Researchers have discovered a molecular mechanism that reprograms tumor cells in patients with advanced prostate cancer, reducing their response to anti-androgen therapy. The findings, based on a study in mice, could help to determine which patients should avoid anti-androgen therapy and identify new treatments for people with advanced prostate cancer.
To help women get an optimal ultrasound of the baby’s heart, one likely to be able to detect a heart defect, if present, a UCLA expert recommends they seek a provider that offers advanced technology and a thorough screening of the heart. Here are some questions patients should ask.
Although the odds of developing breast cancer are nearly identical for black and white women, black women are 42 percent more likely to die from the disease. A large, multi-institutional study, published on-line May 4, 2017, in JAMA Oncology, explores the germline genetic variations and tumor biological differences between black and white women with breast cancer.
A new $21 million gift to the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania from alumni Mindy and Jon Gray will cement and propel Penn’s preeminence as a leader in research to improve treatment and prevention strategies for hereditary cancers. The gift brings the Gray’s total commitment to $55 million, following their initial $25 million gift that established the Basser Center in 2012, and subsequent gifts to support the Center, which advances BRCA gene mutation-related science around the world.
As the nation struggles with soaring health care costs, a new report by RTI International shows that younger women diagnosed with breast cancer face a significant treatment burden.
Mothers smoking crack cocaine during pregnancy—and its lingering effects on their children—are the focus of 20-plus years of ongoing research by Case Western Reserve University
A new University of Washington study finds that smartphone apps to track menstrual cycles often disappoint users with a lack of accuracy, assumptions about sexual identity or partners, and an emphasis on pink and flowery form over function and customization.
A shorter course of radiation therapy given to breast cancer patients following mastectomy is safe and effective and cuts treatment time in half. That is according to data from a phase II clinical trial conducted by Rutgers Cancer Institute of New Jersey investigators and other colleagues who examined a hypofractionated regimen given over three weeks versus the traditional six week course of treatment.
UCLA study identifies a potential test that may help select patients for whom combination therapy could be most effective
Breast cancers detected by mammography screening do not spontaneously disappear or regress if left untreated, according to a new study published in the Journal of the American College of Radiology (JACR®). The scientific findings contradict claims that many cancers found via mammography may simply “go away” if left undiscovered or untreated.
New guidelines recommend that men aged 55 to 69 with no signs of prostate cancer have a conversation with their doctor about the benefits and drawbacks of screening for the disease.
Patients who expressed the tumor antigen NY-ESO-1 had more aggressive cancers and were more likely to die early from their disease, according to a large study conducted by Roswell Park Cancer Institute researchers and published online ahead of print in the journal Gynecologic Oncology.
Prostate cancer patients are willing to pay up to $2,000 of their own money for a new high-tech biopsy technique that significantly improves accuracy, according to a study published in the journal Urology Practice
New dye could help better identify ureter, the passage between kidney and bladder, and prevent injury during minimally invasive pelvic surgery for women.
More than 1 million married women ages 15-44 across the United States are infertile. Janet McLaren Bouknight, M.D., offers insight on the symptoms, diagnosis and treatment of infertile couples trying to conceive.
A financially strapped pregnant woman’s worries about the arrival and care of her little one could contribute to birth of a smaller, medically vulnerable infant, a new study suggests.
Women at the highest genetic risk for fracture benefit the most from hormone therapy, according to a first-of-its-kind study led by researchers at the University at Buffalo.
In a new study presented today at the APS annual meeting at Experimental Biology 2017, researchers have found that the immune system’s natural killer (NK) cells activate and change in response to placental ischemia. Disrupting these altered cells seems to blunt some of the dangerous complications of the condition, including high blood pressure (hypertension) and inflammation in the mother and growth restriction in the fetus.
Featured research includes a non-invasive new screening approach for breast cancer, leads for drug discovery and insights on a cancer-protective diet.
Lisa A. Newman, M.D., MPH, director of the Breast Cancer Center at the Henry Ford Cancer Institute, has been appointed by Susan G. Komen – the world’s largest nonprofit funder of breast cancer research – to its Scientific Advisory Board.
It has been shown that both heavy and occasional drinking among the general population are linked to eating less fruits and vegetables, and eating more processed and fried meat. This is particularly worrisome for pregnant women, as both drinking and inadequate nutrition can have adverse consequences for the fetus. This study investigated links between maternal diet and drinking during pregnancy.
After studying viruses for 15 years, Dr. Anthony van den Pol believes he has found one that can safely and effectively kill chemotherapy-resistant ovarian cancer.
Select breast cancer patients who achieved pathologic complete response (pCR) after chemotherapy may be able to avoid follow-up breast and lymph node, or axillary, surgery, according to new findings from researchers at The University of Texas MD Anderson Cancer Center. The study, published today in JAMA Surgery, identifies the exceptional responders who are at lowest risk for local metastases and thereby are candidates for less invasive treatment options.
A new study, supported by the Minamata Convention’s Interim Secretariat hosted by UN Environment, reveals that women of childbearing age living in four Pacific Island countries have elevated levels of mercury in their bodies.
Medication for addiction treatment (MAT) with buprenorphine or methadone is an appropriate and accepted treatment for pregnant women with opioid use disorder (OUD), according to a research review and update in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM). The journal is published by Wolters Kluwer.
An international team of collaborators retroactively examined the associations between survival among patients diagnosed with invasive epithelial ovarian cancer and those patients’ history of hypertension, heart disease, diabetes, and medications taken for those conditions. They found that while hypertension was linked to better outcomes, diabetes was associated with decreased survival.
University of Colorado Cancer Center Study uncovers discrepant decision-making for use of 21-gene assay in women with cancer: • Testing occurs in high-risk population, despite current evidence • Non-concordance with NCCN Guidelines® recommendations • Racial and socio-economic disparities found in testing use
NYU Lutheran is expanding maternity services to serve a growing Brooklyn. Ming C. Tsai, MD, will lead the way as the newly appointed chief of OB/GYN.
Men who attended a structured yoga class twice a week during prostate cancer radiation treatment reported less fatigue and better sexual and urinary function than those who didn’t, according to a clinical trial led by the Perelman School of Medicine at the University of Pennsylvania. It is the first randomized trial to look at the effect of twice-weekly yoga on the side-effects and quality of life issues caused by prostate cancer treatment.
In 2016, more than 181,000 new cases of prostate cancer were reported in the U.S., according to the American Cancer Society. The prostate-specific antigen (PSA) test is one of the earliest ways clinicians can detect prostate cancers in their patients. Sometimes, a high PSA level may be a sign of benign conditions such as inflammation; therefore, more reliable tests are under investigation to help urologists diagnose and treat the disease in an aging population. Now, researchers at the University of Missouri have explored how a specific protein’s status may allow clinicians to better identify prostate cancer progression while helping them to make rational decisions in treating the disease.
A new study from the University of Michigan Comprehensive Cancer Center examines the complex interaction between patients’ desires for contralateral prophylactic mastectomy and surgeons’ responsibility to minimize harm.
A UAB OB/GYN discusses when and why an adolescent female should see a gynecologist.
In adolescent girls with polycystic ovary syndrome (PCOS), bringing the amount of abdominal visceral fat and liver fat down to normal restores ovulation, normalizes the symptoms of androgen excess, and may help prevent future subfertility, new research from Spain suggests. The results of the study will be presented Tuesday, April 4, at ENDO 2017, the annual meeting of the Endocrine Society, in Orlando.
New Dana-Farber study shows patients with platinum resistant ovarian cancer who wouldn’t be expected to respond to a PARP inhibitor had partial shrinkage of their tumor with the addition of a kinase inhibitor.
Age-related female infertility explained by a defect in the choreography of chromosome sharing during cell division in eggs before they are fertilized.
A natural, or bioidentical, combined estradiol-progesterone capsule (TX-001HR) significantly decreases the frequency and severity of moderate to severe hot flashes in postmenopausal women, the Replenish study finds. Results of this phase 3, randomized, placebo-controlled, multicenter trial will be presented Monday at ENDO 2017, the Endocrine Society’s 99th annual meeting in Orlando, Fla.
Researchers have identified an apparent cause of inguinal hernia, or groin hernia, in older men: altered sex hormone levels that weaken and scar muscle tissue in the lower abdomen. Results of their study using an animal model will be presented Monday at ENDO 2017, the Endocrine Society’s 99th annual meeting in Orlando, Fla.
The natural fetal estrogen estetrol, also called E4, is being tested as a new drug that may help treat advanced prostate cancer, according to an ongoing industry-sponsored study from the Netherlands. The final results will be presented in a poster on Saturday, April 1, at ENDO 2017, the annual scientific meeting of the Endocrine Society, in Orlando, Fla.
Novel molecules called selective androgen receptor degraders (SARDs) may offer the next generation of treatment options for advanced prostate cancer, a new industry-sponsored study reports. The results of this research will be presented Saturday, April 1, at ENDO 2017, the 99th annual meeting of the Endocrine Society, in Orlando, Fla.
Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, shows the potential for increasing the aggressiveness of breast cancer through its behavior as an endocrine-disrupting chemical, a new study finds. The results, which tested BPS in human breast cancer cells, will be presented Saturday at ENDO 2017, the Endocrine Society’s 99th annual meeting in Orlando, Fla.
In an abstract that will be presented at a poster session to be held from 1 to 5 p.m. April 3 at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger Comprehensive Cancer Center researchers will report their preliminary findings that breast cancer cancer cells grew larger when they were transplanted into fatty, obese tissue.
Vaginal bacteria can trigger recurrent UTIs, according to a study in mice. The findings help explain why sex is associated with UTIs. When it gets in the bladder, the vaginal bacterium Gardnerella vaginalis triggers dormant E. coli from a prior infection to re-start multiplying, causing another UTI.
Three major national databases include varying estimates of racial gaps in the use of immediate breast reconstruction (IBR) after mastectomy for breast cancer, reports a study in the March issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Findings suggest that older women may be at higher risk for death because of their periodontal condition and may benefit from more intensive oral screening measures.
First-of-its kind study finds number of traumatic experiences and when they first occur significantly affects the risk of depression during menopause
Using a newly developed method researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) have been able to shed light on the complexity of genome reorganization occurring during the first hours after fertilization in the single-cell mammalian embryo. Their findings have recently been published in the journal Nature. The team of researchers (from three continents) have discovered that the egg and sperm genomes that co-exist in the single-cell embryo or zygote have a unique structure compared to other interphase cells. Understanding this specialized chromatin “ground state” has the potential to provide insights into the yet mysterious process of epigenetic reprogramming to totipotency, the ability to give rise to all cell types.
Northwestern Medicine has developed a miniature female reproductive tract that fits in the palm of your hand and could eventually change the future of research and treatment of diseases in women’s reproductive organs.This new 3-D technology — called EVATAR — is made with human tissue and will enable scientists to conduct much-needed testing of new drugs for safety and effectiveness on the female reproductive system.
The chemical bisphenol A, or BPA, appears to aid the survival of inflammatory breast cancer cells, revealing a potential mechanism for how the disease grows, according to a study led by researchers in the Department of Surgery at Duke University School of Medicine and the Duke Cancer Institute.
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