'Provocative' New Evidence Links Vitamin D and Other Nutrients to Heart Disease

Newswise — Emerging research suggests that nutritional factors—including vitamin D, magnesium, and others—may influence the risk and progression of cardiovascular disease. The new data on nutrition and heart disease were the topic of a recent symposium and are summarized in the July issue of The American Journal of the Medical Sciences (AJMS), official journal of the Southern Society for Clinical Investigation (SSCI). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and biomedical intelligence for students, professionals, and institutions in medicine, nursing, allied health, pharmacy and the pharmaceutical industry.

"The prospect that macro- and micronutrients may play an important role in the appearance of diseases of the cardiovasculature and their progressive nature is both intriguing and provocative," according to the article's preface by Dr. Karl T. Weber. The article highlights key findings presented at the SSCI's Annual Scientific Session in New Orleans earlier this year. The symposium was presented in conjunction with the SSCI's Cardiovascular Club and the International Academy of Cardiovascular Sciences/North America.

New Evidence Links Vitamin D to Cardiovascular Disease

Several recent studies have identified low vitamin D levels as a common problem with many adverse health effects, including increased rates of cardiovascular disease. People with vitamin D deficiency are at increased risk of high blood pressure, heart failure, and ischemic heart disease, according to Suzanne Judd, MPH, PhD, of University of Alabama at Birmingham and Dr. Vin Tangpricha of Emory University. In patients who already have heart disease, low vitamin D may increase the risk of high blood pressure or sudden death.

Vitamin D deficiency may also help to explain the apparent relationship between osteoporosis-related fractures and heart failure, according to Dr. Syed H. Raza and colleagues. Osteoporosis and heart failure are both common conditions in older adults and share several risk factors—including low vitamin D. Pending further research to clarify this relationship, patients with heart failure need attention to their risks of osteoporosis and fractures.

So far, however, there is very little information on whether taking vitamin D supplements can avoid or reduce these risks. Rebecca B. Costello, PhD, of the National Institutes of Health's Office of Dietary Supplements outlines federal research initiatives to understand the effects of vitamin D on health. She urges rigorous scientific studies to clarify the relationship between vitamin D and cardiovascular disease, as well as other chronic diseases.

Other Nutrients May Also Affect Cardiovascular Risk

Could folic acid help prevent heart disease? Folic acid (vitamin B9) reduces levels of the amino acid homocysteine, which affects cardiovascular risk, according to Dr. Lydia A. Bazzano of Tulane University. However, studies have found that taking folic acid to reduce homocysteine does not lower cardiovascular risk in adults. Taking folic acid during pregnancy does appear to reduce the risk of congenital heart defects, however.

Low levels of nutrient— magnesium—may lead to a "cascade" of harmful inflammation-promoting events, according to Dr. Jay H. Kramer of George Washington University and colleagues. This may lead to disease of the heart muscle (cardiomyopathy), increasing vulnerability to injury from other forms of stress. Especially with the high rate of magnesium deficiency in the population, antioxidants and other medications—in addition to magnesium supplements—might help in reducing cardiovascular disease.

Patients with heart failure—especially African Americans—are prone to an imbalance of several nutrients, according to a presentation by Dr. German Kamalov and colleagues. The imbalance is accompanied by activation of certain hormones, leading to inflammation and wasting of soft tissues and bone. The authors discuss approaches to recognizing this nutritional imbalance, and suggest that a "polynutrient supplement" including calcium, magnesium, zinc, selenium, and vitamins D, B12, and B1 might play a role in heart failure management.

Despite the tantalizing new evidence, "The role of nutrition in the causation, prevention, and treatment of cardiovascular diseases is largely unexplored," Dr. Weber concludes. "Investigator-initiated, hypothesis-driven research conducted in a mode of discovery by a multidisciplinary team of basic and clinical scientists will undoubtedly open new frontiers and pave the way by identifying simple remedies that could advance the practice of medicine."

About The American Journal of the Medical Sciences

Founded in 1820, The American Journal of the Medical Sciences (AJMS) is the official journal of the Southern Society for Clinical Investigation. Regular features include Clinical and Basic Investigation studies, Reviews, Historical Articles, Case Reports, Images in the Medical Sciences. Other special features include contributions from the Southwestern Internal Medicine Conference, Cardiology Grand Rounds from the University of North Carolina and Emory University, Case Records of the VA Maryland Healthcare System/University of Maryland Medicine, and Clinical Pathological Correlation from Texas A&M Health Science/Scott & White Memorial Hospital, Images in the Medical Sciences. The AJMS publishes original articles dealing with topics such as infectious disease, rheumatology/immunology, hematology/oncology, cardiology, pulmonology/critical care, gastroenterology, nephrology, neurology and endocrinology. Visit the journal website at www.amjmedsci.com.

About the Southern Society for Clinical Investigation

Founded in 1946, the Southern Society for Clinical Investigation (SSCI) is a regional academic society dedicated to the advancement of medically-related research. Its major focus is on encouraging students and postgraduate trainees (residents and fellows) to enter academic medicine and to support junior faculty success in clinical investigation. SSCI members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. Visit the SSCI website at www.ssciweb.org.

About Lippincott Williams & Wilkins

Lippincott Williams & Wilkins (LWW) is a leading international publisher for healthcare professionals and students with nearly 300 periodicals and 1,500 books in more than 100 disciplines publishing under the LWW brand, as well as content-based sites and online corporate and customer services. LWW is part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals and institutions in medicine, nursing, allied health, pharmacy and the pharmaceutical industry.

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