San Francisco.
Long-term treatment of healthy middle-aged mice with a cancer drug increases lifespan by 10% on average, equivalent to 3 years.
R. Scott Struthers, Ph.D., has been awarded the Endocrine Society’s John D. Baxter Prize for Entrepreneurship for his contributions to drug discovery and development programs for endocrine diseases, the Society announced today.
Female lymphoma patients undergoing the morning chemotherapy treatment show a lower survival probability than those undergoing the afternoon treatment.
Just as a choreographer’s notation tells a dancer to strike a particular pose, an enzyme newly discovered by Rice University scientists is able to tell specific molecules precisely how to arrange themselves, down to the angle of single hydrogen bonds.
Nucleic acid-targeting photodynamic therapy (PDT) is a promising type of targeted therapy that is being actively researched. This treatment relies on special photosensitizers, a type of drug that binds at specific locations in a cell’s DNA.
A combination of two next-generation immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer, a disease which has not previously responded well to immunotherapies, according to a Dana-Farber Cancer Institute researcher.
X-linked adrenoleukodystrophy (X-ALD) is the most common of a group of around 50 rare diseases of the white matter of the brain, the so-called leukodystrophies.
States that permit recreational use of cannabis see a reduction in demand for prescription codeine, an opioid with a high potential for misuse.
James Collins III, Ph.D., Associate Professor of Pharmacology at UT Southwestern Medical Center, will receive the 2023 Edith and Peter O’Donnell Award in Biological Sciences from The Academy of Medicine, Engineering and Science of Texas (TAMEST) for broadening understanding of schistosomiasis.
New UCLA-led research suggests that antiretroviral drugs called TAF and TDF directly reduce energy production by mitochondria, structures inside cells that generate the power that cells use to function. Both drugs led to reduced cellular oxygen consumption rates, a measure of the ability of the mitochondria to produce energy, compared with controls.
This basic scientific research provides a comprehensive structural framework that should help drug developers rationally design safer drugs to relieve severe pain.
Patients hospitalized with fractures typically receive an injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots.
Indiana University researchers have potentially discovered a new way to block the brain’s reward response to opioids, reducing their potential for addiction without reducing their therapeutic aspects.
If pharmaceutical companies shared their intellectual property rights to vaccines with the global community, millions of lives could be saved in future pandemics, according to a new paper co-authored by faculty at Binghamton University, State University of New York.
Research on fungi underway at the University of Kansas has helped transform tough-to-recycle plastic waste from the Pacific Ocean into key components for making pharmaceuticals.
A novel peptide designed by University of California, Irvine researchers has been found to suppress the damaging lung inflammation seen in acute respiratory distress syndrome, or ARDS. Their study, which appears in iScience, describes the first specific treatment designed to prevent the deadly disease, which can appear in patients with severe lung injury from infections with bacteria and viruses, like pneumonia, flu, respiratory syncytial virus (RSV) and COVID-19.
A first-of-its-kind study identifies mechanisms that explain how a drug commonly used to treat HIV and hepatitis causes kidney disease and kidney injury. The study is published ahead of print in Function.
It’s ‘lights out’ for antibiotic-resistant superbugs as next-generation light-activated nanotech proves it can eradicate some of the most notorious and potentially deadly bacteria in the world.
Although rare compared to adult liver cancers, hepatoblastoma is the most common pediatric liver malignancy, and its incidence is increasing.
The Society of Laboratory Automation and Screening (SLAS), announces the appointment of Lesley Mathews, Ph.D., as its new Scientific Director, effective January 16.
Brain structures which could predict an individual’s predisposition to accidental awareness under anaesthetic have been identified for the first time by neuroscientists in Trinity College Dublin.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a drug combination that may offer a better prognosis for children diagnosed with MYC amplified Medulloblastoma, an often deadly form of brain cancer.
RUDN University chemists, biologists and physicians have found a simple way to predict the properties of compounds of drugs with metals. This can be done using topological indices - numbers that describe the structure of the molecule. The results will help finding new metal complexes that will improve the activity of existing drugs.
The U.S. Food and Drug Administration (FDA) recently granted approval to Lecanemab, the first Alzheimer’s disease treatment to win approval since the largely failed rollout of Aduhelm two years ago.
Benjamin K. Mizell, MD, an anesthesiologist with a proven track record of leading major Mass Eye and Ear initiatives including its electronic medical record integration, has been named chief of Anesthesia at Mass Eye and Ear.
Promising results from an ongoing clinical trial a three-drug treatment may improve survival in patients with newly diagnosed multiple myeloma who have undergone preliminary treatment followed by a stem cell transplant.
A new program is finding many diagnosed in childhood with antibiotic allergies are no longer allergic after retesting
Morteza Mahmoudi, an assistant professor in MSU’s Department of Radiology, explains why addressing disagreements with stronger standards will help ensure future nanomedicines are safe, effective and successful.
Maureen Murphy, Ph.D., has been named Deputy Director of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute. Murphy will guide the growth of the Cancer Center through expanding research initiatives and collaboration, education and training programs, and recruitment to fast-track innovative basic cancer research discoveries into future transformative drugs and therapies.
People don’t always behave impeccably in relationship to others. When we notice that this has inadvertently caused harm, we often feel guilty. This is an uncomfortable feeling and motivates us to take remedial action, such as apologizing or owning up.
The Alzheimer’s Drug Discovery Foundation (ADDF) and Harrington Discovery Institute at University Hospitals in Cleveland have granted an ADDF-Harrington Scholar Award to Christiane Wrann, PhD, DVM, Associate Professor in Medicine at the Cardiovascular Research Center and the McCance Center for Brain Health at Massachusetts General Hospital and the Harvard Medical School in Boston. Dr. Wrann will receive funding and drug development guidance to help advance her research towards potential new therapies for patients suffering from Alzheimer’s disease.
GenVault, one of the nation’s most secure, comprehensive commercial facilities for bioinventory storage and transport, recently received three significant certifications, augmenting its already robust list of certifications, registrations, and compliance.
Among people with epilepsy, Black, Latino and Native Hawaiian and Other Pacific Islander people are less likely to be prescribed newer drugs than white people, which can be a marker of the quality of care, according to a study published in the January 11, 2023, online issue of Neurology® Clinical Practice, an official journal of the American Academy of Neurology.
RUDN University researchers combined the advantages of artificial and natural polymers when creating nonwoven materials for use in medicine.
RUDN University chemists have found a new method that makes it possible to obtain key fragments of alkaloids under mild conditions. These substances are in demand in the pharmaceutical industry. The new approach works on the principle of dominoes - reactions automatically occur one after another.
On any given Tuesday, you will find Brian C. Jensen, MD, cardiologist and physician-scientist, tending to patients in his cardio-oncology clinic. His schedule is packed to the brim with cancer patients. But not patients with heart cancer. The largest number of patients he sees are cancer patients who have developed, or are at risk of developing, heart damage in response to their chemotherapy regimens.
Stuart Therapeutics, Inc. announces that it has expanded its drug development pipeline, adding programs in diabetic macular edema and myopia.
Inexpensive iron salts are a key to simplifying the manufacture of essential precursors for drugs and other chemicals, according to scientists at Rice University.
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