Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m³C modification

Newswise — Zhang et al. identified an epitranscriptomic mechanism regulating cortical neural stem cells in the embryonic mouse brain and human forebrain organoids. Specifically, Mettl8 installs m3C modification on mitochondrial tRNAThr/Ser(UNC), which regulates mitochondrial protein translation and function, and loss of Mettl8 leads to accelerated embryonic cortical neural stem cell depletion.