The scientific program committee selected the five winning abstracts, out of more than 350 received, for their quality, originality and ingenuity.
“We felt it was important to acknowledge the full range of basic and clinical science in this honor,” said scientific program chair and INS President-Elect Timothy Deer, MD. “Our field is evolving so rapidly that not only is it helping patients who are living with chronic disease today, but also shedding light on underlying mechanisms. Together, this growing understanding can spur advances in emerging bioelectronic medicine and current neuromodulation therapies.”
The top five abstracts represent a range of conditions addressed by neuromodulation; neural prosthesis and restoration for central nervous system injury, symptom management for incurable and progressive neurological disorder, and drug-free analgesia for neuropathic pain.
The five winning submissions are:
Neural bypass – A collaboration by Chad Bouton and team members at Battelle in Columbus, Ohio with physicians at The Ohio State University Wexner Medical Center. A tetraplegic patient demonstrated the ability to use a neuroprosthetic brain implant system to intentionally move his hand and wrist. The implant, a 96-electrode array, was surgically placed on his motor cortex by OSU’s Ali Rezai, MD. A Battelle-built multichannel stimulator relayed signals to nerves in his arm governing muscle control. Neural activity detected by the cortical array was processed by Battelle’s algorithms and encoded patterns sent to the stimulator to activate muscles. The demonstration showed the system could bypass the injury in the spinal cord and link brain activity in his motor cortex to voluntary muscle activity in his arm, hand and wrist, so that he was able to make voluntary motions in real time with high accuracy. The patient has spent seven months with the research team, who collected 300 hours of data in developing their custom algorithm. The study protocol has been approved for up to five participants. (The abstract title is: “Implanted Motor Neuroprosthetic for Real-Time Cortical Control of Hand Movements in a Human with Tetraplegia”.)
‘Biometric’ Movement Disorder Index – Stephanie Tran, a neuroscience undergraduate who participated in a project at the Movement Disorders Centre of Western University in London, Ontario, presented findings of a research team that quantified the effects of deep brain stimulation in Parkinson’s disease patients. The team used a motion-capture suit to assess the slow, stiff movements of bradykinesia, which is commonly experienced by all Parkinson’s disease patients. Seven Parkinson’s disease patients were assessed while performing a simple clinical test of their voluntary movement. For comparison, seven healthy control subjects were recorded performing the same exercise. Each patient was assessed at three pre-defined device settings used in common practice. The team defined a “B-Index” for bradykinesia based on range of motion, angular velocity, and variability in time and amplitude. The group found that at six months post-implant, patients’ bradykinesia was reduced to the point that their B-Index was not statistically different from healthy controls under a stimulation setting that involved decreasing pulse width while using medium frequency and voltage. (The abstract title is: “Effects of Different Electrical Parameter Settings on Bradykinesia in Patients with Parkinson's Disease Treated with Subthalamic Deep Brain Stimulation”.)
Stroke Damage Repair – A preclinical investigation lead by Andre Machado, MD, PhD, at the Cleveland Clinic, that suggests deep brain stimulation (DBS) may aid the brain’s plasticity and ability to form new neural connections during recovery from stroke. The team’s research in rats showed that DBS promoted growth of neurons that specialize in release of the neurotransmitter glutamate, which aids learning and memory. The group had previously shown that DBS enhanced motor recovery after stroke. This abstract built on that earlier work by showing the effect was linked to enhanced formation of new neural connections in the damaged area. They believe this is the first time that a deep brain stimulation therapy has shown the potential for selective nerve growth after focal injury, implying there may be a neurorestorative potential. As with any new finding, the research remains preliminary and the team would need to replicate these findings before expanding further on the research. (The abstract title is: “DBS of the cerebello-thalamo-cortical pathway selectively modulates glutamatergic and gabaergic neurogenesis in the perilesional cortex after stroke”.)
Picturing Pain Therapy Impact on the Brain – Imaging studies by Quinn Hogan, MD, of the Department of Anesthesiology at the Medical College of Wisconsin and colleagues. The research team used functional magnetic resonance imaging (fMRI) to show that parts of the brain’s so-called “pain network” are less activated when rats receive pain-relieving stimulation of the dorsal root ganglion (DRG), a structure at the edge of the spine. The researchers said the fMRI findings validate DRG stimulation as analgesic in rats, providing a model for future mechanistic research. (The abstract title is: “Functional MRI reveals analgesia by DRG stimulation in rats”.)
Preferred Stimulation Modes Compared – Nadia Kriek, MD and colleagues at the Center for Pain Medicine at the Erasmus University Medical Center in Rotterdam planned to present a comparison of five different spinal cord stimulation (SCS) modes, with the final data collected just prior to the meeting. They studied 43 patients who have a rare chronic pain condition, complex regional pain syndrome (CRPS), which is a leading indication for SCS since the therapy is highly effective in most CRPS patients. However, in some CRPS patients the therapeutic effect of SCS can diminish over time that results in the loss of pain control, as past studies have shown. Some of these patients that have lost the therapeutic benefit of SCS can regain pain control if the stimulation frequency is increased to more than 250 Hz. There is growing interest in new stimulation modes of SCS such as burst and high frequency. These new modes of stimulation along with conventional and sham stimulation were compared during the clinical trial. The patients began with conventional SCS of 40 Hz, and after three months, were crossed over randomly into treatment groups. Each patient randomly received 40 Hz, 500 Hz, 1200 Hz, burst and sham stimulation, with two-day “washout” intervals between each stimulation mode. After 10 weeks each patient decided which mode was preferred, and continued on that mode for another three months, with an assessment taken again at the end of that period. (The abstract title is: “High frequency, burst and conventional tonic spinal cord stimulation in patients with complex regional pain syndrome: preliminary results of a randomized and placebo controlled trial”.)
“This final abstract was selected on the basis of its sound clinical trial design and solid patient enrollment,” commented INS President Simon Thomson, MBBS, FRCA, FIPP. “Developing an evidence base and disseminating knowledge about best practices are among key objectives that our society advocates. With the advent of several new modes of stimulation for practitioners to choose between, these recent findings were expected to be of particular interest.”
All abstracts submissions accepted for presentation at the congress will be published online in the INS journal Neuromodulation: Technology at the Neural Interface.
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A high-resolution photo of International Neuromodulation Society Director-at-Large Ali Rezai, MD, performing neural bypass surgery at The Ohio State University Wexner Medical Center is available for download.
About the International Neuromodulation SocietyThe International Neuromodulation Society (INS) is a nonprofit medical society that unites clinicians, scientists and engineers to share scientific knowledge about all aspects of neuromodulation in order to encourage best medical practice. Founded in 1989 and based in San Francisco, CA, the INS presents up-to-date information about the full breadth of neuromodulation therapies through an interactive website at http://www.neuromodulation.com, chapter scientific meetings, the MEDLINE-indexed journal Neuromodulation: Technology at the Neural Interface, and its biennial world congress.
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