Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets

A small-molecule cocktail reprograms human cord blood erythroblasts into induced megakaryocytes with ex vivo functionality. The four small molecules extensively remodel the chromatin and induce the dynamic network transition from erythroid master genes to FLI1 and other megakaryopoiesis-related genes via a bi-potent precursor state.