Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos

Xu et al. profiled the genome-wide H3K9me3 distribution in human oocytes and early embryos. They found the function and mechanism of H3K9me3 modification on long terminal repeat (LTR) regulation and provide a detailed map of the sequential reprogramming of histone modifications in human pre-implantation embryo development.