Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease. Tests in human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name.
Drinking artificially-sweetened beverages is associated with a significantly lower risk of colon cancer recurrence and cancer death, a team of investigators led by a Yale Cancer Center scientist has found. The study was published today in the journal The Public Library of Science One.
Shape Memory Medical recently announced FDA clearance for U.S. marketing of their IMPEDE Embolization Plug, a technology funded by NIBIB and created to block irregular blood vessels.
A research team led by Duke Cancer Institute scientists has found that this blood cancer infiltrates the central nervous system not by breaching the blood-brain barrier, but by evading the barrier altogether.
By some estimates, 18 million people die each year from sepsis triggered by endotoxins – fragments of the outer membranes of bacteria. A biochemical engineer at Missouri University of Science and Technology has patented a method of removing these harmful elements from water and also from pharmaceutical formulations.Her goal: improve drug safety and increase access to clean drinking water in the developing world.
EKF Diagnostics, the global in vitro diagnostics company, announces U.S. Food and Drug Administration 510(k) clearance and CLIA waiver for the Company’s hand-held, reagent-free hemoglobin analyzer, the DiaSpect Tm. The device is cleared for use in point of care (POC) and Certificate of Waiver settings, such as physicians’ offices, clinics and other non-traditional laboratory locations.
Bloodstream infections can be life-threatening to individuals undergoing kidney dialysis. Following infection control procedures is critical, yet best practices may not always occur at busy dialysis facilities.
If a hepatitis C vaccine were successfully developed, it would dramatically reduce transmission of hepatitis C among drug users. even if the vaccine did not provide complete immunity, according to a study published in Science Translational Medicine.
Researchers discover new clues about a recently identified blood cell condition known as clonal hematopoiesis, implicated in hematologic cancers, cardiovascular illness Surprisingly, the study reveals that inherited genetic variants can drive the condition by fueling additional mutations later in life The findings can help inform ways to gauge disease risk based on specific mutations, develop strategies to avert disease Clonal hematopoiesis is estimated to affect more than 1 in 10 people older than 65
XaTek Inc., a Cleveland-based company developing a portable sensing system that can quickly assess the clotting ability of a person’s blood, recently raised $9.1 million in Series A capital to further advance and test the device, called ClotChip.
Two years after inventing a microfluidic chip believed to help detect a life-threatening blood infection, researchers in the Texas Tech University Department of Chemistry & Biochemistry and the Texas Tech University Health Sciences Center are finally seeing their product work successfully for human patients.
Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, the first demonstration of a clinically relevant reduction of gene expression in a large animal model using genome editing. This finding could lead to a possible new approach for treating heart disease patients who do not tolerate PCSK9 inhibitors—drugs that are commonly used to combat high cholesterol.
An international team of leukemia scientists has discovered how to predict healthy individuals at risk of developing acute myeloid leukemia (AML), an aggressive and often deadly blood cancer.
Research led by Washington University School of Medicine in St. Louis has shown, in mice, that genetic material can be delivered to damaged cells in the kidneys, a key step toward developing gene therapy to treat chronic kidney disease. The potentially fatal condition affects 30 million Americans, most of whom don’t realize they have chronic kidney disease.
Researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have found that the cost for the 10 “highest spend” medications in Medicare Part D — the U.S. federal government’s primary prescription drug benefit for older citizens — rose almost one-third between 2011 and 2015, even as the number of persons using these drugs dropped by the same amount.
A study in the American Journal of Critical Care finds that a scoring system based on the PIRO concept was useful in predicting mortality in surgical intensive care patients with severe sepsis or septic shock due to an intra-abdominal source.
Researchers develop a simple and efficient method to induce human pluripotent stem cells to become blood, which could be key in future treatments for blood disorders, immune deficiencies and cancer
Infection with the hepatitis C virus (HCV) is a contagious liver disease with symptoms that range from mild illness for a few weeks to serious, lifelong liver problems. Veterans with HCV infection are almost three times as likely to have an alcohol use disorder (AUD) than veterans without HCV. It is not well understood how the dual occurrence of HCV infection and an AUD impacts a person’s immune system, mood, and brain function. This study investigated how a co-existing AUD contributes to inflammation and psychiatric problems in adults with HCV.
Loyola Medicine neurologist José Biller, MD, is co-editor of an authoritative new textbook on uncommon causes of stroke. "Uncommon Causes of Stroke" is a comprehensive guide for healthcare professionals diagnosing, treating and assessing complex causes of strokes and other cerebrovascular disorders.
For women, even mild sleep problems can raise blood pressure, finds study.
Actinium-225 is a promising isotope for cancer treatment. Only a few places in the world can produce an extremely limited supply of it. Recently, researchers at the Department of Energy’s national laboratories have collaborated to use particle accelerators to expand this isotope’s availability.
National Comprehensive Cancer Network releases new patient guidelines for liver, gallbladder, and bile duct (hepatobiliary) cancers, sponsored by the Global Liver Institute.
BIDMC researchers led a retrospective analysis of four randomized clinical trials focused on the effects of DAA therapies in patients with HCV-associated liver failure and developed a new means of predicting improvement in liver function in response to DAA treatment.
A study led by The University of Texas MD Anderson Cancer Center revealed that the investigational drug quizartinib prolonged overall survival for patients with a deadly form of acute myeloid leukemia (AML) linked to a genetic mutation called FMS-like internal tandem duplications (FLT3-ITD).
Scientists have developed an algorithm that predicts potentially dangerous low blood pressure, or hypotension, that can occur during surgery. The algorithm identifies hypotension 15 minutes before it occurs in 84 percent of cases, the researchers report in a new study published in the Online First edition of Anesthesiology.
A drug discovered and advanced by The University of Texas MD Anderson Cancer Center’s Institute for Applied Cancer Science (IACS) and the Center for Co-Clinical Trials (CCCT) inhibits a vital metabolic process required for cancer cells’ growth and survival.
Researchers have demonstrated that a program aimed at helping people modify lifestyle factors such as diet and exercise is as effective as medication at reducing blood pressure.
By altering the genetic code in bacteria, researchers at The University of Texas at Austin have demonstrated a method to make therapeutic proteins more stable, an advance that would improve the drugs' effectiveness and convenience
The number of insurance denials for life-saving hepatitis C drugs among patients with both private and public insurers remains high across the United States. Private insurers had the highest denial rates, with 52.4 percent of patients denied coverage, while Medicaid denied 34.5 percent of patients and Medicare denied 14.7 percent.
By screening 250 user reviews and comments for a once popular -- but proven inaccurate -- mobile app claiming to change your iPhone into a blood pressure monitor, Johns Hopkins researchers have added to evidence that a high “star rating” doesn’t necessarily reflect medical accuracy or value.
Embolization -- the use of various techniques to cut off the blood vessels that feed tissue growth -- has gained traction over the past few decades to treat cancerous tumors, and one specific version is gas embolotherapy. During this process, the blood supply is cut off using acoustic droplet vaporization, which uses microscopic gas bubbles induced by exposure to ultrasonic waves. Researchers have discovered that these bubbles could also be used as potential drug delivery systems. The researchers report their findings this week in Applied Physics Letters.
Researchers share perspective about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials.
A new study finds stable patients on blood thinners may not need to get their blood drawn as often as they currently do. Researchers were able to increase the number of people waiting longer than five weeks in between their INR blood draws from less than half (41.8%) to more than two-thirds (69.3%).
Researchers have gained new insights into the virus that causes hepatitis B – a life-threatening and incurable infection. The discovery reveals previously unknown details about the shell of the vigenetic blueprint and could lead to new drugs to treat the infection.
Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease.
This month's tip sheet from Fred Hutch includes information about cancer care delivery and costs, partnering with Microsoft, understanding/changing cancer's genetics and a Mt. Everest climb for cancer research fundraising. To pursue any of these story ideas, please contact the individual listed for each.
The latest research and features in cell biology in the Cell Biology News Source
Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the “stemness” of chronic lymphocytic leukemia cancer (CLL) cells — their ability to self-renew and resist terminal differentiation and senescence.
Immunosuppressed patients with sepsis appear more likely to die if they are treated in a hospital caring for a relatively small number of these patients, according to new research published online in the Annals of the American Thoracic Society.
A new approach pioneered at the University of Pennsylvania’s Abramson Cancer Center may provide a new path towards treating Acute Myeloid Leukemia (AML) with CAR T cells.
UT Southwestern Medical Center geneticist Dr. Helen Hobbs is the 2018 recipient of the Institut de France Grand Prix Scientifique.
New Cleveland Clinic research shows for the first time that ibrutinib, an FDA-approved drug for lymphoma and leukemia, may also help treat the most common – and deadliest – type of brain tumor. The findings, published in Science Translational Medicine, offer hope that the drug may one day be used in patients with glioblastoma and improve poor survival rates.
Researchers at the University of Pennsylvania’s Abramson Cancer Center say a patient treated for chronic lymphocytic leukemia (CLL) in 2013 went into remission because of a single CAR T cell and the cells it produced as it multiplied, and has stayed cancer free in the five years since, with CAR T cells still present in his immune system.
Saint Louis University researcher Gina Yosten, Ph.D is pursuing solutions for people with diabetes who are at risk of life-threatening drops in blood sugar.
Hematopoietic Stem Cells (HSCs) give rise to blood and immune cells of the body, and are therefore essential for our survival. They are in a dormant state, but whenever new blood needs to be formed, such as after blood loss or chemotherapy, they are rapidly activated to compensate for the loss. After completing their mission, they need to go back to their dormant state. The group of Manuela Baccarini at the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, has now shown how intracellular signalling can safeguard this delicate balance between activation and dormancy. Their results are published in the prominent journal Cell Stem Cell.
National guidelines assume that all patients who’re diagnosed with clinical sepsis in an emergency department will be admitted to the hospital for additional care, but new research has found that many more patients are being treated and released from the ED for outpatient follow-up than previously recognized.
With the recently announced FDA approval of Kymriah to treat adults with lymphoma, the University of Michigan Rogel Cancer Center is the first center in Michigan to offer all currently available CAR T-cell therapies.
James Isbon was the second patient in the United States and the seventh in the world to have an aneurysm, or bulge, in the aortic arch above his heart repaired in a novel and minimally invasive way.
Considering the size of red blood cells, a new model for blood flow sheds light on why blood sometimes prefers some vessels over others.
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