Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Newswise — Herdy et al. identify an enriched population of senescent neurons in the Alzheimer’s brain, which can be modeled in vitro using induced neurons (iNs) and eliminated with senotherapeutics. Alzheimer’s iNs present molecular and genetic markers of senescence and an inflammatory secretome that can trigger reactive astrogliosis.